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Methanobacterium thermoautotrophicum biosynthetic metabolism

Proteins (22)

ProteinSynonymsTaxonomy
Carbonic anhydraseMethanothermobacter thermautotrophicus str. Delta H
Geranylgeranylglyceryl phosphate synthaseGGGP synthase; GGGPS; MtGGGPS; EC 2.5.1.41; (S)-3-O-geranylgeranylglyceryl phosphate synthase; Phosphoglycerol geranylgeranyltransferaseMethanothermobacter thermautotrophicus str. Delta H
Digeranylgeranylglyceryl phosphate synthaseDGGGP synthase; DGGGPS; EC 2.5.1.42; (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Geranylgeranylglycerol-phosphate geranylgeranyltransferaseMethanothermobacter thermautotrophicus str. Delta H
Pyruvate synthase subunit PorBEC 1.2.7.1; Pyruvate oxidoreductase beta chain; POR; Pyruvic-ferredoxin oxidoreductase subunit betaMethanothermobacter thermautotrophicus str. Delta H
Pyruvate synthase subunit PorCEC 1.2.7.1; Pyruvate oxidoreductase gamma chain; POR; Pyruvic-ferredoxin oxidoreductase subunit gammaMethanothermobacter thermautotrophicus str. Delta H
Pyruvate synthase subunit PorAEC 1.2.7.1; Pyruvate oxidoreductase alpha chain; POR; Pyruvic-ferredoxin oxidoreductase subunit alphaMethanothermobacter thermautotrophicus str. Delta H
Pyruvate synthase subunit PorDPyruvate oxidoreductase delta chain; POR; Pyruvic-ferredoxin oxidoreductase subunit deltaMethanothermobacter thermautotrophicus str. Delta H
Molybdenum-containing formylmethanofuran dehydrogenase 1 subunit CEC 1.2.7.12; Molybdenum-containing formylmethanofuran dehydrogenase I subunit CMethanothermobacter thermautotrophicus str. Delta H
Triosephosphate isomeraseTIM; TPI; EC 5.3.1.1; Triose-phosphate isomeraseMethanothermobacter thermautotrophicus str. Delta H
EnolaseEC 4.2.1.11; 2-phospho-D-glycerate hydro-lyase; 2-phosphoglycerate dehydrataseMethanothermobacter thermautotrophicus str. Delta H
Pyruvate carboxylase subunit BEC 6.4.1.1; Pyruvic carboxylase BMethanothermobacter thermautotrophicus str. Delta H
Pyruvate carboxylase subunit AEC 6.4.1.1; Pyruvic carboxylase AMethanothermobacter thermautotrophicus str. Delta H
2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2BPG-independent PGAM 2; Phosphoglyceromutase 2; aPGAM 2; EC 5.4.2.12Methanothermobacter thermautotrophicus str. Delta H
CDP-archaeol synthaseEC 2.7.7.67; CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthaseMethanothermobacter thermautotrophicus str. Delta H
Phosphoenolpyruvate carboxylasePEPC; PEPCase; EC 4.1.1.31Methanothermobacter thermautotrophicus str. Delta H
Putative archaetidylserine decarboxylase proenzymeEC 4.1.1.-Methanothermobacter thermautotrophicus str. Delta H
Archaetidylserine synthaseEC 2.7.8.38; CDP-2,3-di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferaseMethanothermobacter thermautotrophicus str. Delta H
5,10-methenyltetrahydromethanopterin hydrogenaseEC 1.12.98.2; H(2)-dependent methylene-H(4)MPT dehydrogenase; H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase; N(5),N(10)-methenyltetrahydromethanopterin hydrogenaseMethanothermobacter thermautotrophicus str. Delta H
2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1BPG-independent PGAM 1; Phosphoglyceromutase 1; aPGAM 1; EC 5.4.2.12Methanothermobacter thermautotrophicus str. Delta H
5,10-methylenetetrahydromethanopterin reductaseEC 1.5.98.2; Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase; Methylene-H(4)MPT reductaseMethanothermobacter thermautotrophicus str. Delta H
Glycerol-1-phosphate dehydrogenase [NAD(P)+]G1P dehydrogenase; G1PDH; EC 1.1.1.261; Enantiomeric glycerophosphate synthase; sn-glycerol-1-phosphate dehydrogenaseMethanothermobacter thermautotrophicus str. Delta H
Short chain isoprenyl diphosphate synthaseEC 2.5.1.-Methanothermobacter marburgensis str. Marburg

Compounds (43)

CompoundDescription
diphosphoric acid
hydronium ion
Succinate
NADH
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
carbon monoxideCarbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
potassium chlorideA white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
Sodium ChlorideA ubiquitous sodium salt that is commonly used to season food.
Aspartate
fumaratesCompounds based on fumaric acid.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
hydrogen carbonate
hydrogenThe first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
potassiumAn element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
succinyl-coenzyme A
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
isopentenyl pyrophosphatesubstrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
farnesyl pyrophosphatea sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation
alpha-Ketoglutarate
OxaloacetateAn anionic form of oxaloacetic acid.
geranyl diphosphatestructure in first source
formate
Mevalonate
glutamate
fructose-1,6-diphosphateRN refers to (D)-isomer
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
geranylgeranyl pyrophosphateRN given refers to (E,E,E)-isomer
Glucose-6-PhosphateAn ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)
Cytidine MonophosphateCytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
Cytidine TriphosphateCytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.
hydrogen cyanideHydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.
Coenzyme A
acetoacetyl CoA
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.