Page last updated: 2024-10-06

superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation

Proteins (18)

ProteinSynonymsTaxonomy
Acetoacetate decarboxylaseAAD; ADC; EC 4.1.1.4Clostridium acetobutylicum ATCC 824
3-hydroxybutyryl-CoA dehydrogenaseEC 1.1.1.157; Beta-hydroxybutyryl-CoA dehydrogenase; BHBDClostridium acetobutylicum ATCC 824
Phosphate acetyltransferaseEC 2.3.1.8; PhosphotransacetylaseClostridium acetobutylicum ATCC 824
Acyl-CoA dehydrogenase, short-chain specificEC 1.3.8.1; Butyryl-CoA dehydrogenase; SCADClostridium acetobutylicum ATCC 824
Acetate kinaseEC 2.7.2.1; AcetokinaseClostridium acetobutylicum ATCC 824
Short-chain-enoyl-CoA hydrataseEC 4.2.1.150; 3-hydroxybutyryl-CoA dehydratase; CrotonaseClostridium acetobutylicum ATCC 824
Acetyl-CoA acetyltransferaseEC 2.3.1.9; Acetoacetyl-CoA thiolaseClostridium acetobutylicum ATCC 824
Butyrate--acetoacetate CoA-transferase subunit BCoat B; EC 2.8.3.9; Acetoacetyl-CoA:acetate/butyrate CoA-transferase subunit BClostridium acetobutylicum ATCC 824
Butyrate--acetoacetate CoA-transferase subunit ACoat A; EC 2.8.3.9; Acetoacetyl-CoA:acetate/butyrate:CoA transferase subunit AClostridium acetobutylicum ATCC 824
NADPH-dependent butanol dehydrogenaseBDH; EC 1.1.1.-Clostridium saccharobutylicum
Aldehyde-alcohol dehydrogenaseAADClostridium acetobutylicum ATCC 824
Phosphate butyryltransferaseEC 2.3.1.19; PhosphotransbutyrylaseClostridium acetobutylicum ATCC 824
NADH-dependent butanol dehydrogenase AEC 1.1.1.-; BDH IClostridium acetobutylicum ATCC 824
NADH-dependent butanol dehydrogenase BEC 1.1.1.-; BDH IIClostridium acetobutylicum ATCC 824
Butyrate kinase 1BK 1; BKI; EC 2.7.2.7Clostridium acetobutylicum ATCC 824
3-hydroxybutyryl-CoA dehydrogenase Clostridium beijerinckii
Aldehyde-alcohol dehydrogenaseClostridium acetobutylicum
Pyruvate:ferredoxin oxidoreductaseClostridium acetobutylicum ATCC 824

Compounds (43)

CompoundDescription
1-propanolA colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.
hydronium ion
n-Butyrate
Thiamine PyrophosphateThe coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.
NADH
Ammonium
MercuryA silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
EthanolA clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
potassiumAn element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
SodiumA member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
iodoacetamideAn alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
benzoylacetone
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
1,10-phenanthrolineRN given refers to parent cpd; inhibits Zn-dependent metalloproteinases
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
acetaldehydeA colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetoneA colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.
butyraldehyde
1-butanolA four carbon linear hydrocarbon that has a hydroxy group at position 1.
acetyl phosphate
Sodium Dodecyl SulfateAn anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.
acetopyruvate
4-ChloromercuribenzenesulfonateA cytotoxic sulfhydryl reagent that inhibits several subcellular metabolic systems and is used as a tool in cellular physiology.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
methylethyl ketonesolvent; colorless synthetic resins, smokeless powders; may be irritating to eyes, mucous membranes; may be toxic in high concentrations; structure
acetoacetate
hydrogen cyanideHydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.
Coenzyme A
sapropterinRN given refers to parent cpd; co-factor required for catalytic activity of nitric oxide synthases
acetylacetone
acetoacetyl CoA
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
4,7-phenanthroline