Compounds > goadsporin
Page last updated: 2024-10-15

goadsporin

Description

goadsporin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID139586753
MeSH IDM0417079

Synonyms (1)

Synonym
goadsporin

Research Excerpts

Overview

Goadsporin is a linear azole containing peptide that is biosynthesized via a ribosome-mediated pathway in Streptomyces sp. It is a thiopeptide containing thiazole and oxazole heterocyclic rings.

ExcerptReference
"Goadsporin is a chemical substance isolated from Streptomyces sp."( Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes.
Onaka, H, 2017)
"Goadsporin is a linear azole containing peptide that is biosynthesized via a ribosome-mediated pathway in Streptomyces sp."( Genetic approaches to generate hyper-producing strains of goadsporin: the relationships between productivity and gene duplication in secondary metabolite biosynthesis.
Asamizu, S; Furumai, T; Haginaka, K; Igarashi, Y; Onaka, H; Ozaki, T, 2014)
"Goadsporin (GS) is a member of ribosomally synthesized and post-translationally modified peptides (RiPPs), containing an N-terminal acetyl moiety, six azoles and two dehydroalanines in the peptidic main chain. "( Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo.
Asamizu, S; Goto, Y; Hayashi, S; Ikeda, H; Onaka, H; Ozaki, T; Shimomura, M; Suga, H; Sugai, Y; Yamashita, K, 2017)
"Goadsporin is a thiopeptide containing thiazole and oxazole heterocyclic rings."( Biosynthesis of indolocarbazole and goadsporin, two different heterocyclic antibiotics produced by actinomycetes.
Onaka, H, 2009)
"Goadsporin is an oligopeptide consisting of 19 amino acids with the molecular formula C72H97N19020S2."( Goadsporin, a chemical substance which promotes secondary metabolism and morphogenesis in streptomycetes. I. Purification and characterization.
Furumai, T; Igarashi, Y; Onaka, H; Sato, Y; Tabata, H, 2001)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (40.00)29.6817
2010's6 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (30.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (70.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		7.1310alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		3.1610butan-4-olidemetabolite;
neurotoxin
rebeccamycin
rebeccamycin: from actinomycete strain C-38,383; structure given in first source. rebeccamycin : An N-glycosyl compound consisting of a heteropolycyclic ring system with a glucosyl group attached to one of the indolic nitrogens.		3.1410indolocarbazole;
N-glycosyl compound;
organic heterohexacyclic compound;
organochlorine compound
dehydroalanine
2-ammonioprop-2-enoate : An amino acid zwitterion resulting from a transfer of a proton from the carboxy group to the amino group of 2-aminoacrylic acid.. 2-aminoacrylic acid : A 2,3-dehydroamino acid that is alanine which has been dehydrogenated to introduce a double bond between positions 2 and 3.		7.13102,3-dehydroamino acid;
alpha,beta-unsaturated monocarboxylic acid;
amino acid zwitterion;
enamine;
non-proteinogenic alpha-amino acid		alkylating agent;
human metabolite;
mouse metabolite
staurosporine
staurosporinium : Conjugate acid of staurosporine.		3.1410ammonium ion derivative
ConditionIndicatedRelationship StrengthStudiesTrials