Page last updated: 2024-10-06

superpathway of aromatic compound degradation via 3-oxoadipate

Proteins (36)

ProteinSynonymsTaxonomy
Mandelate racemaseMR; EC 5.1.2.2Pseudomonas putida
p-hydroxybenzoate hydroxylasePHBH; PHBHase; EC 1.14.13.2; 4-hydroxybenzoate 3-monooxygenasePseudomonas fluorescens
Muconolactone Delta-isomeraseMIase; EC 5.3.3.4Pseudomonas putida
MetapyrocatechaseMPC; EC 1.13.11.2; CatO2ase; Catechol 2,3-dioxygenasePseudomonas putida
Protocatechuate 3,4-dioxygenase alpha chainEC 1.13.11.3; 3,4-PCDPseudomonas putida
Protocatechuate 3,4-dioxygenase beta chainEC 1.13.11.3; 3,4-PCDPseudomonas putida
Beta-ketoadipyl-CoA thiolaseEC 2.3.1.174; 3-oxoadipyl-CoA thiolasePseudomonas putida
Benzoylformate decarboxylaseBFD; BFDC; EC 4.1.1.7Pseudomonas putida
3-dehydroshikimate dehydratase3-DHS dehydratase; DHSase; EC 4.2.1.118Acinetobacter baylyi ADP1
Catabolic 3-dehydroquinate dehydratase3-dehydroquinase; EC 4.2.1.10Acinetobacter baylyi ADP1
KynureninaseEC 3.7.1.3; L-kynurenine hydrolasePseudomonas fluorescens
4-hydroxy-2-oxovalerate aldolase 1HOA 1; EC 4.1.3.39; 4-hydroxy-2-keto-pentanoic acid aldolase 1; 4-hydroxy-2-oxopentanoate aldolase 1Pseudomonas putida F1
4-hydroxy-2-oxovalerate aldolaseHOA; EC 4.1.3.39; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolasePseudomonas putida
Anthranilate 1,2-dioxygenase large subunitEC 1.14.12.1Acinetobacter baylyi ADP1
Anthranilate 1,2-dioxygenase small subunitEC 1.14.12.1Acinetobacter baylyi ADP1
1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenaseEC 1.3.1.25; 2-hydro-1,2-dihydroxybenzoate dehydrogenase; DHB dehydrogenase; Cis-1,2-dihydroxy-3,4-cyclohexadiene-1-carboxylate dehydrogenase; Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenasePseudomonas putida
Anthranilate 1,2-dioxygenase electron transfer componentAcinetobacter baylyi ADP1
4-carboxymuconolactone decarboxylaseCMD; EC 4.1.1.44Pseudomonas putida
Muconate cycloisomerase 1EC 5.5.1.1; Cis,cis-muconate lactonizing enzyme I; MLE; Muconate cycloisomerase IPseudomonas putida
3-oxoadipate CoA-transferase subunit BEC 2.8.3.6; Beta-ketoadipate:succinyl-CoA transferase subunit BPseudomonas putida
Toluate 1,2-dioxygenase subunit alphaEC 1.14.12.-Pseudomonas putida
Toluate 1,2-dioxygenase subunit betaEC 1.14.12.-Pseudomonas putida
Toluate 1,2-dioxygenase electron transfer componentPseudomonas putida
2-hydroxypent-2,4-dienoate hydrataseHPH; EC 4.2.-.-; 2-oxopent-4-enoate hydratasePseudomonas putida
Benzaldehyde dehydrogenase [NAD(+)]EC 1.2.1.28Pseudomonas putida
3-oxoadipate CoA-transferase subunit AEC 2.8.3.6; Beta-ketoadipate:succinyl-CoA transferase subunit APseudomonas putida
Quinate/shikimate dehydrogenase (quinone)EC 1.1.5.8; NAD(P)-independent quinate dehydrogenaseAcinetobacter baylyi ADP1
NAD(P)-dependent benzaldehyde dehydrogenaseEC 1.2.1.28; EC 1.2.1.7Pseudomonas putida
Catechol 1,2-dioxygenase Pseudomonas putida
Acetaldehyde dehydrogenase Pseudomonas putida
PobA proteinPseudomonas putida
3-oxoadipate enol-lactonase 2 Pseudomonas putida KT2440
(S)-mandelate dehydrogenaseEC 1.1.99.31; L(+)-mandelate dehydrogenase; MDHPseudomonas putida
3-carboxy-cis,cis-muconate cycloisomeraseEC 5.5.1.2; 3-carboxymuconate lactonizing enzyme; CMLEPseudomonas putida
2-hydroxymuconate semialdehyde hydrolaseHMSH; EC 3.7.1.9; 2-hydroxymuconic semialdehyde hydrolasePseudomonas putida
4-nitrobenzaldehyde dehydrogenase NtnC

Compounds (51)

CompoundDescription
diphosphoric acid
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
RubidiumAn element that is an alkali metal. It has an atomic symbol Rb, atomic number 37, and atomic weight 85.47. It is used as a chemical reagent and in the manufacture of photoelectric cells.
Succinate
NADH
Ammonium
CopperA heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
carbon monoxideCarbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
fluoridesInorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.
IronA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
iodineA nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
chlorineAn element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.
Orthophosphate
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
potassium chlorideA white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
potassiumAn element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
NickelA trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
succinyl-coenzyme A
salicylatesThe salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
nedocromilA pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including EOSINOPHILS; NEUTROPHILS; MACROPHAGES; MAST CELLS; MONOCYTES; AND PLATELETS.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
4-hydroxybenzaldehyde
4-hydroxybenzoic acid
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
acetaldehydeA colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
benzaldehydeRN given refers to parent cpd; structure
Benzoate
formate
catecholRN given refers to unlabeled parent cpd
4-fluorobenzoate
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
4-aminobenzoic acidAn aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.
Edetic AcidA chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
anthranilate
TolbutamideA sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
3-dehydroshikimate
hydrogen cyanideHydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.
Quinate
PQQ CofactorA pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES.
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)