Pathways > SARS-CoV-2 activates/modulates innate and adaptive immune responses
Page last updated: 2024-10-06

SARS-CoV-2 activates/modulates innate and adaptive immune responses

Proteins (79)

ProteinSynonymsTaxonomy
NucleoproteinN; Nucleocapsid protein; NC; Protein NSevere acute respiratory syndrome coronavirus 2
Beclin-1Coiled-coil myosin-like BCL2-interacting protein; Protein GT197Homo sapiens (human)
Toll-like receptor 1EC 3.2.2.6; Toll/interleukin-1 receptor-like protein; TILHomo sapiens (human)
Interleukin-17AIL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8Homo sapiens (human)
Mitochondrial antiviral-signaling proteinMAVS; CARD adapter inducing interferon beta; Cardif; Interferon beta promoter stimulator protein 1; IPS-1; Putative NF-kappa-B-activating protein 031N; Virus-induced-signaling adapter; VISAHomo sapiens (human)
Interleukin-17 receptor AIL-17 receptor A; IL-17RA; CDw217Homo sapiens (human)
Interleukin-17FIL-17F; Cytokine ML-1Homo sapiens (human)
Inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; EC 2.7.11.10; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB; 2.7.11.1Homo sapiens (human)
Inhibitor of nuclear factor kappa-B kinase subunit alphaI-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; EC 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Transcription factor 16; TCF-16Homo sapiens (human)
Non-receptor tyrosine-protein kinase TYK2EC 2.7.10.2Homo sapiens (human)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1Homo sapiens (human)
Phosphatidylinositol 3-kinase catalytic subunit type 3PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3; EC 2.7.1.137; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34Homo sapiens (human)
Toll-like receptor 8Homo sapiens (human)
Toll-like receptor 7Homo sapiens (human)
Interferon regulatory factor 3IRF-3Homo sapiens (human)
Beta-2-microglobulinHomo sapiens (human)
Interferon-induced helicase C domain-containing protein 1EC 3.6.4.13; Clinically amyopathic dermatomyositis autoantigen 140 kDa; CADM-140 autoantigen; Helicase with 2 CARD domains; Helicard; Interferon-induced with helicase C domain protein 1; Melanoma differentiation-associated protein 5; MDA-5; Murabutide dowHomo sapiens (human)
Mitogen-activated protein kinase kinase kinase 7EC 2.7.11.25; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1Homo sapiens (human)
Tyrosine-protein kinase JAK1EC 2.7.10.2; Janus kinase 1; JAK-1Homo sapiens (human)
Serine/threonine-protein kinase TBK1EC 2.7.11.1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1Homo sapiens (human)
Stimulator of interferon genes proteinhSTING; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Transmembrane protein 173Homo sapiens (human)
Protein transport protein Sec23AhSec23A; SEC23-related protein AHomo sapiens (human)
Interferon alpha/beta receptor 1IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1Homo sapiens (human)
Pulmonary surfactant-associated protein DPSP-D; SP-D; Collectin-7; Lung surfactant protein DHomo sapiens (human)
Phosphoinositide 3-kinase regulatory subunit 4PI3-kinase regulatory subunit 4; EC 2.7.11.1; PI3-kinase p150 subunit; Phosphoinositide 3-kinase adaptor proteinHomo sapiens (human)
NF-kappa-B essential modulatorNEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifierHomo sapiens (human)
NACHT, LRR and PYD domains-containing protein 3 Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; Cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1Homo sapiens (human)
Signal transducer and activator of transcription 2 p113Homo sapiens (human)
Toll-like receptor 2EC 3.2.2.6; Toll/interleukin-1 receptor-like protein 4Homo sapiens (human)
CREB-binding proteinHistone lysine acetyltransferase CREBBP; 2.3.1.48; Protein-lysine acetyltransferase CREBBP; 2.3.1.-Homo sapiens (human)
ORF8 proteinORF8; Non-structural protein 8; ns8Severe acute respiratory syndrome coronavirus 2
E3 SUMO-protein ligase RanBP2EC 2.3.2.-; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2; RanBP2; p270Homo sapiens (human)
Membrane proteinM; E1 glycoprotein; Matrix glycoprotein; Membrane glycoproteinSevere acute respiratory syndrome coronavirus 2
Nuclear pore complex protein Nup155155 kDa nucleoporin; Nucleoporin Nup155Homo sapiens (human)
Mannan-binding lectin serine protease 1EC 3.4.21.-; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; Mannose-binding lectin-associated serine protease 1; MASP-1; Mannose-binding protein-associated serine protease; Ra-reactive factor serine protease p100; RaRF; SHomo sapiens (human)
Importin subunit alpha-1Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alphaHomo sapiens (human)
TNF receptor-associated factor 6EC 2.3.2.27; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85; RING-type E3 ubiquitin transferase TRAF6Homo sapiens (human)
Cellular nucleic acid-binding proteinCNBP; Zinc finger protein 9Homo sapiens (human)
