Page last updated: 2024-12-11
monocillin i
Description
Research Excerpts
Clinical Trials
Roles
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Pathways
Study Profile
Bioassays
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Research Growth
Market Indicators
Description
monocillin I: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 6440561 |
CHEMBL ID | 215853 |
MeSH ID | M0411616 |
Synonyms (5)
Synonym |
---|
CHEMBL215853 |
monocillin i |
MLS004257395 |
smr003082525 |
6h-oxireno(e)(2)benzoxacyclotetradecin-6,12(7h)-dione,1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-, (1ar,2z,4e,14r,15ar)- |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (23)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID379398 | Displacement of geldanamycin from Hsp90 in human MCF7 cells lysate by SDS-PAGE | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID312050 | Induction of heat shock in mouse 3T3-Y9/B12 reporter cells at 5 uM by heat shock induction assay | 2007 | Journal of natural products, Dec, Volume: 70, Issue:12 | Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii. |
AID379404 | Inhibition of Hsp90 in human MCF7 cells assessed as upregulation of Hsp72 expression at 1 uM by chemiluminescence assay | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID379400 | Inhibition of Hsp90 in human MCF7 cells assessed as depletion of cellular level of IGF1R at 1 uM by chemiluminescence assay | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID379399 | Inhibition of Hsp90 in human MCF7 cells assessed as depletion of cellular level of IGF1R at 0.1 uM by chemiluminescence assay | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID312048 | Antiproliferative activity against human MCF7 cells by MTT assay | 2007 | Journal of natural products, Dec, Volume: 70, Issue:12 | Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii. |
AID379405 | Antiproliferative activity against human MCF7 cells by MTT assay | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID379397 | Inhibition of Hsp90 in rabbit reticulocyte lysate assessed as inhibition of heat-denatured firefly luciferase renaturation relative to geldanamycin | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID312047 | Antiproliferative activity against human NCI-H460 cells by MTT assay | 2007 | Journal of natural products, Dec, Volume: 70, Issue:12 | Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii. |
AID379395 | Cytotoxicity against in mouse 3T3-Y9/B12 cells at 10 uM | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID379403 | Inhibition of Hsp90 in human MCF7 cells assessed as upregulation of Hsp72 expression at 0.1 uM by chemiluminescence assay | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID427105 | Cytotoxicity against human dermal papilla cells by Alamar blue assay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity. |
AID1378625 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8 | Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
AID1378626 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8 | Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
AID379401 | Inhibition of Hsp90 in human MCF7 cells assessed as depletion of cellular level of ER at 0.1 uM by chemiluminescence assay | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID379394 | Induction of heat shock response in mouse 3T3-Y9/B12 cells at 5 uM by fluorescence technique relative to geldanamycin | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID312049 | Antiproliferative activity against human SF268 cells by MTT assay | 2007 | Journal of natural products, Dec, Volume: 70, Issue:12 | Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii. |
AID379402 | Inhibition of Hsp90 in human MCF7 cells assessed as depletion of cellular level of ER at 1 uM by chemiluminescence assay | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID1378628 | Antifungal activity against Peronophythora litchii after 8 hrs by conidial germination assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8 | Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
AID379396 | Inhibition of Hsp90 in rabbit reticulocyte lysate assessed as inhibition of heat-denatured firefly luciferase renaturation at 10 uM relative to geldanamycin | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. |
AID427104 | Inhibition of WNT5A mRNA expression in human dermal papilla cells after 24 hrs by quantigene assay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity. |
AID1378629 | Antifungal activity against Fusarium verticillioides after 8 hrs by conidial germination assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8 | Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
AID1378627 | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8 | Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (10)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 8 (80.00) | 29.6817 |
2010's | 2 (20.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 11.85
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.85) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 10 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |