Page last updated: 2024-10-06

superpathway of N-acetylneuraminate degradation

Proteins (39)

ProteinSynonymsTaxonomy
Fructose-bisphosphate aldolase class 2FBP aldolase; FBPA; EC 4.1.2.13; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class IIEscherichia coli K-12
Fructose-bisphosphate aldolase class 1EC 4.1.2.13; Fructose-bisphosphate aldolase class I; FBP aldolaseEscherichia coli K-12
Phosphate acetyltransferaseEC 2.3.1.8; PhosphotransacetylaseEscherichia coli K-12
Pyruvate kinase IEC 2.7.1.40; PK-1Escherichia coli K-12
Pyruvate kinase IIEC 2.7.1.40; PK-2Escherichia coli K-12
Alkaline phosphataseAPase; EC 3.1.3.1Escherichia coli K-12
Phosphocarrier protein HPrHistidine-containing proteinEscherichia coli K-12
Triosephosphate isomeraseTIM; TPI; EC 5.3.1.1; Triose-phosphate isomeraseEscherichia coli K-12
Acetate kinaseEC 2.7.2.1; AcetokinaseEscherichia coli K-12
N-acetylneuraminate lyaseNAL; Neu5Ac lyase; EC 4.1.3.3; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NALase; Sialate lyase; Sialic acid aldolase; Sialic acid lyaseEscherichia coli K-12
EnolaseEC 4.2.1.11; 2-phospho-D-glycerate hydro-lyase; 2-phosphoglycerate dehydrataseEscherichia coli K-12
N-acetylneuraminate lyaseNAL; Neu5Ac lyase; EC 4.1.3.3; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyaseClostridium perfringens str. 13
Glucosamine-6-phosphate deaminaseEC 3.5.99.6; GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomeraseStreptococcus sanguinis SK36
Glucosamine-6-phosphate deaminaseEC 3.5.99.6; GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomeraseEscherichia coli K-12
N-acetylglucosamine-6-phosphate deacetylaseGlcNAc 6-P deacetylase; EC 3.5.1.25Escherichia coli K-12
N-acetylmannosamine kinaseEC 2.7.1.60; ManNAc kinase; N-acetyl-D-mannosamine kinaseEscherichia coli K-12
Alcohol dehydrogenase, propanol-preferringEC 1.1.1.1Escherichia coli K-12
ATP-dependent 6-phosphofructokinase isozyme 2ATP-PFK 2; Phosphofructokinase 2; EC 2.7.1.11; 6-phosphofructokinase isozyme II; Phosphohexokinase 2Escherichia coli K-12
ATP-dependent 6-phosphofructokinase isozyme 1ATP-PFK 1; Phosphofructokinase 1; EC 2.7.1.11; 6-phosphofructokinase isozyme I; Phosphohexokinase 1Escherichia coli K-12
Putative N-acetylmannosamine-6-phosphate 2-epimeraseEC 5.1.3.9; ManNAc-6-P epimeraseEscherichia coli K-12
Putative N-acetylmannosamine-6-phosphate 2-epimeraseEC 5.1.3.9; ManNAc-6-P epimeraseClostridium perfringens str. 13
Acetaldehyde dehydrogenaseEC 1.2.1.10; Acetaldehyde dehydrogenase [acetylating]Escherichia coli K-12
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseBPG-independent PGAM; Phosphoglyceromutase; iPGM; EC 5.4.2.12Escherichia coli K-12
Fructose-1,6-bisphosphatase class 1FBPase class 1; EC 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1Escherichia coli K-12
Formate acetyltransferase 1EC 2.3.1.54; Pyruvate formate-lyase 1Escherichia coli K-12
Phosphoglycerate kinaseEC 2.7.2.3Escherichia coli K-12
Glyceraldehyde-3-phosphate dehydrogenase AGAPDH-A; EC 1.2.1.12; NAD-dependent glyceraldehyde-3-phosphate dehydrogenaseEscherichia coli K-12
Fructose-1,6-bisphosphatase 1 class 2FBPase 1 class 2; EC 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 class 2Escherichia coli K-12
Aldehyde-alcohol dehydrogenaseEscherichia coli K-12
Nitrogen regulatory protein P-II 1Escherichia coli K-12
Fructose-1,6-bisphosphatase 2 class 2FBPase 2 class 2; EC 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 class 2Escherichia coli K-12
Pyridoxal phosphate phosphatase YbhAPLP phosphatase; EC 3.1.3.74Escherichia coli K-12
Phosphoenolpyruvate synthasePEP synthase; EC 2.7.9.2; Pyruvate, water dikinaseEscherichia coli K-12
Formate-dependent phosphoribosylglycinamide formyltransferase5'-phosphoribosylglycinamide transformylase 2; Formate-dependent GAR transformylase; 2.1.2.-; GAR transformylase 2; GART 2; Non-folate glycinamide ribonucleotide transformylase; Phosphoribosylglycinamide formyltransferase 2Escherichia coli K-12
PFL-like enzyme TdcEKeto-acid formate acetyltransferase; Keto-acid formate-lyase; Ketobutyrate formate-lyase; KFL; 2.3.1.-; Pyruvate formate-lyase; PFL; 2.3.1.54Escherichia coli K-12
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseBPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM; EC 5.4.2.11Escherichia coli K-12
Ethanolamine utilization protein EutDEscherichia coli K-12
N-acetylneuraminate lyase, putative Streptococcus sanguinis SK36
N-acetylglucosamine-6-phosphate deacetylase, putative Streptococcus sanguinis SK36

