Page last updated: 2024-09-03

carglumic acid and ammonium hydroxide

carglumic acid has been researched along with ammonium hydroxide in 28 studies

*Ammonium Hydroxide: The hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution. [MeSH]

Compound Research Comparison

Studies (carglumic acid)	Trials (carglumic acid)	Recent Studies (post-2010) (carglumic acid)	Studies (ammonium hydroxide)	Trials (ammonium hydroxide)	Recent Studies (post-2010) (ammonium hydroxide)
129	18	87	29,152	577	9,136

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (10.71)	18.7374
1990's	9 (32.14)	18.2507
2000's	6 (21.43)	29.6817
2010's	10 (35.71)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Alvaro, I; Arilla, E; Bodega, G; Boyano, MC	1
Felipo, V; Grau, E; Grisolía, S; Miñana, MD	1
Costell, M; Grisolía, S; O'Connor, JE	1
Lyftogt, C; Raphael, D; Zieve, L	1
Grisolía, S; Jordá, A; O'Connor, JE	1
Bourgeois, J; Colombo, JP; Guffon, N; Guibaud, P; Rabier, D; Vianey-Saban, C	1
Bardet, J; Cadoudal, M; Drouin, V; Kuchler, G; Meyer-Gast, D; Poggi-Travert, F; Rabier, D; Saudubray, JM	1
Donati, MA; Filippi, L; Novembre, E; Zammarchi, E	1
Colombo, JP; Dryburgh, FJ; Hinnie, J; Wermuth, B	1
Cho, H; Kim, S; Kim, WH; Kwak, YS; Lee, JH; Paik, WK	1
Leonard, JV; Morris, AA; Oddie, SJ; Pourfarzam, M; Richmond, SW; Worthington, V	1
Erwa, W; Plecko, B; Wermuth, B	1
Cho, H; Jeon, SH; Kim, S; Kim, WH; Lee, JH; Paik, WK; Park, H; Yun, C	1
Bélanger-Quintana, A; García, MJ; Martínez-Pardo, M; Pallarés, E; Torres, J; Ugarte, M; Wermuth, B	1
Caldovic, L; Daikhin, Y; McCarter, RJ; Morizono, H; Nissim, I; Tuchman, M; Yudkoff, M	1
Jones, S; Morris, AA; Reed, CA; Vijay, S; Walter, JH	1
Burton, B; Caldovic, L; Daikhin, Y; Horyn, O; Korson, M; Nissim, I; Tuchman, M; Yudkoff, M	1
Bisset, WM; Galloway, PG; Pieterse, L; Robinson, PH; Schwahn, BC	1
Coker, M; Duran, M; Habif, S; Kalkan Ucar, S; Karapinar, B; Kitis, O; Saz, EU; Ucar, H	1
Donati, MA; Filippi, L; Fiorini, P; Gozzini, E; la Marca, G; Malvagia, S	1
Ah Mew, N; Daikhin, Y; McCarter, R; Nissim, I; Tuchman, M; Yudkoff, M	1
Biberoglu, G; Ezgu, FS; Hasanoglu, A; Kasapkara, CS; Okur, I; Tumer, L	1
Ackermans, MT; Chamuleau, RA; Elferink, RP; Hakvoort, TB; Hoekstra, R; Lamers, WH; Nibourg, GA; van der Hoeven, TV; van Gulik, TM	1
Abacan, M; Boneh, A	1
Ah Mew, N; Daikhin, Y; Lichter-Konecki, U; McCarter, R; Nissim, I; Tuchman, M; Yudkoff, M	1
Abdul Aziz, F; Abdullah, IS; Hassim, H; Leong, HY; Mohamed, Z; Ngu, LH; Sthaneshwar, P; Teh, SH; Yap, S	1
Baruteau, J; Cano, A; Chakrapani, A; Coker, M; Couce, ML; Del Toro, M; Delgado, MB; Donati, MA; Garcia-Cazorla, A; Gil-Ortega, D; Gomez-de Quero, P; Guffon, N; Hofstede, FC; Kalkan-Ucar, S; Lama-More, R; Le Mouhaer, J; Martinez-Pardo Casanova, M; Molina, A; Papadia, F; Pichard, S; Plisson, C; Rosello, P; Valayannopoulos, V	1
Ah Mew, N; Chakrapani, A; Häberle, J; Longo, N	1

