| Protein | Synonyms | Taxonomy |
|---|
| o-succinylbenzoate synthase | OSB synthase; OSBS; EC 4.2.1.113; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthase | Escherichia coli K-12 |
| 3-dehydroquinate synthase | DHQS; EC 4.2.3.4 | Escherichia coli K-12 |
| 3-phosphoshikimate 1-carboxyvinyltransferase | EC 2.5.1.19; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS | Escherichia coli K-12 |
| Farnesyl diphosphate synthase | FPP synthase; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase | Escherichia coli K-12 |
| Dihydrofolate reductase | EC 1.5.1.3 | Escherichia coli K-12 |
| Enterobactin synthase component B | EC 6.3.2.14; Enterobactin biosynthesis bifunctional protein EntB; Enterochelin synthase B | Escherichia coli K-12 |
| Dihydrofolate synthase/folylpolyglutamate synthase | DHFS / FPGS; EC 6.3.2.12; EC 6.3.2.17; Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase; Folylpolyglutamate synthetase; Tetrahydrofolylpolyglutamate synthase | Escherichia coli K-12 |
| Octaprenyl diphosphate synthase | EC 2.5.1.90; All-trans-octaprenyl-diphosphate synthase; Octaprenyl pyrophosphate synthase; OPP synthase | Escherichia coli K-12 |
| Aminodeoxychorismate lyase | EC 4.1.3.38; 4-amino-4-deoxychorismate lyase; ADC lyase; ADCL | Escherichia coli K-12 |
| 1,4-dihydroxy-2-naphthoate octaprenyltransferase | DHNA-octaprenyltransferase; EC 2.5.1.74 | Escherichia coli K-12 |
| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | EC 2.7.6.3; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK | Escherichia coli K-12 |
| Dihydropteroate synthase | DHPS; EC 2.5.1.15; Dihydropteroate pyrophosphorylase | Escherichia coli K-12 |
| 3-dehydroquinate dehydratase | 3-dehydroquinase; EC 4.2.1.10; Type I DHQase; Type I dehydroquinase; DHQ1 | Escherichia coli K-12 |
| Aspartate aminotransferase | AspAT; EC 2.6.1.1; Transaminase A | Escherichia coli K-12 |
| Branched-chain-amino-acid aminotransferase | BCAT; EC 2.6.1.42; Transaminase B | Escherichia coli K-12 |
| Chorismate synthase | CS; EC 4.2.3.5; 5-enolpyruvylshikimate-3-phosphate phospholyase; EPSP phospholyase | Escherichia coli K-12 |
| Tryptophan synthase alpha chain | EC 4.2.1.20 | Escherichia coli K-12 |
| Tryptophan synthase beta chain | EC 4.2.1.20 | Escherichia coli K-12 |
| Bifunctional chorismate mutase/prephenate dehydratase | Chorismate mutase-prephenate dehydratase; P-protein | Escherichia coli K-12 |
| Chorismate pyruvate-lyase | CL; CPL; EC 4.1.3.40 | Escherichia coli K-12 |
| Isochorismate synthase EntC | EC 5.4.4.2; Isochorismate mutase | Escherichia coli K-12 |
| Shikimate kinase 1 | SK 1; EC 2.7.1.71; Shikimate kinase I; SKI | Escherichia coli K-12 |
| Shikimate kinase 2 | SK 2; EC 2.7.1.71; Shikimate kinase II; SKII | Escherichia coli K-12 |
| Anthranilate synthase component 1 | AS; ASI; EC 4.1.3.27 | Escherichia coli K-12 |
| GTP cyclohydrolase 1 | EC 3.5.4.16; GTP cyclohydrolase I; GTP-CH-I | Escherichia coli K-12 |
| Dihydromonapterin reductase | H(2)-MPt reductase; EC 1.5.1.50; Dihydrofolate reductase; DHFR; 1.5.1.3 | Escherichia coli K-12 |
| Isopentenyl-diphosphate Delta-isomerase | IPP isomerase; EC 5.3.3.2; IPP:DMAPP isomerase; Isopentenyl pyrophosphate isomerase | Escherichia coli K-12 |
| Aromatic-amino-acid aminotransferase | ARAT; AROAT; EC 2.6.1.57; Beta-methylphenylalanine transaminase; 2.6.1.107 | Escherichia coli K-12 |
| Dihydroneopterin aldolase | DHNA; EC 4.1.2.25; 7,8-dihydroneopterin 2'-epimerase; 7,8-dihydroneopterin aldolase; 7,8-dihydroneopterin epimerase; 5.1.99.8; Dihydroneopterin epimerase | Escherichia coli K-12 |
| 3-octaprenyl-4-hydroxybenzoate carboxy-lyase | EC 4.1.1.98; Polyprenyl p-hydroxybenzoate decarboxylase | Escherichia coli K-12 |
| Isochorismate synthase MenF | EC 5.4.4.2; Isochorismate hydroxymutase; Isochorismate mutase | Escherichia coli K-12 |
| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase | SHCHC synthase; EC 4.2.99.20 | Escherichia coli K-12 |
| 1,4-dihydroxy-2-naphthoyl-CoA synthase | DHNA-CoA synthase; EC 4.1.3.36 | Escherichia coli K-12 |