Compounds (52)

CompoundDescription
hydronium ion
NADH
Ammonium
CopperA heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
fluoridesInorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.
LithiumAn element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.
serum p-componentclose relation to C reactive protein; may be ovosomucoid
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
fomepizoleA pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
Orthophosphate
guaiacolAn agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)
potassium chlorideA white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
EthanolA clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
potassiumAn element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
NickelA trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
succinyl-coenzyme A
pyrazolestructure in Merck Index, 9th ed, #7744
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
alpha-Ketoglutarate
OxaloacetateAn anionic form of oxaloacetic acid.
acetaldehydeA colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
StreptokinaseStreptococcal fibrinolysin An enzyme produced by hemolytic streptococci. It hydrolyzes amide linkages and serves as an activator of plasminogen. It is used in thrombolytic therapy and is used also in mixtures with streptodornase (STREPTODORNASE AND STREPTOKINASE). EC 3.4.-.
benzaldehydeRN given refers to parent cpd; structure
formate
diethyl pyrocarbonatePreservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.
acetyl phosphate
dithiothreitolA reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
glucosamine 6-phosphateRN given refers to parent cpd
Edetic AcidA chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
fructose-1,6-diphosphateRN refers to (D)-isomer
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
vanadatesOxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.
dihydroxyacetoneA ketotriose compound. Its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage. It is readily phosphorylated to dihydroxyacetone phosphate by triokinase in erythrocytes. In combination with naphthoquinones it acts as a sunscreening agent.
bromosuccinimideA brominating agent that replaces hydrogen atoms in benzylic or allylic positions. It is used in the oxidation of secondary alcohols to ketones and in controlled low-energy brominations. (From Miall's Dictionary of Chemistry, 5th ed; Hawley's Condensed Chemical Dictionary, 12th ed,).
glyceraldehydeAn aldotriose containing the propionaldehyde structure with hydroxy groups at the 2- and 3-positions. It is involved in the formation of ADVANCED GLYCOSYLATION END PRODUCTS.
ticrynafenA novel diuretic with uricosuric action. It has been proposed as an antihypertensive agent.
Coenzyme A
sapropterinRN given refers to parent cpd; co-factor required for catalytic activity of nitric oxide synthases
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
glycerate 1,3-biphosphate
2-acetamido-2-deoxy-mannose-6-phosphatestructure in first source
2-deoxy-2-aminoglucitol-6-phosphateinhibits glucosamine 6-phosphate deaminase