Reviews

1 review(s) available for carglumic acid and ammonium hydroxide

Article	Year
Hyperammonaemia in classic organic acidaemias: a review of the literature and two case histories. Orphanet journal of rare diseases, 2018, 12-06, Volume: 13, Issue:1 Topics: Ammonia; Glucose; Glutamates; Humans; Hyperammonemia; Propionic Acidemia	2018

Trials

4 trial(s) available for carglumic acid and ammonium hydroxide

Article	Year
N-carbamylglutamate markedly enhances ureagenesis in N-acetylglutamate deficiency and propionic acidemia as measured by isotopic incorporation and blood biomarkers. Pediatric research, 2008, Volume: 64, Issue:2 Topics: Acetyl Coenzyme A; Adult; Amino Acids; Ammonia; Biomarkers; Carbon Dioxide; Carbon Isotopes; Child; Feasibility Studies; Female; Glutamates; Humans; Male; Metabolic Diseases; Middle Aged; Propionates; Urea	2008
N-carbamylglutamate augments ureagenesis and reduces ammonia and glutamine in propionic acidemia. Pediatrics, 2010, Volume: 126, Issue:1 Topics: Administration, Oral; Adolescent; Ammonia; Blood Chemical Analysis; Child; Child, Preschool; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Glutamates; Glutamine; Humans; Infant; Male; Probability; Propionic Acidemia; Prospective Studies; Risk Assessment; Treatment Outcome; Urea	2010
Augmenting ureagenesis in patients with partial carbamyl phosphate synthetase 1 deficiency with N-carbamyl-L-glutamate. The Journal of pediatrics, 2014, Volume: 165, Issue:2 Topics: Adolescent; Adult; Ammonia; Carbamoyl-Phosphate Synthase I Deficiency Disease; Child; Child, Preschool; Female; Glutamates; Glutamine; Humans; Linear Models; Male; Mass Spectrometry; Treatment Outcome; Urea; Young Adult	2014
Carglumic acid enhances rapid ammonia detoxification in classical organic acidurias with a favourable risk-benefit profile: a retrospective observational study. Orphanet journal of rare diseases, 2016, Mar-31, Volume: 11 Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Female; Glutamates; Humans; Hyperammonemia; Infant, Newborn; Male; Propionic Acidemia; Retrospective Studies; Treatment Outcome	2016