| Dihydroneopterin triphosphate diphosphatase | EC 3.6.1.67; Dihydroneopterin triphosphate pyrophosphatase; dATP pyrophosphohydrolase | Escherichia coli K-12 |
| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | SEPHCHC synthase; EC 2.2.1.9; Menaquinone biosynthesis protein MenD | Escherichia coli K-12 |
| Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive | EC 2.5.1.54; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase | Escherichia coli K-12 |
| Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive | EC 2.5.1.54; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase | Escherichia coli K-12 |
| Aminodeoxychorismate synthase component 2 | ADC synthase; ADCS; EC 2.6.1.85; 4-amino-4-deoxychorismate synthase component 2; Aminodeoxychorismate synthase, glutamine amidotransferase component | Escherichia coli K-12 |
| Bifunctional protein TrpGD | | Escherichia coli K-12 |
| Tryptophan biosynthesis protein TrpCF | | Escherichia coli K-12 |
| Aminodeoxychorismate synthase component 1 | ADC synthase; ADCS; EC 2.6.1.85; 4-amino-4-deoxychorismate synthase component 1 | Escherichia coli K-12 |
| T-protein | | Escherichia coli K-12 |
| Quinate/shikimate dehydrogenase | EC 1.1.1.282; NAD-dependent shikimate 5-dehydrogenase | Escherichia coli K-12 |
| Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE | EC 2.1.1.163; EC 2.1.1.201; 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase; Demethylmenaquinone methyltransferase | Escherichia coli K-12 |
| Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive | EC 2.5.1.54; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase | Escherichia coli K-12 |
| 4-hydroxybenzoate octaprenyltransferase | EC 2.5.1.39; 4-HB polyprenyltransferase; PHB octaprenyl transferase | Escherichia coli K-12 |
| Enterobactin synthase component F | EC 2.7.7.-; Enterochelin synthase F; Serine-activating enzyme; Seryl-AMP ligase | Escherichia coli K-12 |
| 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase | DiDHB-DH; EC 1.3.1.28; Trans-2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase | Escherichia coli K-12 |
| Shikimate dehydrogenase (NADP(+)) | SD; SDH; EC 1.1.1.25 | Escherichia coli K-12 |
| Ubiquinone biosynthesis O-methyltransferase | 2-octaprenyl-6-hydroxyphenol methylase; 2.1.1.222; 3-demethylubiquinone-8 3-O-methyltransferase; 2.1.1.64 | Escherichia coli K-12 |
| Enterobactin synthase component D | 4'-phosphopantetheinyl transferase EntD; 2.7.8.-; Enterochelin synthase D | Escherichia coli K-12 |
| 2-octaprenyl-6-methoxyphenol hydroxylase | EC 1.14.13.- | Escherichia coli K-12 |
| 2-octaprenylphenol hydroxylase | EC 1.14.13.240; 2-polyprenylphenol 6-hydroxylase | Escherichia coli K-12 |
| 2-succinylbenzoate--CoA ligase | EC 6.2.1.26; o-succinylbenzoyl-CoA synthetase; OSB-CoA synthetase | Escherichia coli K-12 |
| 3-demethoxyubiquinol 3-hydroxylase | EC 1.14.99.60; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase | Escherichia coli K-12 |
| 1,4-dihydroxy-2-naphthoyl-CoA hydrolase | DHNA-CoA hydrolase; EC 3.1.2.28; DHNA-CoA thioesterase | Escherichia coli K-12 |
| Compound | Description |
|---|
| diphosphoric acid | |
| hydronium ion | |
| Cobalt | A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis. |
| Barium | An element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous. |
| Cesium | A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency. |
| Rubidium | An element that is an alkali metal. It has an atomic symbol Rb, atomic number 37, and atomic weight 85.47. It is used as a chemical reagent and in the manufacture of photoelectric cells. |
| Thiamine Pyrophosphate | The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX. |
| Succinate | |
| NADH | |
| ubiquinol | reduced forms of ubiquinone; see also record for ubiquinol 10 |
| Mercury | A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing. |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Manganese | A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035) |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| chlorine | An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family. |
| serum p-component | close relation to C reactive protein; may be ovosomucoid |
