Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | 3 | 0 | 0 | 3 |
Chain A, Membrane lipoprotein tmpC | 0 | 0 | 1 | 1 |
Chain A, Membrane lipoprotein tmpC | 0 | 0 | 1 | 1 |
Chain A, Membrane lipoprotein tmpC | 0 | 0 | 1 | 1 |
Chain A, Structure of PAE2307 in complex with adenosine | 0 | 0 | 1 | 1 |
Chain B, Structure of PAE2307 in complex with adenosine | 0 | 0 | 1 | 1 |
Chain A, ADENOSINE RECEPTOR A2A | 0 | 1 | 0 | 1 |
Chain A, ADENOSINE RECEPTOR A2A | 0 | 1 | 0 | 1 |
Chain A, tRNA (guanine-N(1)-)-methyltransferase | 0 | 0 | 1 | 1 |
Chain A, Uncharacterized protein MJ0883 | 0 | 0 | 1 | 1 |
AR protein | 5 | 0 | 0 | 5 |
signal transducer and activator of transcription 6, interleukin-4 induced | 1 | 0 | 0 | 1 |
regulator of G-protein signaling 4 | 2 | 0 | 0 | 2 |
glucocorticoid receptor [Homo sapiens] | 4 | 0 | 0 | 4 |
retinoid X nuclear receptor alpha | 4 | 0 | 0 | 4 |
estrogen nuclear receptor alpha | 6 | 0 | 0 | 6 |
NPYLR7B | 0 | 0 | 1 | 1 |
arylsulfatase A | 3 | 0 | 0 | 3 |
IDH1 | 1 | 0 | 0 | 1 |
Histone H2A.x | 2 | 0 | 0 | 2 |
glycogen synthase kinase-3 beta isoform 1 | 0 | 0 | 1 | 1 |
mitogen-activated protein kinase 1 | 1 | 0 | 0 | 1 |
flap endonuclease 1 | 2 | 0 | 0 | 2 |
nuclear receptor ROR-gamma isoform 1 | 1 | 0 | 0 | 1 |
peripheral myelin protein 22 | 4 | 0 | 0 | 4 |
survival motor neuron protein isoform d | 2 | 0 | 0 | 2 |
high affinity choline transporter 1 isoform a | 0 | 1 | 0 | 1 |
Sodium/nucleoside cotransporter 1 | 0 | 2 | 0 | 2 |
Calcium dependent protein kinase | 0 | 1 | 0 | 1 |
Mitogen-activated protein kinase kinase kinase 7 | 0 | 0 | 1 | 1 |
Sodium/nucleoside cotransporter 2 | 0 | 2 | 0 | 2 |
Voltage-dependent calcium channel gamma-2 subunit | 1 | 0 | 0 | 1 |
Rap guanine nucleotide exchange factor 3 | 1 | 0 | 0 | 1 |
Purine nucleoside phosphorylase | 0 | 1 | 0 | 1 |
Epidermal growth factor receptor | 0 | 3 | 0 | 3 |
Phosphoglycerate kinase 1 | 0 | 1 | 0 | 1 |
Adenosine deaminase | 0 | 0 | 0 | 1 |
Avidin | 0 | 0 | 1 | 1 |
Adenosine deaminase | 0 | 0 | 0 | 1 |
Glyceraldehyde-3-phosphate dehydrogenase | 0 | 2 | 0 | 2 |
Receptor tyrosine-protein kinase erbB-2 | 0 | 1 | 0 | 1 |
Insulin receptor | 0 | 0 | 0 | 1 |
Phosphoglycerate kinase 2 | 0 | 1 | 0 | 1 |
Heat shock protein HSP 90-alpha | 0 | 1 | 1 | 2 |
Platelet-derived growth factor receptor beta | 0 | 0 | 0 | 1 |
Adenosine receptor A3 | 0 | 2 | 2 | 5 |
Heat shock 70 kDa protein 1A | 0 | 1 | 0 | 1 |
Heat shock cognate 71 kDa protein | 0 | 0 | 1 | 1 |
Fibroblast growth factor receptor 1 | 0 | 0 | 0 | 1 |
Inosine-5'-monophosphate dehydrogenase 2 | 0 | 1 | 0 | 1 |
Endoplasmin | 0 | 1 | 1 | 2 |
Glutamate receptor 2 | 1 | 0 | 0 | 1 |
Inosine-5'-monophosphate dehydrogenase 1 | 0 | 1 | 0 | 1 |
Fibroblast growth factor receptor 2 | 0 | 0 | 0 | 1 |
Fibroblast growth factor receptor 4 | 0 | 0 | 0 | 1 |
Fibroblast growth factor receptor 3 | 0 | 0 | 0 | 1 |
Streptavidin | 0 | 0 | 1 | 1 |
Adenosylhomocysteinase | 0 | 0 | 0 | 1 |
Adenosine receptor A1 | 0 | 1 | 1 | 3 |
Adenosine receptor A3 | 0 | 1 | 0 | 1 |
Adenosine receptor A2a | 0 | 1 | 2 | 4 |
Adenosine receptor A2b | 0 | 0 | 1 | 2 |
Adenosine receptor A2b | 0 | 1 | 1 | 2 |
Adenylate kinase 2, mitochondrial | 0 | 1 | 0 | 1 |
Adenosine receptor A1 | 0 | 2 | 2 | 5 |
Adenosine receptor A2a | 0 | 1 | 1 | 3 |
Adenylate kinase isoenzyme 1 | 0 | 1 | 0 | 1 |
Phosphatidylinositol 4-kinase alpha | 0 | 2 | 0 | 3 |
Adenosine receptor A1 | 0 | 0 | 1 | 1 |
Adenosine kinase | 0 | 0 | 0 | 1 |
Adenosine deaminase | 0 | 0 | 0 | 1 |
Equilibrative nucleoside transporter 2 | 0 | 2 | 0 | 2 |
Phosphatidylinositol 4-kinase type 2-beta | 0 | 2 | 0 | 3 |
Histone-lysine N-methyltransferase, H3 lysine-79 specific | 0 | 1 | 0 | 1 |
Equilibrative nucleoside transporter 1 | 0 | 2 | 0 | 2 |
Phosphatidylinositol 4-kinase type 2-alpha | 0 | 2 | 0 | 3 |
Solute carrier family 28 member 3 | 0 | 2 | 0 | 2 |
Adenosine kinase | 0 | 1 | 0 | 2 |
Phosphatidylinositol 4-kinase beta | 0 | 2 | 0 | 3 |
5-methylthioadenosine/S-adenosylhomocysteine deaminase | 0 | 0 | 0 | 1 |
Adenosine transporter 1 | 0 | 0 | 0 | 1 |
TDP1 protein | 3 | 0 | 0 | 3 |
peroxisome proliferator activated receptor gamma | 3 | 0 | 0 | 3 |
ATP-binding cassette sub-family C member 3 | 0 | 2 | 0 | 2 |
Multidrug resistance-associated protein 4 | 0 | 2 | 0 | 3 |
Bile salt export pump | 0 | 4 | 0 | 4 |
Cellular tumor antigen p53 | 3 | 0 | 0 | 3 |
Thromboxane-A synthase | 0 | 1 | 0 | 1 |
Prostaglandin E2 receptor EP3 subtype | 0 | 1 | 0 | 1 |
Prostaglandin E2 receptor EP4 subtype | 0 | 1 | 1 | 2 |
Prostaglandin E2 receptor EP1 subtype | 0 | 1 | 0 | 1 |
Prostacyclin receptor | 0 | 1 | 1 | 2 |
Nuclear receptor subfamily 4 group A member 2 | 0 | 0 | 1 | 1 |
Solute carrier organic anion transporter family member 2A1 | 0 | 0 | 0 | 1 |
Nuclear receptor subfamily 4 group A member 2 | 0 | 0 | 1 | 1 |
Nuclear receptor subfamily 4 group A member 2 | 0 | 0 | 1 | 1 |
Prostaglandin E2 receptor EP2 subtype | 0 | 1 | 1 | 2 |
Canalicular multispecific organic anion transporter 1 | 0 | 2 | 0 | 2 |