Other Studies

23 other study(ies) available for carglumic acid and ammonium hydroxide

Article	Year
Somatostatin binding reduced by ammonium acetate in the rat hippocampus can be reversed by treatment with N-carbamyl-L-glutamate plus L-arginine. Synapse (New York, N.Y.), 1992, Volume: 12, Issue:1 Topics: Acetates; Ammonia; Animals; Arginine; Drug Administration Schedule; Female; Glutamates; Glutamine; Hippocampus; Rats; Rats, Wistar; Receptors, Somatostatin; Somatostatin; Time Factors	1992
Treatment of hyperammonemia with carbamylglutamate in rats. Hepatology (Baltimore, Md.), 1992, Volume: 15, Issue:3 Topics: Administration, Oral; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Dietary Proteins; Enzyme Activation; Glutamates; Liver; Male; Rats; Rats, Inbred Strains; Reference Values	1992
Carbamyl glutamate prevents the potentiation of ammonia toxicity by sodium benzoate. European journal of pediatrics, 1989, Volume: 148, Issue:6 Topics: Ammonia; Animals; Benzoates; Benzoic Acid; Drug Synergism; Glutamates; Mice; Urea	1989
Ammonia toxicity: comparative protective effect of various arginine and ornithine derivatives, aspartate, benzoate, and carbamyl glutamate. Metabolic brain disease, 1986, Volume: 1, Issue:1 Topics: Ammonia; Ammonium Chloride; Animals; Arginine; Aspartic Acid; Benzoates; Brain Diseases; Coma; Dose-Response Relationship, Drug; Glutamates; Male; Rats; Rats, Inbred Strains	1986
Acute and chronic effects of carbamyl glutamate on blood urea and ammonia. European journal of pediatrics, 1985, Volume: 143, Issue:3 Topics: Ammonia; Animals; Glutamates; Male; Mice; Rats; Rats, Inbred Strains; Time Factors; Urea	1985
A new neonatal case of N-acetylglutamate synthase deficiency treated by carbamylglutamate. Journal of inherited metabolic disease, 1995, Volume: 18, Issue:1 Topics: Acetyltransferases; Amino Acid Metabolism, Inborn Errors; Amino Acids; Amino-Acid N-Acetyltransferase; Ammonia; Glutamates; Humans; Infant, Newborn; Male; Ornithine Carbamoyltransferase Deficiency Disease	1995
Therapeutic use of carbamylglutamate in the case of carbamoyl-phosphate synthetase deficiency. Journal of inherited metabolic disease, 1996, Volume: 19, Issue:2 Topics: Ammonia; Arginine; Carbamoyl-Phosphate Synthase (Ammonia); Child, Preschool; Citrulline; Glutamates; Glutamic Acid; Glutamine; Humans; Male	1996
Biochemical evaluation of a patient with a familial form of leucine-sensitive hypoglycemia and concomitant hyperammonemia. Metabolism: clinical and experimental, 1996, Volume: 45, Issue:8 Topics: Adult; Ammonia; Drug Resistance; Female; Glutamates; Humans; Hyperinsulinism; Hypoglycemia; Infant; Leucine; Male	1996
N-Acetylglutamate synthetase deficiency responding to carbamylglutamate. Journal of inherited metabolic disease, 1997, Volume: 20, Issue:6 Topics: Acetyltransferases; Amino-Acid N-Acetyltransferase; Ammonia; Brain Diseases; Consanguinity; Fever; Glutamates; Humans; Infant; Male; Paraplegia	1997
N-carbamoyl-L-glutamate plus L-arginine can protect ammonia intoxication in rats with reduced functional liver mass. Biochemical and biophysical research communications, 1998, Jul-20, Volume: 248, Issue:2 Topics: Acetates; Ammonia; Animals; Arginine; Behavior, Animal; Blood Urea Nitrogen; Glutamates; Hepatectomy; Liver; Liver Diseases; Male; Organ Size; Rats; Rats, Sprague-Dawley	1998
N-acetylglutamate synthetase deficiency: favourable experience with carbamylglutamate. Journal of inherited metabolic disease, 1998, Volume: 21, Issue:8 Topics: Acetyltransferases; Amino-Acid N-Acetyltransferase; Ammonia; Citrulline; Consanguinity; Dietary Proteins; Female; Glutamates; Glutamine; Humans; Infant, Newborn; Mitochondria, Liver	1998
Partial N-acetylglutamate synthetase deficiency in a 13-year-old girl: diagnosis and response to treatment with N-carbamylglutamate. European journal of pediatrics, 1998, Volume: 157, Issue:12 Topics: Acetyltransferases; Adolescent; Amino-Acid N-Acetyltransferase; Ammonia; Female; Glutamates; Humans; Liver; Metabolism, Inborn Errors; Vomiting	1998
Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication. Journal of hepatology, 2001, Volume: 35, Issue:6 Topics: Acetates; Acute Disease; Ammonia; Animals; Arginine; Behavior, Animal; Carbamoyl-Phosphate Synthase (Ammonia); Dimethylnitrosamine; Drug Synergism; Glutamates; Liver Cirrhosis; Male; Poisoning; Rats; Rats, Sprague-Dawley; Time Factors	2001
Hyperammonaemia as a cause of psychosis in an adolescent. European journal of pediatrics, 2003, Volume: 162, Issue:11 Topics: Adolescent; Ammonia; Follow-Up Studies; Glutamates; Humans; Hyperammonemia; Male; Psychotic Disorders; Risk Assessment; Severity of Illness Index; Treatment Outcome	2003
Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate. The Journal of pediatrics, 2004, Volume: 145, Issue:4 Topics: Acetyltransferases; Adolescent; Adult; Amino-Acid N-Acetyltransferase; Ammonia; Ammonium Chloride; Blood Urea Nitrogen; Female; Glutamates; Glutamine; Humans; Nitrogen Isotopes; Urea	2004
N-carbamylglutamate for neonatal hyperammonaemia in propionic acidaemia. Journal of inherited metabolic disease, 2008, Volume: 31 Suppl 2 Topics: Ammonia; Biomarkers; Female; Glutamates; Humans; Hyperammonemia; Infant, Newborn; Intubation, Gastrointestinal; Male; Propionic Acidemia; Time Factors; Treatment Outcome	2008
Biochemical efficacy of N-carbamylglutamate in neonatal severe hyperammonaemia due to propionic acidaemia. European journal of pediatrics, 2010, Volume: 169, Issue:1 Topics: Ammonia; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glutamates; Humans; Hyperammonemia; Infant, Newborn; Propionic Acidemia; Renal Dialysis; Severity of Illness Index	2010
The first use of N-carbamylglutamate in a patient with decompensated maple syrup urine disease. Metabolic brain disease, 2009, Volume: 24, Issue:3 Topics: Acidosis; Ammonia; Brain; Child, Preschool; Consanguinity; Female; Glutamates; Humans; Infant, Newborn; Leucine; Magnetic Resonance Imaging; Maple Syrup Urine Disease	2009
N-carbamylglutamate in emergency management of hyperammonemia in neonatal acute onset propionic and methylmalonic aciduria. Neonatology, 2010, Volume: 97, Issue:3 Topics: Acute Disease; Amino Acid Metabolism, Inborn Errors; Ammonia; Emergency Medical Services; Female; Glutamates; Humans; Hyperammonemia; Infant, Newborn; Male; Methylmalonic Acid; Propionic Acidemia; Vitamin B 12 Deficiency	2010
N-carbamylglutamate treatment for acute neonatal hyperammonemia in isovaleric acidemia. European journal of pediatrics, 2011, Volume: 170, Issue:6 Topics: Acute Disease; Amino Acid Metabolism, Inborn Errors; Ammonia; Glutamates; Humans; Hyperammonemia; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Male; Treatment Outcome	2011
The HepaRG cell line is suitable for bioartificial liver application. The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:10 Topics: Ammonia; Apolipoprotein A-I; Biliary Tract; Carbamoyl-Phosphate Synthase (Ammonia); Cell Differentiation; Cell Line; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Epithelial Cells; Gene Expression Regulation; Glutamates; Hepatocytes; Humans; Liver; Liver Failure; Liver, Artificial; Nitrogen	2011
Use of carglumic acid in the treatment of hyperammonaemia during metabolic decompensation of patients with propionic acidaemia. Molecular genetics and metabolism, 2013, Volume: 109, Issue:4 Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Carnitine; Child, Preschool; Female; Glutamates; Humans; Hyperammonemia; Infant; Infant, Newborn; Male; Methylmalonyl-CoA Decarboxylase; Propionic Acidemia	2013
N-Carbamylglutamate Is an Effective Treatment for Acute Neonatal Hyperammonaemia in a Patient with Methylmalonic Aciduria. Neonatology, 2016, Volume: 109, Issue:4 Topics: Administration, Oral; Amino Acid Metabolism, Inborn Errors; Ammonia; Glutamates; Humans; Hyperammonemia; Infant, Newborn; Male; Nutritional Support; Treatment Outcome	2016