Compounds > 2,6-dihydroxynaphthalene
Page last updated: 2024-12-07

2,6-dihydroxynaphthalene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID93552
CHEMBL ID205074
CHEBI ID197110
SCHEMBL ID69484
MeSH IDM0464218

Synonyms (42)

Synonym
2-hydroxy-6-naphthol
2,6-naphthohydroquinone
nsc-62687
nsc62687
c.i. 76640
2,6-dihydroxynaphthalene ,
inchi=1/c10h8o2/c11-9-3-1-7-5-10(12)4-2-8(7)6-9/h1-6,11-12
2,6-naphthalenediol
581-43-1
naphthalene-2,6-diol
STK372685
2,6-dihydroxynaphthalene, 98%
D0956
CHEMBL205074
CHEBI:197110
A18935
AKOS005267146
nsc 62687
einecs 209-465-6
4xx2nd0257 ,
unii-4xx2nd0257
FT-0632432
BBL025841
6-hydroxy-2-naphthol
2,6-dihydroxynaphthaline
SCHEMBL69484
bdbm36285
2,6-dihdroxynaphthalene
2,6-dihydroxy naphthalene
2,6-dihydroxy-naphthalene
DTXSID7060384
W-105409
AC-24467
mfcd00004082
2,6-dihydroxynaphthalene, purum, >=96.0% (hplc)
CS-0059281
SY014758
AS-14437
EN300-123658
Q27260648
2,6-naphthalindiol
Z1255382953
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
naphtholsAny hydroxynaphthalene derivative that has a single hydroxy substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1059430Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 using L-tryptophan as substrate at 1 mM after 1 hr relative to control2013Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).
AID430240Induction of apoptosis in human wild type LoVo cells assessed as increase in hyplodiploid cells after 24 hrs by flow cytometry2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Chromane derivatives of small aromatic molecules: Chemoenzymatic synthesis and growth inhibitory activity on human tumor cell line LoVo WT.
AID261690Antiproliferative activity against human fibroblast HFL1 cells2006Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6
Selective antiproliferative activity of hydroxynaphthyl-beta-D-xylosides.
AID261691Antiproliferative activity against human bladder carcinoma T24 cells2006Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6
Selective antiproliferative activity of hydroxynaphthyl-beta-D-xylosides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.11