| Zinc | A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
| Orthophosphate | |
| Polysorbate 80 | |
| trimethoprim | A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Uridine Triphosphate | Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety. |
| hydrogen carbonate | |
| potassium | An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE. |
| methanol | A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness. |
| Magnesium | A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION. |
| Sodium | A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23. |
| nitrates | Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| indoleglycerol phosphate | inducer of tryptophan synthase |
| 2,3-dihydroxybenzoate | |
| Vanillic Acid | A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13). |
| 1,4-dihydroxy-2-naphthoate | |
| iodoacetamide | An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate. |
| 2,4,6-Trinitrobenzene Sulfonate | |
| 3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate | a surfactant; structure given in first source |
| Pyruvic Acid | An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed) |
| thymidine 5'-triphosphate | RN given refers to parent cpd |
| 4-hydroxybenzaldehyde | |
| 4-hydroxybenzoic acid | |
| Excitatory Postsynaptic Potentials | Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS. |
| mercaptoethanol | A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation. |
| adenosine monophosphate | Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| isopentenyl pyrophosphate | substrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells |
| farnesyl pyrophosphate | a sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation |
| alpha-Ketoglutarate | |
| geranyl diphosphate | structure in first source |
| formate | |
| diethyl pyrocarbonate | Preservative for wines, soft drinks, and fruit juices and a gentle esterifying agent. |
| enterobactin | An iron-binding cyclic trimer of 2,3-dihydroxy-N-benzoyl-L-serine. It is produced by E COLI and other enteric bacteria. |
| Cadaverine | A foul-smelling diamine formed by bacterial decarboxylation of lysine. |
| sodium borohydride | RN given refers to parent cpd |
| ethylmaleimide | A sulfhydryl reagent that is widely used in experimental biochemical studies. |
| dithiothreitol | A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols. |
| 3-phenylpyruvate | |
| 4-aminobenzoic acid | An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS. |
| alpha-keto-isovaleric acid | |
| Edetic Acid | A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive. |
| 2-octaprenyl phenol | biosynthetic precursor of ubiquinone-8 |
| maleate | |
| anthranilate | |
| Tolbutamide | A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290) |
| glutamate | |
| prephenate | |
| 3-dehydroshikimate | |
| isochorismate | |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| octoxynol | Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Octoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide. |
| 4-hydroxyphenylpyruvate | |
| polyglutamine | RN given for (D)-isomer |
| Spermidine | A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine. |
| bromopyruvate | |
| glycolaldehyde | structure |
| indole | RN given refers to parent cpd; structure in Merck Index, 9th ed, #4840 |
| tetranitromethane | Corrosive oxidant, explosive; additive to diesel and rocket fuels; causes skin and lung irritation; proposed war gas. A useful reagent for studying the modification of specific amino acids, particularly tyrosine residues in proteins. Has also been used for studying carbanion formation and for detecting the presence of double bonds in organic compounds. |
| adenosine 3'-phosphate-5'-phosphate | |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| Coenzyme A | |
| glyphosate | active cpd in herbicidal formulation Roundup; inhibits EC 2.5.1.19, 5-enolpyruvylshikimate-3-phosphate synthase; structure |
| flavin mononucleotide hydroquinone | structure in first source |
| Spermine | A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. |