| Protein | Synonyms | Taxonomy |
|---|
| Phosphoribosylglycinamide formyltransferase | EC 2.1.2.2; 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART | Escherichia coli K-12 |
| Dihydrofolate reductase | EC 1.5.1.3 | Escherichia coli K-12 |
| Dihydrofolate synthase/folylpolyglutamate synthase | DHFS / FPGS; EC 6.3.2.12; EC 6.3.2.17; Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase; Folylpolyglutamate synthetase; Tetrahydrofolylpolyglutamate synthase | Escherichia coli K-12 |
| Aminodeoxychorismate lyase | EC 4.1.3.38; 4-amino-4-deoxychorismate lyase; ADC lyase; ADCL | Escherichia coli K-12 |
| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | EC 2.7.6.3; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK | Escherichia coli K-12 |
| Dihydropteroate synthase | DHPS; EC 2.5.1.15; Dihydropteroate pyrophosphorylase | Escherichia coli K-12 |
| GTP cyclohydrolase 1 | EC 3.5.4.16; GTP cyclohydrolase I; GTP-CH-I | Escherichia coli K-12 |
| Dihydromonapterin reductase | H(2)-MPt reductase; EC 1.5.1.50; Dihydrofolate reductase; DHFR; 1.5.1.3 | Escherichia coli K-12 |
| Dihydroneopterin aldolase | DHNA; EC 4.1.2.25; 7,8-dihydroneopterin 2'-epimerase; 7,8-dihydroneopterin aldolase; 7,8-dihydroneopterin epimerase; 5.1.99.8; Dihydroneopterin epimerase | Escherichia coli K-12 |
| Dihydroneopterin triphosphate diphosphatase | EC 3.6.1.67; Dihydroneopterin triphosphate pyrophosphatase; dATP pyrophosphohydrolase | Escherichia coli K-12 |
| Aminodeoxychorismate synthase component 2 | ADC synthase; ADCS; EC 2.6.1.85; 4-amino-4-deoxychorismate synthase component 2; Aminodeoxychorismate synthase, glutamine amidotransferase component | Escherichia coli K-12 |
| Aminodeoxychorismate synthase component 1 | ADC synthase; ADCS; EC 2.6.1.85; 4-amino-4-deoxychorismate synthase component 1 | Escherichia coli K-12 |
| Bifunctional protein FolD | | Escherichia coli K-12 |
| Compound | Description |
|---|
| diphosphoric acid | |
| hydronium ion | |
| Barium | An element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous. |
| Cesium | A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency. |
| Rubidium | An element that is an alkali metal. It has an atomic symbol Rb, atomic number 37, and atomic weight 85.47. It is used as a chemical reagent and in the manufacture of photoelectric cells. |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| Zinc | A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
| Orthophosphate | |
| trimethoprim | A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Uridine Triphosphate | Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety. |
| potassium | An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE. |
| Magnesium | A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION. |
| Sodium | A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| glycineamide ribonucleotide | structure |
| Pyruvic Acid | An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed) |
| thymidine 5'-triphosphate | RN given refers to parent cpd |
| adenosine monophosphate | Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| formate | |
| Cadaverine | A foul-smelling diamine formed by bacterial decarboxylation of lysine. |
| 4-aminobenzoic acid | An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS. |
| glutamate | |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| polyglutamine | RN given for (D)-isomer |
| Spermidine | A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine. |
| glycolaldehyde | structure |
| Spermine | A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. |