| Protein | Synonyms | Taxonomy |
|---|
| Sodium/calcium exchanger 1 | Na(+)/Ca(2+)-exchange protein 1; Solute carrier family 8 member 1 | Homo sapiens (human) |
| cAMP-dependent protein kinase type I-alpha regulatory subunit | Tissue-specific extinguisher 1; TSE1 | Homo sapiens (human) |
| Protein disulfide-isomerase A4 | EC 5.3.4.1; Endoplasmic reticulum resident protein 70; ER protein 70; ERp70; Endoplasmic reticulum resident protein 72; ER protein 72; ERp-72; ERp72 | Homo sapiens (human) |
| Cytochrome P450 1A2 | EC 1.14.14.1; CYPIA2; Cholesterol 25-hydroxylase; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152 | Homo sapiens (human) |
| Muscarinic acetylcholine receptor M2 | | Homo sapiens (human) |
| Cytochrome P450 3A4 | EC 1.14.14.1; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; 1.14.14.56; Albendazole monooxygenase (sulfoxide-forming); 1.14.14.73; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; Cytochrome | Homo sapiens (human) |
| Cytochrome P450 2C9 | EC 1.14.14.1; (R)-limonene 6-monooxygenase; 1.14.14.53; (S)-limonene 6-monooxygenase; 1.14.14.51; (S)-limonene 7-monooxygenase; 1.14.14.52; CYPIIC9; Cholesterol 25-hydroxylase; Cytochrome P-450MP; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P45 | Homo sapiens (human) |
| UDP-glucuronosyltransferase 1-6 | UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; EC 2.4.1.17; Phenol-metabolizing UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1-F; UGT-1F; UGT1F; UDP-glucuronosyltransferase 1A6 | Homo sapiens (human) |
| Cytochrome P450 2C19 | EC 1.14.14.1; (R)-limonene 6-monooxygenase; 1.14.14.53; (S)-limonene 6-monooxygenase; 1.14.14.51; (S)-limonene 7-monooxygenase; 1.14.14.52; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Fenbendazole monooxygenase (4'-hydroxylating); 1.14. | Homo sapiens (human) |
| G protein-activated inward rectifier potassium channel 4 | GIRK-4; Cardiac inward rectifier; CIR; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; IRK-4; KATP-1; Potassium channel, inwardly rectifying subfamily J member 5 | Homo sapiens (human) |
| Potassium voltage-gated channel subfamily H member 2 | Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1 | Homo sapiens (human) |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2 | Homo sapiens (human) |
| Sodium channel protein type 5 subunit alpha | Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5; hH1 | Homo sapiens (human) |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | SERCA2; SR Ca(2+)-ATPase 2; EC 7.2.2.10; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase | Homo sapiens (human) |
| ATP-sensitive inward rectifier potassium channel 8 | Inward rectifier K(+) channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1 | Homo sapiens (human) |
| Protein disulfide-isomerase A2 | EC 5.3.4.1; Pancreas-specific protein disulfide isomerase; PDIp | Homo sapiens (human) |
| Voltage-dependent L-type calcium channel subunit beta-1 | CAB1; Calcium channel voltage-dependent subunit beta 1 | Homo sapiens (human) |
| Voltage-dependent T-type calcium channel subunit alpha-1G | Cav3.1c; NBR13; Voltage-gated calcium channel subunit alpha Cav3.1 | Homo sapiens (human) |
| Voltage-dependent T-type calcium channel subunit alpha-1H | Low-voltage-activated calcium channel alpha1 3.2 subunit; Voltage-gated calcium channel subunit alpha Cav3.2 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit beta-1 | Sodium/potassium-dependent ATPase subunit beta-1 | Homo sapiens (human) |
| Cytochrome P450 2E1 | EC 1.14.14.1; 4-nitrophenol 2-hydroxylase; 1.14.13.n7; CYPIIE1; Cytochrome P450-J | Homo sapiens (human) |
| Beta-1 adrenergic receptor | Beta-1 adrenoreceptor; Beta-1 adrenoceptor | Homo sapiens (human) |
| NAD | EC 1.6.5.2; Azoreductase; DT-diaphorase; DTD; Menadione reductase; NAD(P)H:quinone oxidoreductase 1; Phylloquinone reductase; Quinone reductase 1; QR1 | Homo sapiens (human) |
