Page last updated: 2024-12-09

1,2-bis(4-pyridyl)ethene

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Description

## 1,2-bis(4-pyridyl)ethene: A Versatile Building Block for Materials Science

**1,2-bis(4-pyridyl)ethene** (abbreviated as BPE) is an organic compound with the formula C12H10N2. It consists of two pyridine rings linked by an ethene (ethylene) bridge.

**Why is it important for research?**

BPE is a highly versatile building block for the synthesis of various materials with interesting properties. Here's a breakdown of its key applications and research interest:

**1. Coordination Polymers and Metal-Organic Frameworks (MOFs):**

* BPE possesses two pyridine rings that act as strong coordination sites for metal ions. This enables the formation of diverse coordination polymers and MOFs with tailored structures and functionalities.
* These materials exhibit potential applications in areas such as:
* **Gas adsorption and separation:** For storage and selective capture of gases like CO2, H2, and methane.
* **Catalysis:** As heterogeneous catalysts for various organic transformations.
* **Sensing:** For detecting specific molecules or ions due to their unique sensing properties.

**2. Organic Electronics and Optoelectronics:**

* BPE's conjugated structure and electron-rich pyridine rings allow it to exhibit interesting electronic and optical properties.
* It can be incorporated into organic electronic devices like:
* **Organic light-emitting diodes (OLEDs):** For efficient and colorful displays.
* **Organic solar cells:** To enhance their efficiency and stability.
* **Organic field-effect transistors (OFETs):** For flexible and low-cost electronic applications.

**3. Supramolecular Chemistry:**

* BPE can form self-assembled structures through non-covalent interactions like hydrogen bonding and π-π stacking.
* This ability leads to:
* **Supramolecular gels and polymers:** With potential applications in bio-mimicking, drug delivery, and sensors.
* **Self-healing materials:** Capable of repairing themselves after damage.

**4. Other Applications:**

* **Liquid crystals:** BPE derivatives can act as liquid crystal materials used in display technologies and other applications.
* **Luminescent materials:** Some derivatives of BPE exhibit strong luminescence, which can be utilized in sensors, lighting, and biological imaging.

**Overall, 1,2-bis(4-pyridyl)ethene is a valuable building block in materials science research, offering a wide range of applications with significant potential across various fields.**

**Current research focus**:

Ongoing research aims to develop new synthetic strategies for BPE-based materials, explore their structure-property relationships, and optimize their performance for specific applications. The synthesis of BPE-based polymers, MOFs, and organic electronic devices is currently a hot topic in materials science research.

1,2-bis(4-pyridyl)ethene: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID776222
CHEMBL ID67033
SCHEMBL ID107198
MeSH IDM0574586

Synonyms (69)

Synonym
13362-78-2
4-[(e)-2-(4-pyridyl)vinyl]pyridine
pyridine, 4,4'-[(e)-1,2-ethenediyl]bis-
nsc-11470
1,2-bis(4-pyridyl)ethylene
wln: t6nj d1u1- dt6nj
1135-32-6
1,2-di-4-pyridylethene
4-(4-pyridylvinyl)pyridine
pyridine,4'-vinylenedi-
4,4'-vinylenedipyridine
nsc11470
pyridine,4'-(1,2-ethenediyl)bis-
mls000737950 ,
trans-1,2-bis(4-pyridyl)ethylene
pyridine, 4-(2-(pyridyl-4)ethenyl)-, trans-
pyridine, 4,4'-(1,2-ethenediyl)bis-, (e)-
IDI1_030070
1,2-di(4-pyridyl)ethylene, 97%
smr000033593
4-[(e)-2-pyridin-4-ylvinyl]pyridine
1,2-di(4-pyridyl)ethylene
D0276
AKOS000278338
CHEMBL67033 ,
4-[(e)-2-pyridin-4-ylethenyl]pyridine
HMS1513I16
bdbm50279893
4-[(e)-2-(4-pyridyl)vinyl]pyridine;(e)-1,2-di(pyridin-4-yl)ethene
A806655
NCGC00246917-01
trans-1,2-bis(4-pyridyl)ethene
pyridine, 4,4'-(1e)-1,2-ethenediylbis-
trans-4,4'-vinylenedipyridine
einecs 236-432-3
1,2-di(pyridin-4-yl)ethene
nsc 11470
pyridine, 4,4'-vinylenedi-
ai3-61802
pyridine, 4,4'-(1,2-ethenediyl)bis-
einecs 214-491-6
HMS2748A14
GC10195
(e)-1,2-di(pyridin-4-yl)ethene
SCHEMBL107198
trans-1,2-bis (4-pyridyl) ethylene
trans-1,2-bis(4-pyridyl) ethylene
1,2-bis(4-pyridyl)ethene
AKOS025149311
4-[(e)-2-(4-pyridinyl)ethenyl]pyridine
pyridine, 4,4'-vinylenedi-, (e)-
trans-4,4'-dipyridylethylene
1,2-di-(4-pyridyl)ethylene
J-514037
mfcd00006448
SR-01000596921-1
sr-01000596921
trans-1.2-bis(4-pyridyl)ethylene
J-006422
4-[(1e)-2-(pyridin-4-yl)ethenyl]pyridine
4,4-vinylenedipyridine
BCP04301
F10215
DS-16057
pyridine,4,4'-(1,2-ethenediyl)bis-
DTXSID201014763
AMY39360
1,2-bis(4-pyridyl)ethylene 4,4'-vinylenedipyridine
CS-0173132
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glp-1 receptor, partialHomo sapiens (human)Potency28.18380.01846.806014.1254AID624417
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency50.11873.548119.542744.6684AID743266
Guanine nucleotide-binding protein GHomo sapiens (human)Potency11.22021.995325.532750.1187AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's11 (84.62)24.3611
2020's1 (7.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.97

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.97 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.60 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.97)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]