Page last updated: 2024-11-13

pacidamycin d

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pacidamycin D: isolated from the fermentation broth of the Streptomyces coeruleorubiduns strain; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID56590296
CHEMBL ID2048825
MeSH IDM0569822

Synonyms (3)

Synonym
bdbm50386961
CHEMBL2048825 ,
pacidamycin d
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Phospho-N-acetylmuramoyl-pentapeptide-transferaseStaphylococcus aureusIC50 (µMol)0.02200.02200.17600.3300AID670374
Delta-type opioid receptorRattus norvegicus (Norway rat)IC50 (µMol)0.02200.00030.38877.0000AID670374
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID670377Antimicrobial activity against Pseudomonas aeruginosa ATCC 25619 incubated at 35 degC for 20 hrs by microdilution broth method2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction.
AID670375Antimicrobial activity against Pseudomonas aeruginosa PAO1 incubated at 35 degC for 20 hrs by microdilution broth method2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction.
AID670378Antimicrobial activity against Pseudomonas aeruginosa SR 27156 incubated at 35 degC for 20 hrs by microdilution broth method2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction.
AID670376Antimicrobial activity against Pseudomonas aeruginosa YYI65 (deltamexB) incubated at 35 degC for 20 hrs by microdilution broth method2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction.
AID670374Inhibition of Staphylococcus aureus MraY using UDP-MurNAc-dansylpentapeptide substrate assessed as formation of dansylated lipid I incubated for 3 to 4 hrs by fluorometric assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]