| cAMP-dependent protein kinase catalytic subunit alpha | PKA C-alpha; EC 2.7.11.11 | Homo sapiens (human) |
| Potassium voltage-gated channel subfamily A member 5 | HPCN1; Voltage-gated potassium channel HK2; Voltage-gated potassium channel subunit Kv1.5 | Homo sapiens (human) |
| Tropomyosin alpha-1 chain | Alpha-tropomyosin; Tropomyosin-1 | Homo sapiens (human) |
| ATP-binding cassette sub-family C member 9 | Sulfonylurea receptor 2 | Homo sapiens (human) |
| Epoxide hydrolase 1 | EC 3.3.2.9; Epoxide hydratase; Microsomal epoxide hydrolase; mEH | Homo sapiens (human) |
| Catechol O-methyltransferase | EC 2.1.1.6 | Homo sapiens (human) |
| Peptidyl-prolyl cis-trans isomerase B | PPIase B; EC 5.2.1.8; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP | Homo sapiens (human) |
| ATP-binding cassette sub-family C member 8 | Sulfonylurea receptor 1 | Homo sapiens (human) |
| Ryanodine receptor 2 | RYR-2; RyR2; hRYR-2; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor | Homo sapiens (human) |
| Inward rectifier potassium channel 4 | HIRK2; HRK1; Hippocampal inward rectifier; HIR; Inward rectifier K(+) channel Kir2.3; IRK-3; Potassium channel, inwardly rectifying subfamily J member 4 | Homo sapiens (human) |
| Kv channel-interacting protein 2 | KChIP2; A-type potassium channel modulatory protein 2; Cardiac voltage-gated potassium channel modulatory subunit; Potassium channel-interacting protein 2 | Homo sapiens (human) |
| Endoplasmic reticulum chaperone BiP | EC 3.6.4.10; 78 kDa glucose-regulated protein; GRP-78; Binding-immunoglobulin protein; BiP; Heat shock protein 70 family protein 5; HSP70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit alpha-4 | Na(+)/K(+) ATPase alpha-4 subunit; EC 7.2.2.13; Sodium pump subunit alpha-4 | Homo sapiens (human) |
| Voltage-dependent calcium channel subunit alpha-2/delta-2 | Voltage-gated calcium channel subunit alpha-2/delta-2 | Homo sapiens (human) |
| UDP-glucuronosyltransferase 1A9 | UGT1A9; EC 2.4.1.17; UDP-glucuronosyltransferase 1-9; UDPGT 1-9; UGT1*9; UGT1-09; UGT1.9; UDP-glucuronosyltransferase 1-I; UGT-1I; UGT1I; lugP4 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Na(+)/K(+) ATPase alpha-1 subunit; EC 7.2.2.13; Sodium pump subunit alpha-1 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit alpha-3 | Na(+)/K(+) ATPase alpha-3 subunit; EC 7.2.2.13; Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit beta-2 | Adhesion molecule in glia; AMOG; Sodium/potassium-dependent ATPase subunit beta-2 | Homo sapiens (human) |
| Potassium voltage-gated channel subfamily E member 1 | Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel | Homo sapiens (human) |
| UDP-glucuronosyltransferase 1A1 | UGT1A1; EC 2.4.1.17; Bilirubin-specific UDPGT isozyme 1; hUG-BR1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UDP-glucuronosyltransferase 1A isoform 1 | Homo sapiens (human) |
| G protein-activated inward rectifier potassium channel 1 | GIRK-1; Inward rectifier K(+) channel Kir3.1; Potassium channel, inwardly rectifying subfamily J member 3 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit alpha-2 | Na(+)/K(+) ATPase alpha-2 subunit; EC 7.2.2.13; Sodium pump subunit alpha-2 | Homo sapiens (human) |
| Potassium voltage-gated channel subfamily KQT member 1 | IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit beta-3 | Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit gamma | Na(+)/K(+) ATPase subunit gamma; FXYD domain-containing ion transport regulator 2; Sodium pump gamma chain | Homo sapiens (human) |
| Inward rectifier potassium channel 2 | Cardiac inward rectifier potassium channel; Inward rectifier K(+) channel Kir2.1; IRK-1; hIRK1; Potassium channel, inwardly rectifying subfamily J member 2 | Homo sapiens (human) |