ORF3a proteinORF3a; Accessory protein 3a; Protein 3a; Protein U274; Protein X1Severe acute respiratory syndrome coronavirus 2
ORF6 proteinORF6; Accessory protein 6; Non-structural protein 6; ns6; Protein X3Severe acute respiratory syndrome coronavirus 2
TNF receptor-associated factor 3EC 2.3.2.27; CAP-1; CD40 receptor-associated factor 1; CRAF1; CD40-binding protein; CD40BP; LMP1-associated protein 1; LAP1; RING-type E3 ubiquitin transferase TRAF3Homo sapiens (human)
Antiviral innate immune response receptor RIG-IDEAD box protein 58; Probable ATP-dependent RNA helicase DDX58; 3.6.4.13; RIG-I-like receptor 1; RLR-1; Retinoic acid-inducible gene 1 protein; RIG-1; Retinoic acid-inducible gene I protein; RIG-IHomo sapiens (human)
Nuclear pore complex protein Nup8888 kDa nucleoporin; Nucleoporin Nup88Homo sapiens (human)
mRNA export factorRae1 protein homolog; mRNA-associated protein mrnp 41Homo sapiens (human)
Nuclear pore membrane glycoprotein 210Nuclear pore protein gp210; Nuclear envelope pore membrane protein POM 210; POM210; Nucleoporin Nup210; Pore membrane protein of 210 kDaHomo sapiens (human)
Interleukin-17 receptor CIL-17 receptor C; IL-17RC; Interleukin-17 receptor homolog; IL17Rhom; Interleukin-17 receptor-like protein; IL-17RL; ZcytoR14Homo sapiens (human)
Nucleoporin NUP42NLP-1; NUP42 homolog; Nucleoporin hCG1; Nucleoporin-42; Nucleoporin-like protein 2Homo sapiens (human)
Mitochondrial import receptor subunit TOM70Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; Translocase of outer mitochondrial membrane protein 70Homo sapiens (human)
Ubiquitin-like protein ISG15Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; IP17; Ubiquitin cross-reactive protein; hUCRPHomo sapiens (human)
Nucleoprotein TPRMegator; NPC-associated intranuclear protein; Translocated promoter region proteinHomo sapiens (human)
Nuclear pore complex protein Nup214214 kDa nucleoporin; Nucleoporin Nup214; Protein CANHomo sapiens (human)
Nuclear pore glycoprotein p6262 kDa nucleoporin; Nucleoporin Nup62Homo sapiens (human)
Nuclear pore complex protein Nup153153 kDa nucleoporin; Nucleoporin Nup153Homo sapiens (human)
Protein SEC13 homologGATOR complex protein SEC13; SEC13-like protein 1; SEC13-related proteinHomo sapiens (human)
Nuclear pore complex protein Nup107107 kDa nucleoporin; Nucleoporin Nup107Homo sapiens (human)
NACHT, LRR and PYD domains-containing protein 12Monarch-1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxideHomo sapiens (human)
Nuclear pore complex protein Nup160160 kDa nucleoporin; Nucleoporin Nup160Homo sapiens (human)
E3 ubiquitin/ISG15 ligase TRIM25EC 6.3.2.n3; Estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM25; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc fingHomo sapiens (human)
Triokinase/FMN cyclaseBifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)Homo sapiens (human)
Nucleoporin NUP188hNup188Homo sapiens (human)
La-related protein 1La ribonucleoprotein domain family member 1Homo sapiens (human)
Beclin 1-associated autophagy-related key regulatorBarkor; Autophagy-related protein 14-like protein; Atg14LHomo sapiens (human)
Nucleoporin p5454 kDa nucleoporinHomo sapiens (human)
Nuclear pore complex protein Nup9393 kDa nucleoporin; Nucleoporin Nup93Homo sapiens (human)
Nucleoporin Nup43Nup107-160 subcomplex subunit Nup43; p42Homo sapiens (human)
Nucleoporin Nup37p37; Nup107-160 subcomplex subunit Nup37Homo sapiens (human)
Nucleoporin NUP3535 kDa nucleoporin; Mitotic phosphoprotein 44; MP-44; Nuclear pore complex protein Nup53; Nucleoporin NUP53Homo sapiens (human)
Nuclear pore complex protein Nup133133 kDa nucleoporin; Nucleoporin Nup133Homo sapiens (human)
Nuclear pore complex protein Nup205205 kDa nucleoporin; Nucleoporin Nup205Homo sapiens (human)
Interferon regulatory factor 7IRF-7Homo sapiens (human)
Suppressor of IKBKE 1Suppressor of IKK-epsilonHomo sapiens (human)
Nucleoporin NDC1hNDC1; Transmembrane protein 48Homo sapiens (human)
Nuclear pore complex protein Nup8585 kDa nucleoporin; FROUNT; Nucleoporin Nup75; Nucleoporin Nup85; Pericentrin-1Homo sapiens (human)
AladinAdracalinHomo sapiens (human)
Nuclear pore complex protein Nup5050 kDa nucleoporin; Nuclear pore-associated protein 60 kDa-like; Nucleoporin Nup50Homo sapiens (human)
GTP-binding protein SAR1bGTP-binding protein B; GTBPBHomo sapiens (human)
Envelope small membrane proteinE; sM proteinSevere acute respiratory syndrome coronavirus 2
ORF7a proteinORF7a; Accessory protein 7a; Protein U122; Protein X4Severe acute respiratory syndrome coronavirus 2
ORF9b proteinORF9b; Accessory protein 9b; ORF-9b; Protein 9bSevere acute respiratory syndrome coronavirus 2

Compounds (8)

CompoundDescription
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
potassiumAn element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.