chromopyrrolic acid

Description

chromopyrrolic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

chromopyrrolic acid : A pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced by indol-3-yl groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	11326613
CHEMBL ID	491841
CHEBI ID	41625
SCHEMBL ID	12955978
MeSH ID	M0537006

Synonyms (16)

Synonym
chromopyrrolic acid
3,4-di-1h-indol-3-yl-1h-pyrrole-2,5-dicarboxylic acid
DB07588
lycogalic acid a
CHEMBL491841
bdbm50378456
lycogaric acid a
150044-68-1
1h-pyrrole-2,5-dicarboxylic acid, 3,4-di-1h-indol-3-yl-
SCHEMBL12955978
DTXSID90462496
C21125
CHEBI:41625
3,4-di(1h-indol-3-yl)-1h-pyrrole-2,5-dicarboxylic acid
3,4-di(indol-3-yl)pyrrole-2,5-dicarboxylic acid
Q27096807

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
bacterial metabolite	Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

Class	Description
indoles	Any compound containing an indole skeleton.
pyrroledicarboxylic acid	A pyrrole compound having two carboxy substituents at any position on the ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Transcription factor HES-1	Mus musculus (house mouse)	IC50 (µMol)	6.0000	6.0000	6.0000	6.0000	AID447680
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Process	via Protein(s)	Taxonomy
nucleoplasm	Transcription factor HES-1	Mus musculus (house mouse)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID447683	Inhibition of mouse Hes1-mediated suppression of basic helix-loop-helix activator genes in C3H10T1/2 cells at 50 uM by luciferase transactivation assay	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19	The first Hes1 dimer inhibitors from natural products.
AID447680	Inhibition of Cy3-labeled mouse recombinant Hes1 (3-281) dimer formation expressed in Escherichia coli by microplate-based assay	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19	The first Hes1 dimer inhibitors from natural products.
AID391903	Antiviral activity against HSV	2008	Journal of natural products, Oct, Volume: 71, Issue:10	Lynamicins A-E, chlorinated bisindole pyrrole antibiotics from a novel marine actinomycete.
AID447682	Inhibition of mouse Hes1-mediated suppression of basic helix-loop-helix activator genes in C3H10T1/2 cells by luciferase transactivation assay	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19	The first Hes1 dimer inhibitors from natural products.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (57.14)	29.6817
2010's	3 (42.86)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
staurosporine aglycone staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor	2.45	2
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	2.48	2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	3.32	6	pyrrole; secondary amine
manganese Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.	2.1	1	elemental manganese; manganese group element atom	Escherichia coli metabolite; micronutrient
rebeccamycin rebeccamycin: from actinomycete strain C-38,383; structure given in first source. rebeccamycin : An N-glycosyl compound consisting of a heteropolycyclic ring system with a glucosyl group attached to one of the indolic nitrogens.	7.11	1	indolocarbazole; N-glycosyl compound; organic heterohexacyclic compound; organochlorine compound
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	2.05	1
lycogarubin c lycogarubin C: structure in first source	7.97	4
lyoniside lyoniside: see also eleutherosides & syringin for eleutheroside B: 118-34-3; RN given refers to (3beta)-isomer	2.05	1

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