Bikaverin is a red pigment produced by the fungus Fusarium moniliforme. It exhibits a variety of biological activities, including antifungal, antibacterial, and cytotoxic effects. Bikaverin is known to inhibit the growth of various pathogenic fungi, including Candida albicans and Aspergillus fumigatus. It also shows activity against some bacteria, including Staphylococcus aureus and Escherichia coli. Bikaverin has attracted attention for its potential as an anticancer agent. Studies have shown that it can induce apoptosis (programmed cell death) in cancer cells and inhibit their proliferation. Bikaverin's mechanism of action involves interfering with the production of certain proteins crucial for cell growth and survival. Further research is needed to fully understand its therapeutic potential.'
bikaverin : A organic heterotetracyclic compound that is 10H-benzo[b]xanthene-7,10,12-trione substituted by hydroxy groups at positions 6 and 11, methoxy groups at positions 3 and 8 and a methyl group at position 1. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 36433 |
| CHEMBL ID | 373432 |
| CHEBI ID | 3096 |
| MeSH ID | M0040347 |
| Synonym |
|---|
| NSC215139 , |
| lycopersin |
| 10h-benzo[b]xanthene-7,12-trione, 6,11-dihydroxy-3,8-dimethoxy-1-methyl- |
| nsc-215139 |
| NCI60_001795 |
| 10h-benzo(b)xanthene-7,10,12-trione, 6,11-dihydroxy-3,8-dimethoxy-1-methyl- |
| brn 0358013 |
| 7,10-dihydro-6,11-dihydroxy-3,8-dimethoxy-1-methyl-12h-benzo(b)xanthene-7,10,12-trione |
| 6,11-dihydroxy-3,8-dimethoxy-1-methyl-10h-benzo(b)xanthene-7,10,12-trione |
| nsc 215139 |
| NEURO_000112 |
| 33390-21-5 |
| bikaverin |
| chebi:3096 , |
| CHEMBL373432 |
| 5-18-05-00692 (beilstein handbook reference) |
| f1n6bx58pj , |
| unii-f1n6bx58pj |
| 6,11-dihydroxy-3,8-dimethoxy-1-methyl-10h-benzo[b]xanthene-7,10,12-trione |
| HB3801 |
| ZOQMSOSJEWBMHP-UHFFFAOYSA-N |
| 6,11-dihydroxy-3,8-dimethoxy-1-methyl-benzo[b]xanthene-7,10,12-trione |
| DTXSID80187020 |
| J-019172 |
| Q27105942 |
| HY-121004 |
| CS-0078923 |
| 6,11-dihydroxy-3,8-dimethoxy-1-methyl-7h-benzo[b]xanthene-7,10,12-trione |
| 7,10-dihydroxy-3,8-dimethoxy-1-methylbenzo[b]xanthene-6,11,12-trione |
| GLXC-15007 |
| AKOS040747975 |
Bikaverin is a reddish pigment produced by different fungal species, most of them from the genus Fusarium. It has antibiotic properties against certain protozoa and fungi.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Bikaverin is a red metabolite present mainly in species of the genus Fusarium." | ( Natural blue pigments and bikaverin. Bicas, JL; Santos, MCD, 2021) | 1.64 |
| "Bikaverin is a polyketide having antitumor and antibiotic potential." | ( siRNA mediated gene silencing in Fusarium sp. HKF15 for overproduction of bikaverin. Deshmukh, R; Purohit, HJ, 2014) | 1.35 |
| "Bikaverin is a reddish pigment produced by different fungal species, most of them from the genus Fusarium, with antibiotic properties against certain protozoa and fungi. " | ( Bikaverin production and applications. Avalos, J; Limón, MC; Rodríguez-Ortiz, R, 2010) | 3.25 |
| "Bikaverin is a polyketide-derived pigment produced by multiple species of the fungus Fusarium, some of which can cause ear and kernel rot of maize. " | ( LC-MS/MS method for the determination of the fungal pigment bikaverin in maize kernels as an indicator of ear rot. Busman, M; Butchko, RA; Proctor, RH, 2012) | 2.06 |
Bikaverin pretreatment potentiated the H2O2-induced neuronal markers, such as BDNF, TH, and AADC expression. Treatment with bikaversin at 300 microg ml(-1) suppressed the development of tomato late blight by 71%.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Bikaverin pretreatment efficiently potentiated the H2O2-induced neuronal markers, such as BDNF, TH, and AADC expression, which orchestrate the neuronal damage of the cell." | ( Neuroprotective effects of bikaverin on H2O2-induced oxidative stress mediated neuronal damage in SH-SY5Y cell line. Chandranayaka, S; Jameel, NM; Nirmaladevi, D; Ramesha, A; Srinivas, C; Venkataramana, M, 2014) | 1.42 |
| "Treatment with bikaverin at 300 microg ml(-1) suppressed the development of tomato late blight by 71%." | ( Bikaverin and fusaric acid from Fusarium oxysporum show antioomycete activity against Phytophthora infestans. Choi, GJ; Jang, KS; Kim, HY; Kim, JC; Lee, S; Lee, SO; Lim, HK; Son, SW; Sung, ND, 2008) | 2.13 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (5.26) | 18.7374 |
| 1990's | 3 (7.89) | 18.2507 |
| 2000's | 8 (21.05) | 29.6817 |
| 2010's | 19 (50.00) | 24.3611 |
| 2020's | 6 (15.79) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (29.69) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (7.14%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 39 (92.86%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||