| ATP-sensitive inward rectifier potassium channel 11 | IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11 | Homo sapiens (human) |
| Protein disulfide-isomerase A6 | EC 5.3.4.1; Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7 | Homo sapiens (human) |
| Potassium voltage-gated channel subfamily D member 3 | Voltage-gated potassium channel subunit Kv4.3 | Homo sapiens (human) |
| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | | Homo sapiens (human) |
| UDP-glucuronosyltransferase 1A4 | UGT1A4; EC 2.4.1.17; Bilirubin-specific UDPGT isozyme 2; hUG-BR2; UDP-glucuronosyltransferase 1-4; UDPGT 1-4; UGT1*4; UGT1-04; UGT1.4; UDP-glucuronosyltransferase 1-D; UGT-1D; UGT1D | Homo sapiens (human) |
| Cardiac phospholamban | PLB | Homo sapiens (human) |
| Beta-2-syntrophin | 59 kDa dystrophin-associated protein A1 basic component 2; Syntrophin-3; SNT3; Syntrophin-like; SNTL | Homo sapiens (human) |
| Endoplasmic reticulum resident protein 29 | ERp29; Endoplasmic reticulum resident protein 28; ERp28; Endoplasmic reticulum resident protein 31; ERp31 | Homo sapiens (human) |
| Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase | EC 2.4.1.256; Alpha-1,2-glucosyltransferase ALG10-A; Alpha-2-glucosyltransferase ALG10-B; Asparagine-linked glycosylation protein 10 homolog B; Potassium channel regulator 1 | Homo sapiens (human) |
| Potassium channel subfamily K member 1 | Inward rectifying potassium channel protein TWIK-1; Potassium channel K2P1; Potassium channel KCNO1 | Homo sapiens (human) |
| Tropomyosin beta chain | Beta-tropomyosin; Tropomyosin-2 | Homo sapiens (human) |
| Disks large homolog 1 | Synapse-associated protein 97; SAP-97; SAP97; hDlg | Homo sapiens (human) |
| Alpha-1-syntrophin | 59 kDa dystrophin-associated protein A1 acidic component 1; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; TACIP1; Syntrophin-1 | Homo sapiens (human) |
| Beta-1-syntrophin | 59 kDa dystrophin-associated protein A1 basic component 1; DAPA1B; BSYN2; Syntrophin-2; Tax interaction protein 43; TIP-43 | Homo sapiens (human) |
| Stromal cell-derived factor 2-like protein 1 | SDF2-like protein 1; PWP1-interacting protein 8 | Homo sapiens (human) |
| DnaJ homolog subfamily B member 11 | APOBEC1-binding protein 2; ABBP-2; DnaJ protein homolog 9; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; Endoplasmic reticulum DNA J domain-containing protein 3; ER-resident protein ERdj3; ERdj3; ERj3p; HEDJ; Human DnaJ protein 9; hDj-9; PWP1-inte | Homo sapiens (human) |
| Potassium voltage-gated channel subfamily E member 2 | MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1 | Homo sapiens (human) |
| HYOU1 protein | | Homo sapiens (human) |
| Endoplasmin | | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit beta | | Homo sapiens (human) |
| Compound | Description |
|---|
| hydronium ion | |
| Orthophosphate | |
| phenytoin | An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| uridine diphosphate | A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety. |
| potassium | An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE. |
| Sodium | A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| 5-phenyl-5-(4-hydroxyphenyl)hydantoin glucuronide | metabolite of phenytoin |
| 5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin | metabolite of phenytoin; RN given refers to cpd without isomeric designation |
| 5-(3,4-dihydroxyphenyl)-5-phenylhydantoin | metabolite of phenytoin |
| uridine diphosphate glucuronic acid | A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones. |
| hydroxyphenytoin | main metabolite of diphenylhydantoin; reduces Na(+) inhibition at high Na:K ratios; RN given refers to cpd without isomeric designation; structure |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| creolin | from refined coal tar oils |