Page last updated: 2024-10-06

superpathway of 5-aminoimidazole ribonucleotide biosynthesis

Proteins (6)

ProteinSynonymsTaxonomy
Phosphoribosylglycinamide formyltransferaseEC 2.1.2.2; 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GARTEscherichia coli K-12
Phosphoribosylformylglycinamidine synthaseFGAM synthase; FGAMS; EC 6.3.5.3; Formylglycinamide ribonucleotide amidotransferase; FGAR amidotransferase; FGAR-ATEscherichia coli K-12
AmidophosphoribosyltransferaseATase; EC 2.4.2.14; Glutamine phosphoribosylpyrophosphate amidotransferase; GPATaseEscherichia coli K-12
Phosphoribosylformylglycinamidine cyclo-ligaseEC 6.3.3.1; AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetaseEscherichia coli K-12
Phosphoribosylamine--glycine ligaseEC 6.3.4.13; GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetaseEscherichia coli K-12
Formate-dependent phosphoribosylglycinamide formyltransferase5'-phosphoribosylglycinamide transformylase 2; Formate-dependent GAR transformylase; 2.1.2.-; GAR transformylase 2; GART 2; Non-folate glycinamide ribonucleotide transformylase; Phosphoribosylglycinamide formyltransferase 2Escherichia coli K-12

Compounds (19)

CompoundDescription
diphosphoric acid
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
potassiumAn element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
glycineamide ribonucleotidestructure
iodoacetamideAn alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
formate
glutamate
4-mercuribenzoate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer
xanthosine monophosphate
2-amino-4-oxo-5-chloropentanoateinhibitor of asparagine synthetase; structure