| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
ro 5-4864
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor | 2.36 | 2 | 0 | | |
carbazilquinone
Carbazilquinone: An alkylating agent structurally similar to MITOMYCIN and found to be effective in the treatment of leukemia and various other neoplasms in mice. It causes leukemia and thrombocytopenia in almost all human patients. | 3.07 | 1 | 0 | organic molecular entity | |
clonazepam
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.. clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation. | 4.17 | 5 | 0 | 1,4-benzodiazepinone;
monochlorobenzenes | anticonvulsant;
anxiolytic drug;
GABA modulator |
nordazepam
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.. nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety. | 4.17 | 5 | 0 | 1,4-benzodiazepinone;
organochlorine compound | anticonvulsant;
anxiolytic drug;
GABA modulator;
human metabolite;
sedative |
diazepam
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5. | 4.45 | 7 | 0 | 1,4-benzodiazepinone;
organochlorine compound | anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic |
fludiazepam
fludiazepam: RN given refers to parent cpd; structure | 3.75 | 3 | 0 | 1,4-benzodiazepinone;
organochlorine compound;
organofluorine compound | anxiolytic drug |
flumazenil
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.. flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose. | 1.96 | 1 | 0 | ethyl ester;
imidazobenzodiazepine;
organofluorine compound | antidote to benzodiazepine poisoning;
GABA antagonist |
flunitrazepam
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.. flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia. | 4.45 | 7 | 0 | 1,4-benzodiazepinone;
C-nitro compound;
monofluorobenzenes | anxiolytic drug;
GABAA receptor agonist;
sedative |
flurazepam
Flurazepam: A benzodiazepine derivative used mainly as a hypnotic.. flurazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a 2-(diethylamino)ethyl group, 2-fluorophenyl group and chloro group at positions 1, 5 and 7, respectively. It is a partial agonist of GABAA receptors and used for the treatment of insomnia. | 3.47 | 2 | 0 | 1,4-benzodiazepinone;
monofluorobenzenes;
organochlorine compound;
tertiary amino compound | anticonvulsant;
anxiolytic drug;
GABAA receptor agonist;
sedative |
lorazepam
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. | 2.39 | 2 | 0 | benzodiazepine | |
nimetazepam
nimetazepam : A nitrazepam which is substituted at positions 1 by a methyl group. It is used as an anticonvulsant and as a hypnotic for the short-term management of insomnia. | 3.75 | 3 | 0 | 1,4-benzodiazepinone;
C-nitro compound | anticonvulsant;
antispasmodic drug;
GABA modulator;
sedative |
nitrazepam
Nitrazepam: A benzodiazepine derivative used as an anticonvulsant and hypnotic.. nitrazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome). | 4.17 | 5 | 0 | 1,4-benzodiazepinone;
C-nitro compound | anticonvulsant;
antispasmodic drug;
drug metabolite;
GABA modulator;
sedative |
cm 7116
norflutoprazepam: structure | 3.99 | 4 | 0 | benzodiazepine | |
oxazepam
Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.. oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5. | 2.39 | 2 | 0 | 1,4-benzodiazepinone;
organochlorine compound | anxiolytic drug;
environmental contaminant;
xenobiotic |
prazepam
Prazepam: A benzodiazepine that is used in the treatment of ANXIETY DISORDERS. | 3.07 | 1 | 0 | benzodiazepine | |
temazepam
Temazepam: A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent. | 2.39 | 2 | 0 | benzodiazepine | |
triaziquone
Triaziquone: Alkylating antineoplastic agent used mainly for ovarian tumors. It is toxic to skin, gastrointestinal tract, bone marrow and kidneys.. triaziquone : A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which three of the ring hydrogens are replaced by aziridin-1-yl groups. | 3.07 | 1 | 0 | 1,4-benzoquinones;
aziridines | alkylating agent;
antineoplastic agent |
benzylamine
aminotoluene : Any member of the class of toluenes carrying one or more amino groups. | 1.96 | 1 | 0 | aralkylamine;
primary amine | allergen;
EC 3.5.5.1 (nitrilase) inhibitor;
plant metabolite |
chlordesmethyldiazepam
[no description available] | 3.99 | 4 | 0 | benzodiazepine | |
halazepam
halazepam: structure | 2.39 | 2 | 0 | organic molecular entity | |
4-methylbenzylamine
[no description available] | 1.96 | 1 | 0 | | |
4-fluorobenzylamine
[no description available] | 1.96 | 1 | 0 | | |
4-methoxybenzylamine
1-(4-methoxyphenyl)methanamine : An aralkylamino compound that is benzylamine substituted by a methoxy group at the para position. | 1.96 | 1 | 0 | aralkylamino compound;
aromatic ether;
primary amino compound | |
n-desmethylflunitrazepam
[no description available] | 4.17 | 5 | 0 | | |
7-bromo-5-phenyl-1,2-dihydro-2h-1,4-benzodiazepin-2-one
7-bromo-5-phenyl-1,2-dihydro-2H-1,4-benzodiazepin-2-one: RN given refers to unlabeled parent cpd | 3.46 | 2 | 0 | | |
2-chlorodiazepam
[no description available] | 3.75 | 3 | 0 | | |
7-aminonitrazepam
7-aminonitrazepam: urinary metabolite of nitrazepam | 2.39 | 2 | 0 | benzodiazepine | |
ro 20-1815
7-aminoflunitrazepam: flunitrazepam metabolite; structure given in first source | 2.39 | 2 | 0 | benzodiazepine | |
ro 11-6893
Ro 11-6893: RN given refers to (R)-isomer | 2.38 | 2 | 0 | | |
2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone
2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone: structure given in first source | 3.07 | 1 | 0 | | |
7-aminoclonazepam
[no description available] | 2.39 | 2 | 0 | benzodiazepine | |
l 365031
L 365031: CCK antagonist | 1.97 | 1 | 0 | | |
devazepide
Devazepide: A derivative of benzodiazepine that acts on the cholecystokinin A (CCKA) receptor to antagonize CCK-8's (SINCALIDE) physiological and behavioral effects, such as pancreatic stimulation and inhibition of feeding.. devazepide : An indolecarboxamide obtained by formal condensation of the carboxy group of indole-2-carboxylic acid with the exocyclic amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one. A cholecystokinin antagonist used for treatment of gastrointestinal disorders. | 1.97 | 1 | 0 | 1,4-benzodiazepinone;
indolecarboxamide | antineoplastic agent;
apoptosis inducer;
cholecystokinin antagonist;
gastrointestinal drug |
n-desmethylflunitrazepam
N-desmethylflunitrazepam: metabolite of flunitrazepam | 3.99 | 4 | 0 | | |
ro 05-4082
ID 690: methyl deriv of clonazepam; structure | 4.17 | 5 | 0 | | |
7-methyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
[no description available] | 1.95 | 1 | 0 | benzodiazepine | |
meclonazepam
[no description available] | 1.98 | 1 | 0 | | |
sancycline
sancycline: RN given refers to parent cpd | 1.96 | 1 | 0 | | |