Page last updated: 2024-10-06

Iron uptake and transport

Proteins (28)

ProteinSynonymsTaxonomy
Neutrophil gelatinase-associated lipocalinNGAL; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin; p25Homo sapiens (human)
Broad substrate specificity ATP-binding cassette transporter ABCG2EC 7.6.2.2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporterHomo sapiens (human)
SerotransferrinTransferrin; Beta-1 metal-binding globulin; SiderophilinHomo sapiens (human)
Cullin-1CUL-1Homo sapiens (human)
NEDD8Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; NEDD-8; Ubiquitin-like protein Nedd8Homo sapiens (human)
Natural resistance-associated macrophage protein 2NRAMP 2; Divalent cation transporter 1; Divalent metal transporter 1; DMT-1; Solute carrier family 11 member 2Homo sapiens (human)
Mucolipin-1ML1; MG-2; Mucolipidin; Transient receptor potential channel mucolipin 1; TRPML1Homo sapiens (human)
Proton-coupled folate transporterG21; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1Homo sapiens (human)
V-type proton ATPase subunit S1V-ATPase subunit S1; Protein XAP-3; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; Vacuolar proton pump subunit S1Homo sapiens (human)
Transferrin receptor protein 1TR; TfR; TfR1; Trfr; T9; p90Homo sapiens (human)
Cytoplasmic aconitate hydrataseAconitase; EC 4.2.1.3; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1Homo sapiens (human)
Iron-responsive element-binding protein 2IRE-BP 2; Iron regulatory protein 2; IRP2Homo sapiens (human)
Solute carrier family 40 member 1Ferroportin-1; Iron-regulated transporter 1Homo sapiens (human)
S-phase kinase-associated protein 1Cyclin-A/CDK2-associated protein p19; p19A; Organ of Corti protein 2; OCP-2; Organ of Corti protein II; OCP-II; RNA polymerase II elongation factor-like protein; SIII; Transcription elongation factor B polypeptide 1-like; p19skp1Homo sapiens (human)
Ferritin, mitochondrialEC 1.16.3.1Homo sapiens (human)
Transferrin receptor protein 2TfR2Homo sapiens (human)
CeruloplasminEC 1.16.3.1; FerroxidaseHomo sapiens (human)
Cytochrome b reductase 1EC 1.-.-.-; Duodenal cytochrome b; Ferric-chelate reductase 3Homo sapiens (human)
Hereditary hemochromatosis proteinHLA-HHomo sapiens (human)
F-box/LRR-repeat protein 5F-box and leucine-rich repeat protein 5; F-box protein FBL4/FBL5; p45SKP2-like proteinHomo sapiens (human)
Glutaredoxin-3PKC-interacting cousin of thioredoxin; PICOT; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2Homo sapiens (human)
V-type proton ATPase subunit FV-ATPase subunit F; V-ATPase 14 kDa subunit; Vacuolar proton pump subunit FHomo sapiens (human)
Cullin-associated NEDD8-dissociated protein 1Cullin-associated and neddylation-dissociated protein 1; TBP-interacting protein of 120 kDa A; TBP-interacting protein 120A; p120 CAND1Homo sapiens (human)
Solute carrier family 22 member 1724p3 receptor; 24p3R; Brain-type organic cation transporter; Lipocalin-2 receptor; Neutrophil gelatinase-associated lipocalin receptor; NgalRHomo sapiens (human)
V-type proton ATPase 21 kDa proteolipid subunitV-ATPase 21 kDa proteolipid subunit; Vacuolar proton pump 21 kDa proteolipid subunit; hATPLHomo sapiens (human)
HephaestinEC 1.-.-.-Homo sapiens (human)
V-type proton ATPase subunit HV-ATPase subunit H; Nef-binding protein 1; NBP1; Protein VMA13 homolog; V-ATPase 50/57 kDa subunits; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFDHomo sapiens (human)
V-type proton ATPase subunit DV-ATPase subunit D; V-ATPase 28 kDa accessory protein; Vacuolar proton pump subunit DHomo sapiens (human)

Compounds (17)

CompoundDescription
hydronium ion
CopperA heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
CopperA heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
carbon monoxideCarbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
IronA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
citric acid, anhydrous
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
2,5-dihydroxybenzoic acidRN given refers to parent cpd; a oxidative product of saligenin
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Biliverdine1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone. Biosynthesized from hemoglobin as a precursor of bilirubin. Occurs in the bile of AMPHIBIANS and of birds, but not in normal human bile or serum.
hemeThe color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.