Pathways > Naloxone Action Pathway
Page last updated: 2024-10-06

Naloxone Action Pathway

Proteins (31)

ProteinSynonymsTaxonomy
Sodium channel subunit beta-1Homo sapiens (human)
5-hydroxytryptamine receptor 1A5-HT-1A; 5-HT1A; G-21; Serotonin receptor 1AHomo sapiens (human)
Neuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
D(1A) dopamine receptorDopamine D1 receptorHomo sapiens (human)
Sodium-dependent serotonin transporterSERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4Homo sapiens (human)
Alpha-1A adrenergic receptorAlpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1cHomo sapiens (human)
Mu-type opioid receptorM-OR-1; MOR-1; Mu opiate receptor; Mu opioid receptor; MOP; hMOPHomo sapiens (human)
Neuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
Voltage-dependent L-type calcium channel subunit beta-1CAB1; Calcium channel voltage-dependent subunit beta 1Homo sapiens (human)
Voltage-dependent P/Q-type calcium channel subunit alpha-1ABrain calcium channel I; BI; Calcium channel, L type, alpha-1 polypeptide isoform 4; Voltage-gated calcium channel subunit alpha Cav2.1Homo sapiens (human)
Sodium/potassium-transporting ATPase subunit beta-1Sodium/potassium-dependent ATPase subunit beta-1Homo sapiens (human)
Sodium-dependent noradrenaline transporter Norepinephrine transporter; NET; Solute carrier family 6 member 2Homo sapiens (human)
Sodium-dependent dopamine transporter DA transporter; DAT; Solute carrier family 6 member 3Homo sapiens (human)
Glutamate receptor ionotropic, NMDA 1GluN1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1Homo sapiens (human)
Glutamate receptor ionotropic, NMDA 2AGluN2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2AHomo sapiens (human)
Potassium voltage-gated channel subfamily D member 2Voltage-gated potassium channel subunit Kv4.2Homo sapiens (human)
Sodium channel protein type 10 subunit alphaPeripheral nerve sodium channel 3; PN3; hPN3; Sodium channel protein type X subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.8Homo sapiens (human)
Neuroendocrine convertase 2NEC 2; EC 3.4.21.94; KEX2-like endoprotease 2; Prohormone convertase 2; Proprotein convertase 2; PC2Homo sapiens (human)
Kv channel-interacting protein 2KChIP2; A-type potassium channel modulatory protein 2; Cardiac voltage-gated potassium channel modulatory subunit; Potassium channel-interacting protein 2Homo sapiens (human)
Sodium/potassium-transporting ATPase subunit alpha-4Na(+)/K(+) ATPase alpha-4 subunit; EC 7.2.2.13; Sodium pump subunit alpha-4Homo sapiens (human)
Voltage-dependent calcium channel subunit alpha-2/delta-2Voltage-gated calcium channel subunit alpha-2/delta-2Homo sapiens (human)
Sodium/potassium-transporting ATPase subunit alpha-1 Na(+)/K(+) ATPase alpha-1 subunit; EC 7.2.2.13; Sodium pump subunit alpha-1Homo sapiens (human)
Sodium/potassium-transporting ATPase subunit alpha-3Na(+)/K(+) ATPase alpha-3 subunit; EC 7.2.2.13; Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3Homo sapiens (human)
Sodium/potassium-transporting ATPase subunit beta-2Adhesion molecule in glia; AMOG; Sodium/potassium-dependent ATPase subunit beta-2Homo sapiens (human)
Sodium/potassium-transporting ATPase subunit alpha-2Na(+)/K(+) ATPase alpha-2 subunit; EC 7.2.2.13; Sodium pump subunit alpha-2Homo sapiens (human)
Sodium/potassium-transporting ATPase subunit beta-3Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3Homo sapiens (human)
Sodium/potassium-transporting ATPase subunit gammaNa(+)/K(+) ATPase subunit gamma; FXYD domain-containing ion transport regulator 2; Sodium pump gamma chainHomo sapiens (human)
Glutamate receptor ionotropic, NMDA 3AGluN3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; NR3A; NMDAR-LHomo sapiens (human)
Beta-endorphinCamelus dromedarius (Arabian camel)
Pro-opiomelanocortinPOMC; Corticotropin-lipotropinHomo sapiens (human)
Sodium/potassium-transporting ATPase subunit betaHomo sapiens (human)

Compounds (11)

CompoundDescription
Orthophosphate
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
NorepinephrinePrecursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic.
naloxoneA specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
DopamineOne of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
potassiumAn element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
SodiumA member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
SerotoninA biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
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