Compounds > monocillin i
Page last updated: 2024-12-11

monocillin i

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Description

monocillin I: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6440561
CHEMBL ID215853
MeSH IDM0411616

Synonyms (5)

Synonym
CHEMBL215853
monocillin i
MLS004257395
smr003082525
6h-oxireno(e)(2)benzoxacyclotetradecin-6,12(7h)-dione,1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-, (1ar,2z,4e,14r,15ar)-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID379398Displacement of geldanamycin from Hsp90 in human MCF7 cells lysate by SDS-PAGE2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID312050Induction of heat shock in mouse 3T3-Y9/B12 reporter cells at 5 uM by heat shock induction assay2007Journal of natural products, Dec, Volume: 70, Issue:12
Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.
AID379404Inhibition of Hsp90 in human MCF7 cells assessed as upregulation of Hsp72 expression at 1 uM by chemiluminescence assay2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID379400Inhibition of Hsp90 in human MCF7 cells assessed as depletion of cellular level of IGF1R at 1 uM by chemiluminescence assay2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID379399Inhibition of Hsp90 in human MCF7 cells assessed as depletion of cellular level of IGF1R at 0.1 uM by chemiluminescence assay2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID312048Antiproliferative activity against human MCF7 cells by MTT assay2007Journal of natural products, Dec, Volume: 70, Issue:12
Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.
AID379405Antiproliferative activity against human MCF7 cells by MTT assay2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID379397Inhibition of Hsp90 in rabbit reticulocyte lysate assessed as inhibition of heat-denatured firefly luciferase renaturation relative to geldanamycin2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID312047Antiproliferative activity against human NCI-H460 cells by MTT assay2007Journal of natural products, Dec, Volume: 70, Issue:12
Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.
AID379395Cytotoxicity against in mouse 3T3-Y9/B12 cells at 10 uM2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID379403Inhibition of Hsp90 in human MCF7 cells assessed as upregulation of Hsp72 expression at 0.1 uM by chemiluminescence assay2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID427105Cytotoxicity against human dermal papilla cells by Alamar blue assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity.
AID1378625Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
AID1378626Cytotoxicity against human A549 cells after 72 hrs by MTT assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
AID379401Inhibition of Hsp90 in human MCF7 cells assessed as depletion of cellular level of ER at 0.1 uM by chemiluminescence assay2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID379394Induction of heat shock response in mouse 3T3-Y9/B12 cells at 5 uM by fluorescence technique relative to geldanamycin2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID312049Antiproliferative activity against human SF268 cells by MTT assay2007Journal of natural products, Dec, Volume: 70, Issue:12
Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.
AID379402Inhibition of Hsp90 in human MCF7 cells assessed as depletion of cellular level of ER at 1 uM by chemiluminescence assay2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID1378628Antifungal activity against Peronophythora litchii after 8 hrs by conidial germination assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
AID379396Inhibition of Hsp90 in rabbit reticulocyte lysate assessed as inhibition of heat-denatured firefly luciferase renaturation at 10 uM relative to geldanamycin2006Journal of natural products, Feb, Volume: 69, Issue:2
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
AID427104Inhibition of WNT5A mRNA expression in human dermal papilla cells after 24 hrs by quantigene assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity.
AID1378629Antifungal activity against Fusarium verticillioides after 8 hrs by conidial germination assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
AID1378627Cytotoxicity against human HeLa cells after 72 hrs by MTT assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (80.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.85 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thiram
Thiram: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.. thiram : An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.		2.1510organic disulfideantibacterial drug;
antifungal agrochemical;
antiseptic drug
taleranol
taleranol: a metabolite of ZEARALENONE which is a non-steroidal estrogenic lactone used as an anabolic compound in animal feed; a stereoisomer of ZERANOL (alpha-zearalanol)		2.0310macrolide
Zearalanone
[no description available]		2.0310macrolide;
resorcinols
doxorubicin hydrochloride
[no description available]		2.1510anthracycline
zeranol
Zeranol: A non-steroidal estrogen analog.		2.0310macrolide
zearalenone
Zearalenone: (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.. zearalenone : A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.		2.4420macrolide;
resorcinols		fungal metabolite;
mycoestrogen
monorden
monorden: inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II		3.4370cyclic ketone;
enone;
epoxide;
macrolide antibiotic;
monochlorobenzenes;
phenols		antifungal agent;
metabolite;
tyrosine kinase inhibitor
monocillin ii
monocillin II: structure in first source		2.4520
hypothemycin
hypothemycin: a resorcylic acid lactone antibiotic; antifungal metabolite from Hypomyces trichothecoides. hypothemycin : A macrolide that is isolated from the cultured broth of Hypomyces subiculosus and shows antifungal activity and inhibits the growth of some human cancer cells.		2.1510aromatic ether;
diol;
enone;
epoxide;
macrolide;
phenols;
polyketide;
secondary alpha-hydroxy ketone		antifungal agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
fungal metabolite
pochonin d
pochonin D: secondary metabolite of Pochonia chlamydosporia; structure in first source		2.0410
monocillin iii
monocillin III: structure in first source		2.9740
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.0310
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0310