| Protein | Synonyms | Taxonomy |
|---|
| Squalene monooxygenase | EC 1.14.14.17; Squalene epoxidase; SE | Homo sapiens (human) |
| Geranylgeranyl pyrophosphate synthase | GGPP synthase; GGPPSase; EC 2.5.1.-; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Farnesyltranstransferase; 2.5.1.29; Geranylgeranyl diphosphate synthase; Geranyltranstransferase; 2.5.1.10 | Homo sapiens (human) |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMG-CoA reductase; EC 1.1.1.34 | Homo sapiens (human) |
| Farnesyl pyrophosphate synthase | FPP synthase; FPS; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Geranyltranstransferase | Homo sapiens (human) |
| Squalene synthase | SQS; SS; EC 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase 1 | Homo sapiens (human) |
| Lanosterol synthase | EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSC | Homo sapiens (human) |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | EC 5.3.3.5; Cholestenol Delta-isomerase; Delta(8)-Delta(7) sterol isomerase; D8-D7 sterol isomerase; Emopamil-binding protein | Homo sapiens (human) |
| 7-dehydrocholesterol reductase | 7-DHC reductase; EC 1.3.1.21; Delta7-sterol reductase; Sterol Delta(7)-reductase; Sterol reductase SR-2 | Homo sapiens (human) |
| Diphosphomevalonate decarboxylase | EC 4.1.1.33; Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase | Homo sapiens (human) |
| Hydroxymethylglutaryl-CoA synthase, mitochondrial | HMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase | Homo sapiens (human) |
| Hydroxymethylglutaryl-CoA synthase, cytoplasmic | HMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase | Homo sapiens (human) |
| Acetyl-CoA acetyltransferase, mitochondrial | EC 2.3.1.9; Acetoacetyl-CoA thiolase; T2 | Homo sapiens (human) |
| 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 | 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; 1.1.1.270; Dihydrotestosterone oxidoreductase; 1.1.1.210; Estradiol 17-beta-dehydrogenase 7; 1.1.1.62; Short chain dehydrogenase/reductase family 37C member 1 | Homo sapiens (human) |
| Lathosterol oxidase | EC 1.14.19.20; C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase | Homo sapiens (human) |
| Delta(14)-sterol reductase LBR | Delta-14-SR; EC 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Integral nuclear envelope inner membrane protein; LMN2R; Lamin-B receptor; Sterol C14-reductase | Homo sapiens (human) |
| Isopentenyl-diphosphate Delta-isomerase 1 | EC 5.3.3.2; Isopentenyl pyrophosphate isomerase 1; IPP isomerase 1; IPPI1 | Homo sapiens (human) |
| Isopentenyl-diphosphate delta-isomerase 2 | EC 5.3.3.2; Isopentenyl pyrophosphate isomerase 2; IPP isomerase 2; IPPI2 | Homo sapiens (human) |
| Acetyl-CoA acetyltransferase, cytosolic | EC 2.3.1.9; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase | Homo sapiens (human) |
| Mevalonate kinase | MK; EC 2.7.1.36 | Homo sapiens (human) |
| Phosphomevalonate kinase | PMKase; hPMK; EC 2.7.4.2 | Homo sapiens (human) |
| Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating | EC 1.1.1.170; Protein H105e3 | Homo sapiens (human) |
| Compound | Description |
|---|
| diphosphoric acid | |
| hydronium ion | |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| Orthophosphate | |
| Cholesterol | The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. |
| squalene | A natural 30-carbon triterpene. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| potassium | An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE. |
| Magnesium | A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION. |
| Sodium | A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| zymostenol | RN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not available 9/88 |
| Selenite | |
| 32-hydroxy-24,25-dihydrolanosterol | |
| lanosten-3-ol-32-al | RN given refers to (3beta)-isomer |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| isopentenyl pyrophosphate | substrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells |
| farnesyl pyrophosphate | a sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation |
| 4,4-dimethylcholesta-8,14-dien-3-ol | RN refers to (3beta,5alpha)-isomer; a meiosis-activating sterol |
| geranyl diphosphate | structure in first source |
| formate | |
| 7-dehydrocholesterol | RN given refers to (3beta)-isomer; structure; main provitamin in skin that is converted by sunlight to cholecalciferol (vitamin D3) |
| desmosterol | An intermediate in the synthesis of cholesterol. |
| 24-dehydroprovitamin D3 | |
| 24,25-dihydrolanosterol | |
| 4,4-dimethylcholesta-8,14,24-trienol | a meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer |
| Mevalonate | |
| 2,3-oxidosqualene | an oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer |
| cholesta-7,24-dien-3-ol | minor metabolite of in vitro incubation of mevalonic acid with yeast; structure; RN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not avail 10/89 |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| 4-methylcholest-8-en-3-ol, (3beta,4alpha,5alpha)-isomer | |
| lathosterol | RN given refers to (3beta,5alpha)-isomer |
| tellurate | |
| 4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol | RN given refers to (3beta,5alpha)-isomer |
| 32-oxolanosterol | found in mevalonate-treated cell cultures |
| 32-hydroxylanosterol | found in mevalonate-treated cell cultures |
| lanosterol | A triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS. |
| Coenzyme A | |
| Ro 48-8071 | a cholesterol synthesis inhibitor; structure in first source |
| acetoacetyl CoA | |
| Acetyl Coenzyme A | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| Flavin-Adenine Dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |
| zymosterol | a 4,14-desmethyl intermediate between LANOSTEROL and CHOLESTEROL |
| BM 15766 | 7-dehydrocholesterol reductase antagonist |