Page last updated: 2024-10-06

rebeccamycin biosynthesis

Proteins (7)

ProteinSynonymsTaxonomy
Flavin-dependent L-tryptophan oxidase RebOEC 1.4.3.23; L-amino acid oxidase protein; L-AAOLentzea aerocolonigenes
Flavin-dependent tryptophan halogenase RebHEC 1.14.19.9Lentzea aerocolonigenes
Demethylrebeccamycin-D-glucose O-methyltransferaseEC 2.1.1.164; Rebeccamycin O-methyltransferase; Rebeccamycin sugar 4'-O-methyltransferase RebMLentzea aerocolonigenes
4'-demethylrebeccamycin synthaseEC 4.3.3.5; Arcyriaflavin A N-glycosyltransferaseLentzea aerocolonigenes
Dichlorochromopyrrolate synthaseEC 1.21.98.2; Catalase; 1.11.1.6Lentzea aerocolonigenes
Putative FAD-monooxygenase Lentzea aerocolonigenes
Cytochrome P-450 RebP Lentzea aerocolonigenes

Compounds (14)

CompoundDescription
hydronium ion
NADH
Ammonium
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
chlorineAn element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.
GlucoseA primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
1,5-dihydro-FADchromophore component of E coli DNA photolyase
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
rebeccamycinfrom actinomycete strain C-38,383; structure given in first source
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)