Page last updated: 2024-10-06

L-lysine biosynthesis I

Proteins (16)

ProteinSynonymsTaxonomy
4-hydroxy-tetrahydrodipicolinate synthaseHTPA synthase; EC 4.3.3.7Escherichia coli K-12
Succinyl-diaminopimelate desuccinylaseSDAP desuccinylase; EC 3.5.1.18; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolaseHaemophilus influenzae Rd KW20
Acetylornithine/succinyldiaminopimelate aminotransferaseACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17Escherichia coli K-12
Lysine-sensitive aspartokinase 3EC 2.7.2.4; Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase IIIEscherichia coli K-12
4-hydroxy-tetrahydrodipicolinate synthaseHTPA synthase; EC 4.3.3.7Corynebacterium glutamicum ATCC 13032
AspartokinaseEC 2.7.2.4; Aspartate kinaseCorynebacterium glutamicum ATCC 13032
4-hydroxy-tetrahydrodipicolinate reductaseHTPA reductase; EC 1.17.1.8Escherichia coli K-12
Diaminopimelate decarboxylaseDAP decarboxylase; DAPDC; EC 4.1.1.20Escherichia coli K-12
Diaminopimelate epimeraseDAP epimerase; EC 5.1.1.7; PLP-independent amino acid racemaseEscherichia coli K-12
Phosphoserine aminotransferaseEC 2.6.1.52; Phosphohydroxythreonine aminotransferase; PSATEscherichia coli K-12
4-hydroxy-tetrahydrodipicolinate reductaseHTPA reductase; EC 1.17.1.8Corynebacterium glutamicum ATCC 13032
4-hydroxy-tetrahydrodipicolinate reductaseHTPA reductase; EC 1.17.1.8Mycobacterium tuberculosis H37Rv
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseEC 2.3.1.117; Succinyl-CoA: tetrahydrodipicolinate N-succinyltransferase; Tetrahydrodipicolinate N-succinyltransferase; THDP succinyltransferase; THP succinyltransferase; Tetrahydropicolinate succinylaseEscherichia coli K-12
Aspartate-semialdehyde dehydrogenaseASA dehydrogenase; ASADH; EC 1.2.1.11; Aspartate-beta-semialdehyde dehydrogenaseEscherichia coli K-12
Succinyl-diaminopimelate desuccinylaseSDAP desuccinylase; EC 3.5.1.18; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolaseEscherichia coli K-12
DapC Bordetella pertussis

Compounds (29)

CompoundDescription
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
Succinate
Ammonium
CopperA heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
dimercaprolAn anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
Aspartate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
boric acid
potassiumAn element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
SodiumA member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
succinyl-coenzyme A
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
alpha-Ketoglutarate
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
2,6-pyridine dicarboxylate
aspartic semialdehydeRN given refers to cpd without isomeric designation
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
bromopyruvate
hydroxylamineA colorless inorganic compound (HONH2) used in organic synthesis and as a reducing agent, due to its ability to donate nitric oxide.
Coenzyme A
2-amino-4-oxo-5-chloropentanoateinhibitor of asparagine synthetase; structure