Page last updated: 2024-10-06

superpathway of coenzyme A biosynthesis I (bacteria)

Proteins (9)

ProteinSynonymsTaxonomy
Ketol-acid reductoisomerase (NADP(+))KARI; EC 1.1.1.86; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 2; Ketol-acid reductoisomerase type IIEscherichia coli K-12
2-dehydropantoate 2-reductaseEC 1.1.1.169; Ketopantoate reductase; KPA reductase; KPREscherichia coli K-12
Phosphopantetheine adenylyltransferaseEC 2.7.7.3; Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPATEscherichia coli K-12
Pantothenate kinaseEC 2.7.1.33; Pantothenic acid kinase; Rts proteinEscherichia coli K-12
3-methyl-2-oxobutanoate hydroxymethyltransferaseEC 2.1.2.11; Ketopantoate hydroxymethyltransferase; KPHMTEscherichia coli K-12
Pantothenate synthetasePS; EC 6.3.2.1; Pantoate--beta-alanine ligase; Pantoate-activating enzymeEscherichia coli K-12
Dephospho-CoA kinaseEC 2.7.1.24; Dephosphocoenzyme A kinaseEscherichia coli K-12
Aspartate 1-decarboxylaseEC 4.1.1.11; Aspartate alpha-decarboxylaseEscherichia coli K-12
Coenzyme A biosynthesis bifunctional protein CoaBCDNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine synthetase/decarboxylase; PPCS-PPCDCEscherichia coli K-12

Compounds (28)

CompoundDescription
diphosphoric acid
hydronium ion
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
Aspartate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
formaldehydeA highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
potassiumAn element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
n-pentylpantothenamideconverted to ethyldethia-coenzyme A, an antimetabolite; structure in first source
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
isopropyl methyl ketone
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
sodium borohydrideRN given refers to parent cpd
alpha-keto-isovaleric acid
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
CysteineA thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
CycloserineAntibiotic substance produced by Streptomyces garyphalus.
Cytidine MonophosphateCytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
Cytidine TriphosphateCytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.
hydroxylamineA colorless inorganic compound (HONH2) used in organic synthesis and as a reducing agent, due to its ability to donate nitric oxide.
hydrazineused as fuel in emergency power systems; see also record for hydrazine sulfate RN: 10034-93-2; RN given refers to parent cpd
4'-phosphopantothenate
Coenzyme A
dephosphocoenzyme A