## 1,2-bis(4-pyridyl)ethene: A Versatile Building Block for Materials Science
**1,2-bis(4-pyridyl)ethene** (abbreviated as BPE) is an organic compound with the formula C12H10N2. It consists of two pyridine rings linked by an ethene (ethylene) bridge.
**Why is it important for research?**
BPE is a highly versatile building block for the synthesis of various materials with interesting properties. Here's a breakdown of its key applications and research interest:
**1. Coordination Polymers and Metal-Organic Frameworks (MOFs):**
* BPE possesses two pyridine rings that act as strong coordination sites for metal ions. This enables the formation of diverse coordination polymers and MOFs with tailored structures and functionalities.
* These materials exhibit potential applications in areas such as:
* **Gas adsorption and separation:** For storage and selective capture of gases like CO2, H2, and methane.
* **Catalysis:** As heterogeneous catalysts for various organic transformations.
* **Sensing:** For detecting specific molecules or ions due to their unique sensing properties.
**2. Organic Electronics and Optoelectronics:**
* BPE's conjugated structure and electron-rich pyridine rings allow it to exhibit interesting electronic and optical properties.
* It can be incorporated into organic electronic devices like:
* **Organic light-emitting diodes (OLEDs):** For efficient and colorful displays.
* **Organic solar cells:** To enhance their efficiency and stability.
* **Organic field-effect transistors (OFETs):** For flexible and low-cost electronic applications.
**3. Supramolecular Chemistry:**
* BPE can form self-assembled structures through non-covalent interactions like hydrogen bonding and π-π stacking.
* This ability leads to:
* **Supramolecular gels and polymers:** With potential applications in bio-mimicking, drug delivery, and sensors.
* **Self-healing materials:** Capable of repairing themselves after damage.
**4. Other Applications:**
* **Liquid crystals:** BPE derivatives can act as liquid crystal materials used in display technologies and other applications.
* **Luminescent materials:** Some derivatives of BPE exhibit strong luminescence, which can be utilized in sensors, lighting, and biological imaging.
**Overall, 1,2-bis(4-pyridyl)ethene is a valuable building block in materials science research, offering a wide range of applications with significant potential across various fields.**
**Current research focus**:
Ongoing research aims to develop new synthetic strategies for BPE-based materials, explore their structure-property relationships, and optimize their performance for specific applications. The synthesis of BPE-based polymers, MOFs, and organic electronic devices is currently a hot topic in materials science research.
1,2-bis(4-pyridyl)ethene: structure in first source
ID Source | ID |
---|---|
PubMed CID | 776222 |
CHEMBL ID | 67033 |
SCHEMBL ID | 107198 |
MeSH ID | M0574586 |
Synonym |
---|
13362-78-2 |
4-[(e)-2-(4-pyridyl)vinyl]pyridine |
pyridine, 4,4'-[(e)-1,2-ethenediyl]bis- |
nsc-11470 |
1,2-bis(4-pyridyl)ethylene |
wln: t6nj d1u1- dt6nj |
1135-32-6 |
1,2-di-4-pyridylethene |
4-(4-pyridylvinyl)pyridine |
pyridine,4'-vinylenedi- |
4,4'-vinylenedipyridine |
nsc11470 |
pyridine,4'-(1,2-ethenediyl)bis- |
mls000737950 , |
trans-1,2-bis(4-pyridyl)ethylene |
pyridine, 4-(2-(pyridyl-4)ethenyl)-, trans- |
pyridine, 4,4'-(1,2-ethenediyl)bis-, (e)- |
IDI1_030070 |
1,2-di(4-pyridyl)ethylene, 97% |
smr000033593 |
4-[(e)-2-pyridin-4-ylvinyl]pyridine |
1,2-di(4-pyridyl)ethylene |
D0276 |
AKOS000278338 |
CHEMBL67033 , |
4-[(e)-2-pyridin-4-ylethenyl]pyridine |
HMS1513I16 |
bdbm50279893 |
4-[(e)-2-(4-pyridyl)vinyl]pyridine;(e)-1,2-di(pyridin-4-yl)ethene |
A806655 |
NCGC00246917-01 |
trans-1,2-bis(4-pyridyl)ethene |
pyridine, 4,4'-(1e)-1,2-ethenediylbis- |
trans-4,4'-vinylenedipyridine |
einecs 236-432-3 |
1,2-di(pyridin-4-yl)ethene |
nsc 11470 |
pyridine, 4,4'-vinylenedi- |
ai3-61802 |
pyridine, 4,4'-(1,2-ethenediyl)bis- |
einecs 214-491-6 |
HMS2748A14 |
GC10195 |
(e)-1,2-di(pyridin-4-yl)ethene |
SCHEMBL107198 |
trans-1,2-bis (4-pyridyl) ethylene |
trans-1,2-bis(4-pyridyl) ethylene |
1,2-bis(4-pyridyl)ethene |
AKOS025149311 |
4-[(e)-2-(4-pyridinyl)ethenyl]pyridine |
pyridine, 4,4'-vinylenedi-, (e)- |
trans-4,4'-dipyridylethylene |
1,2-di-(4-pyridyl)ethylene |
J-514037 |
mfcd00006448 |
SR-01000596921-1 |
sr-01000596921 |
trans-1.2-bis(4-pyridyl)ethylene |
J-006422 |
4-[(1e)-2-(pyridin-4-yl)ethenyl]pyridine |
4,4-vinylenedipyridine |
BCP04301 |
F10215 |
DS-16057 |
pyridine,4,4'-(1,2-ethenediyl)bis- |
DTXSID201014763 |
AMY39360 |
1,2-bis(4-pyridyl)ethylene 4,4'-vinylenedipyridine |
CS-0173132 |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
glp-1 receptor, partial | Homo sapiens (human) | Potency | 28.1838 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 50.1187 | 3.5481 | 19.5427 | 44.6684 | AID743266 |
Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 11.2202 | 1.9953 | 25.5327 | 50.1187 | AID624287 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
negative regulation of inflammatory response to antigenic stimulus | Guanine nucleotide-binding protein G | Homo sapiens (human) |
renal water homeostasis | Guanine nucleotide-binding protein G | Homo sapiens (human) |
G protein-coupled receptor signaling pathway | Guanine nucleotide-binding protein G | Homo sapiens (human) |
regulation of insulin secretion | Guanine nucleotide-binding protein G | Homo sapiens (human) |
cellular response to glucagon stimulus | Guanine nucleotide-binding protein G | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
G protein activity | Guanine nucleotide-binding protein G | Homo sapiens (human) |
adenylate cyclase activator activity | Guanine nucleotide-binding protein G | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
plasma membrane | Guanine nucleotide-binding protein G | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (7.69) | 29.6817 |
2010's | 11 (84.62) | 24.3611 |
2020's | 1 (7.69) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.97) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 13 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |