Page last updated: 2024-10-06

superpathway of tetrahydrofolate biosynthesis

Proteins (10)

ProteinSynonymsTaxonomy
Aminodeoxychorismate synthase, chloroplasticADC synthase; EC 2.6.1.85; P-aminobenzoic acid synthase; PABA synthase; Para-aminobenzoate synthaseSolanum lycopersicum (tomato)
Aminodeoxychorismate synthase, chloroplasticADC synthase; EC 2.6.1.85; P-aminobenzoic acid synthase; PABA synthase; Para-aminobenzoate synthase; Protein EMBRYO DEFFECTIVE 1997Arabidopsis thaliana (thale cress)
GTP cyclohydrolase 1EC 3.5.4.16; GTP cyclohydrolase IArabidopsis thaliana (thale cress)
D-amino-acid transaminase, chloroplasticEC 2.6.1.21; EC 4.1.3.38; Aminodeoxychorismate lyase; AtADCL; Branched-chain-amino-acid aminotransferase-like protein 3Arabidopsis thaliana (thale cress)
Dihydroneopterin aldolase 1DHNA1; EC 4.1.2.25; 7,8-dihydroneopterin aldolase; AtFolB1Arabidopsis thaliana (thale cress)
Bifunctional dihydrofolate reductase-thymidylate synthaseDHFR-TSGlycine max (soybean)
Folate synthesis bifunctional proteinArabidopsis thaliana (thale cress)
Nudix hydrolase 1AtNUDT1; 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTP diphosphatase; 8-oxo-dGTPase; 3.6.1.55; Dihydroneopterin triphosphate diphosphatase; 3.6.1.67; Dihydroneopterin triphosphate pyrophosphohydrolase; DHNTP pyrophosphohydrolase; NADH pyrophosphatasArabidopsis thaliana (thale cress)
Bifunctional dihydrofolate reductase-thymidylate synthasePisum sativum (garden pea)
Dihydrofolate synthetase /folylpolyglutamate synthetaseArabidopsis thaliana (thale cress)

Compounds (24)

CompoundDescription
diphosphoric acid
hydronium ion
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
6-hydroxymethyl-7,8-dihydropterin
7,8-dihydroneopterinan antioxidant
dihydrofolateRN given refers to (L)-isomer
dihydroneopterin triphosphate
dihydroneopterin triphosphate
guanosine triphosphateGuanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.
2-amino-4-hydroxy-6-pyrophosphoryl-methylpteridine
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
formic acidRN given refers to parent cpd
4-aminobenzoic acidAn aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.
Edetic AcidA chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer
glycolaldehydestructure