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.11 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.37 (4.65)
Search Engine Demand Index28.85 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.11)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzaldehyde
[no description available]		2.0810hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
catechol
[no description available]		2.0810catecholsallelochemical;
genotoxin;
plant metabolite
salicylic acid
Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).		2.0810monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
alpha-cyano-4-hydroxycinnamate
alpha-cyano-4-hydroxycinnamate: specific inhibitor of pyruvate transport in rat liver mitochondria & human erythrocytes; structure		2.0810
benzoxazolone
benzoxazolone: RN given refers to parent cpd; structure. 2-benzoxazolinone : A member of the class of benzoxazoles that is 2,3-dihydro-1,3-benzoxazole carrying an oxo group at position 2.		2.0810benzoxazoleallelochemical;
phytoalexin
4-nitrobenzoic acid
4-nitrobenzoic acid: RN given refers to parent cpd. 4-nitrobenzoic acid : A nitrobenzoic acid having the nitro group at the 4-position.		2.0810nitrobenzoic acid
3-methylsalicylic acid
3-methylsalicylic acid : A monohydroxybenzoic acid consisting of salicylic acid carrying a methyl group at the 3-position.		2.0810monohydroxybenzoic acidbacterial xenobiotic metabolite
1,5-dihydroxynaphthalene
[no description available]		2.4620
5-methylsalicylic acid
[no description available]		2.0810
2-naphthylamine
2-Naphthylamine: A naphthalene derivative with carcinogenic action.. 2-naphthylamine : A naphthylamine carrying the amino group at position 2.		2.0810naphthylaminecarcinogenic agent
2,3-dihydroxynaphthalene
2,3-naphthalenediol: structure in first source		2.0310naphthalenediol
4,4'-dihydroxybiphenyl
biphenyl-4,4'-diol : A member of the class of hydroxybiphenyls that is biphenyl with hydroxy groups at positions 4 and 4'.		2.0810hydroxybiphenyls
benzothiazole
benzothiazole: structure. benzothiazole : An organic heterobicyclic compound that is a fusion product between benzene and thiazole. The parent of the class of benzothiazoles.		2.0810benzothiazolesenvironmental contaminant;
plant metabolite;
xenobiotic
phenylhydrazine
[no description available]		2.0810phenylhydrazinesxenobiotic
dibenzothiazyl disulfide
dibenzothiazyl disulfide: vulcanizing accelerant. dibenzothiazol-2-yl disulfide : An organic disulfide resulting from the formal oxidative coupling of the thiol groups of two molecules of 1,3-benzothiazole-2-thiol. It is used as an accelerator in the rubber industry.		2.0810benzothiazoles;
organic disulfide		allergen
naphthoresorcinol
naphthoresorcinol: RN given refers to parent cpd		2.0310
2-naphthol
2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.		2.7330naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
2-aminobenzothiazole
[no description available]		2.0810benzothiazoles
4-methylcatechol
[no description available]		2.0810methylcatecholantioxidant;
carcinogenic agent;
hapten;
human metabolite;
plant metabolite
ninhydrin
Ninhydrin: 2,2-Dihydroxy-1H-indene-1,3-(2H)-dione. Reagent toxic to skin and mucus membranes. It is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.. ninhydrin : A member of the class of indanones that is indane-1,3-dione bearing two additional hydroxy substituents at position 2.		2.0810aromatic ketone;
beta-diketone;
indanones;
ketone hydrate		colour indicator;
human metabolite
hydroxyhydroquinone
benzene-1,2,4-triol : A benzenetriol carrying hydroxy groups at positions 1, 2 and 4.		2.0810benzenetriolmouse metabolite
1,4-naphthohydroquinone
naphthohydroquinone : A hydroxynaphthalene that is naphthalene-1,4-diol and its C-substituted derivatives.		2.0310naphthalenediol;
naphthohydroquinone
1,2-dihydroxynaphthalene
1,2-dihydroxynaphthalene: RN given refers to parent cpd		2.0310naphthalenediolmouse metabolite
6-hydroxyquinoline
quinolin-6-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 6.		2.0810monohydroxyquinoline
2,7-dihydroxynaphthalene
[no description available]		2.4620
pentafluorobenzoic acid
[no description available]		2.0810perfluorinated compound
1,3-indandione
1,3-indandione : A member of the class of indanones that is indane in which the hydrogens at positions 2 and 4 have been replaced by oxo groups.		2.0810aromatic ketone;
beta-diketone;
indanones
5-methylbenzimidazole
5-methylbenzimidazole: structure in first source. 5-methyl-1H-benzimidazole : A member of the class of imidazoles that is 1H-benzimidazole in which the hydrogen at position 5 is substituted by a methyl group.		2.0810imidazoles
2-hydrazinobenzothiazole
[no description available]		2.0810
3-acetylindole
3-acetylindole: structure in first source		2.0810
2-hydroxybenzothiazole
2-hydroxybenzothiazole : Benzothiazole substituted with a hydroxy group at the 2-position.		2.0810benzothiazole
phenylhydroquinone
phenylhydroquinone: major metabolite of o-phenylphenol; cleaves DNA; structure given in first source		2.0810
2-amino-4-methylbenzothiazole
2-amino-4-methylbenzothiazole: structure in first source		2.0810
2,2'-biphenol
biphenyl-2,2'-diol : A member of the class of hydroxybiphenyls carrying hydroxy groups at positions 2 and 2'.		2.0810hydroxybiphenyls
1,5-naphthalenediamine
1,5-diaminonaphthalene: structure in first source. naphthalene-1,5-diamine : A naphthalenediamine compound having amino substituents in the 1- and 5-positions.		2.0810naphthalenediaminecarcinogenic agent
salicylhydroxamic acid
[no description available]		2.0810hydroxamic acid;
phenols		antibacterial drug;
EC 1.11.2.2 (myeloperoxidase) inhibitor;
EC 3.5.1.5 (urease) inhibitor;
trypanocidal drug
5-fluorosalicylic acid
5-fluorosalicylic acid: structure given in first source; product from action of alkaline phosphatase on 5-fluorosalicyl phosphate; forms highly fluorescent terbium ternary complex		2.0810
1,8-diaminonaphthalene
1,8-diaminonaphthalene: structure in first source		2.0810
1,8-dihydroxynaphthalene
1,8-dihydroxynaphthalene: isolated from mutant of Wangiella dermatitidis; structure given in first source. naphthalene-1,8-diol : A member of the class of naphthalenediols that is naphthalene in which the hydrogens at positions 1 and 8 are replaced by hydroxy groups.		2.0310naphthalenediolfungal metabolite
4(5)-phenylimidazole
4(5)-phenylimidazole: tautomeric cpd; cytochrome P450 14alpha-sterol demethylase, CYP51 antagonist		2.0810
biphenyl-2-carboxylic acid
biphenyl-2-carboxylic acid: structure in first source		2.0810
2-(4-aminophenyl)ethylamine
2-(4-aminophenyl)ethylamine: used to prepare derivatives of reducing oligosaccharides; structure given in first source		2.0110
4-Methoxybenzamide
[no description available]		2.0810benzamides
2-(carboxymethylthio)benzothiazole
2-(carboxymethylthio)benzothiazole: oxidation product of 2-(hydroxyethylthio)benzothiazole; structure given in first source		2.0810
captax
captax: RN given refers to parent cpd. 1,3-benzothiazole-2-thiol : 1,3-Benzothiazole substituted at the 2-position with a sulfanyl group.		2.0810aryl thiol;
benzothiazoles		carcinogenic agent;
metabolite
4-nitrocatechol
4-nitrocatechol : A member of the class of catechols that is benzene-1,2-diol substituted by a nitro group at position 4.It is the by-product of the hydroxylation of p-nitrophenol.		2.0810C-nitro compound;
catechols		human xenobiotic metabolite;
lipoxygenase inhibitor
esculetin
esculetin: used in filters for absorption of ultraviolet light; structure. esculetin : A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.		2.0810hydroxycoumarinantioxidant;
plant metabolite;
ultraviolet filter
7-hydroxycoumarin-4-acetic acid
7-hydroxycoumarin-4-acetic acid: pH-indicator dye; structure in first source		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		02.0510
Colonic Neoplasms
Tumors or cancer of the COLON.		02.0510
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0110