Compounds > monocillin iii
Page last updated: 2024-11-13

monocillin iii

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

monocillin III: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID23305941
CHEMBL ID404204
MeSH IDM0545265

Synonyms (3)

Synonym
monocillin iii
CHEMBL404204
(4r,6r,8r,11e)-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),11,16,18-tetraene-2,13-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID1378626Cytotoxicity against human A549 cells after 72 hrs by MTT assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
AID1378627Cytotoxicity against human HeLa cells after 72 hrs by MTT assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
AID427105Cytotoxicity against human dermal papilla cells by Alamar blue assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity.
AID1378628Antifungal activity against Peronophythora litchii after 8 hrs by conidial germination assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
AID1378625Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
AID312050Induction of heat shock in mouse 3T3-Y9/B12 reporter cells at 5 uM by heat shock induction assay2007Journal of natural products, Dec, Volume: 70, Issue:12
Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.
AID312048Antiproliferative activity against human MCF7 cells by MTT assay2007Journal of natural products, Dec, Volume: 70, Issue:12
Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.
AID312049Antiproliferative activity against human SF268 cells by MTT assay2007Journal of natural products, Dec, Volume: 70, Issue:12
Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.
AID355999Selectivity index, ratio of cytotoxicity against african green monkey Vero cells to IC50 for HSV1 F2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
AID1378629Antifungal activity against Fusarium verticillioides after 8 hrs by conidial germination assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
AID427104Inhibition of WNT5A mRNA expression in human dermal papilla cells after 24 hrs by quantigene assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity.
AID356005Antiparasitic activity against Eimeria tenella Houghton infected in PCKC at 1 ppm treated 2 hrs postinfection by MMDA assay2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
AID312047Antiproliferative activity against human NCI-H460 cells by MTT assay2007Journal of natural products, Dec, Volume: 70, Issue:12
Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.
AID355998Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
AID356006Antiparasitic activity against Neospora caninum NC-1 infected in african green monkey Vero cells treated 2 hrs postinfection by MMDA assay2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
AID356008Agonist activity at ERbeta up to 10 uM by fluorescence polarization assay2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thiram
Thiram: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.. thiram : An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.		2.1510organic disulfideantibacterial drug;
antifungal agrochemical;
antiseptic drug
taleranol
taleranol: a metabolite of ZEARALENONE which is a non-steroidal estrogenic lactone used as an anabolic compound in animal feed; a stereoisomer of ZERANOL (alpha-zearalanol)		2.0110macrolide
Zearalanone
[no description available]		2.0110macrolide;
resorcinols
doxorubicin hydrochloride
[no description available]		2.1510anthracycline
zeranol
Zeranol: A non-steroidal estrogen analog.		2.0110macrolide
zearalenone
Zearalenone: (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.. zearalenone : A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.		2.0110macrolide;
resorcinols		fungal metabolite;
mycoestrogen
monorden
monorden: inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II		3.1450cyclic ketone;
enone;
epoxide;
macrolide antibiotic;
monochlorobenzenes;
phenols		antifungal agent;
metabolite;
tyrosine kinase inhibitor
monocillin i
monocillin I: structure in first source		2.9740
monocillin ii
monocillin II: structure in first source		2.7330
pseurotin
pseurotin: metabolite isolated from culture filtrates of Pseudeurotium ovalis Stolk; structure. pseurotin A : A spirocyclic that is 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione bearing 1,2-dihydroxyhex-3-en-1-yl, methyl, methoxy, benzoyl and hydroxy substituents at positions 2, 3, 8, 8 and 9 respectively.		2.0110azaspiro compound;
lactam;
oxaspiro compound		metabolite
hypothemycin
hypothemycin: a resorcylic acid lactone antibiotic; antifungal metabolite from Hypomyces trichothecoides. hypothemycin : A macrolide that is isolated from the cultured broth of Hypomyces subiculosus and shows antifungal activity and inhibits the growth of some human cancer cells.		2.1510aromatic ether;
diol;
enone;
epoxide;
macrolide;
phenols;
polyketide;
secondary alpha-hydroxy ketone		antifungal agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
fungal metabolite
pochonin d
pochonin D: secondary metabolite of Pochonia chlamydosporia; structure in first source		2.0110
ConditionIndicatedRelationship StrengthStudiesTrials