Page last updated: 2024-10-06

superpathway of L-methionine biosynthesis (transsulfuration)

Proteins (9)

ProteinSynonymsTaxonomy
Bifunctional aspartokinase/homoserine dehydrogenase 1Aspartokinase I/homoserine dehydrogenase I; AKI-HDIEscherichia coli K-12
Aspartate aminotransferaseAspAT; EC 2.6.1.1; Transaminase AEscherichia coli K-12
Lysine-sensitive aspartokinase 3EC 2.7.2.4; Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase IIIEscherichia coli K-12
Cystathionine gamma-synthaseCGS; EC 2.5.1.48; O-succinylhomoserine (thiol)-lyaseEscherichia coli K-12
Homoserine O-succinyltransferaseHST; EC 2.3.1.46; Homoserine transsuccinylase; HTSEscherichia coli K-12
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseEC 2.1.1.14; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozymeEscherichia coli K-12
Methionine synthaseEC 2.1.1.13; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MSEscherichia coli K-12
Bifunctional aspartokinase/homoserine dehydrogenase 2Aspartokinase II/homoserine dehydrogenase II; AKII-HDIIEscherichia coli K-12
Aspartate-semialdehyde dehydrogenaseASA dehydrogenase; ASADH; EC 1.2.1.11; Aspartate-beta-semialdehyde dehydrogenaseEscherichia coli K-12

Compounds (29)

CompoundDescription
hydronium ion
Succinate
Ammonium
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
Aspartate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
boric acid
potassiumAn element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
SodiumA member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
succinyl-coenzyme A
iodoacetamideAn alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
alpha-Ketoglutarate
OxaloacetateAn anionic form of oxaloacetic acid.
diethyl pyrocarbonatePreservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
Edetic AcidA chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
aspartic semialdehydeRN given refers to cpd without isomeric designation
maleate
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
CysteineA thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
2-amino-4-oxo-5-chloropentanoateinhibitor of asparagine synthetase; structure