Solute carrier organic anion transporter family member 2A1 | 0 | 0 | 0 | 1 |
Solute carrier organic anion transporter family member 2B1 | 0 | 1 | 0 | 1 |
Solute carrier organic anion transporter family member 3A1 | 0 | 0 | 0 | 1 |
Cereblon isoform 4 | 0 | 2 | 0 | 2 |
GLI family zinc finger 3 | 3 | 0 | 0 | 3 |
retinoic acid nuclear receptor alpha variant 1 | 2 | 0 | 0 | 2 |
vitamin D (1,25- dihydroxyvitamin D3) receptor | 4 | 0 | 0 | 4 |
nuclear factor erythroid 2-related factor 2 isoform 1 | 1 | 0 | 0 | 1 |
Insulin-like growth factor-binding protein 5 | 0 | 0 | 1 | 1 |
Choline O-acetyltransferase | 0 | 1 | 0 | 1 |
Protein cereblon | 0 | 2 | 0 | 2 |
dopamine D1 receptor | 2 | 0 | 0 | 2 |
glp-1 receptor, partial | 2 | 0 | 0 | 2 |
thioredoxin reductase | 4 | 0 | 0 | 4 |
phosphopantetheinyl transferase | 2 | 0 | 0 | 2 |
Fumarate hydratase | 1 | 0 | 0 | 1 |
GALC protein | 1 | 0 | 0 | 1 |
GLS protein | 2 | 0 | 0 | 2 |
estrogen receptor 2 (ER beta) | 1 | 0 | 0 | 1 |
cytochrome P450 family 3 subfamily A polypeptide 4 | 2 | 0 | 0 | 2 |
EWS/FLI fusion protein | 2 | 0 | 0 | 2 |
cytochrome P450 2D6 | 2 | 0 | 0 | 2 |
polyprotein | 1 | 0 | 0 | 1 |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 1 | 0 | 0 | 1 |
aryl hydrocarbon receptor | 2 | 0 | 0 | 2 |
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | 1 | 0 | 0 | 1 |
activating transcription factor 6 | 2 | 0 | 0 | 2 |
D(1A) dopamine receptor | 1 | 0 | 0 | 1 |
mu-type opioid receptor isoform MOR-1 | 0 | 0 | 1 | 1 |
chromobox protein homolog 1 | 2 | 0 | 0 | 2 |
huntingtin isoform 2 | 1 | 0 | 0 | 1 |
geminin | 4 | 0 | 0 | 4 |
lamin isoform A-delta10 | 2 | 0 | 0 | 2 |
5-hydroxytryptamine receptor 2A | 0 | 0 | 1 | 1 |
Solute carrier family 22 member 1 | 0 | 1 | 0 | 1 |
Carbonic anhydrase 12 | 0 | 2 | 0 | 3 |
Carbonic anhydrase 1 | 0 | 3 | 0 | 4 |
Carbonic anhydrase 2 | 0 | 3 | 0 | 4 |
Tyrosine-protein kinase Lck | 0 | 2 | 0 | 2 |
Tyrosine-protein kinase Fyn | 0 | 2 | 0 | 2 |
Carbonic anhydrase 3 | 0 | 2 | 0 | 3 |
Beta-2 adrenergic receptor | 0 | 2 | 0 | 2 |
Aldo-keto reductase family 1 member B1 | 0 | 2 | 0 | 2 |
Beta-1 adrenergic receptor | 0 | 2 | 0 | 2 |
Polyunsaturated fatty acid lipoxygenase ALOX15 | 0 | 2 | 0 | 2 |
POU domain, class 2, transcription factor 1 | 0 | 0 | 0 | 1 |
Alpha-2B adrenergic receptor | 0 | 2 | 0 | 2 |
Carbonic anhydrase 4 | 0 | 2 | 0 | 3 |
Carbonic anhydrase 6 | 0 | 2 | 0 | 3 |
Sodium-dependent noradrenaline transporter | 0 | 2 | 0 | 2 |
Alpha-1D adrenergic receptor | 0 | 2 | 0 | 2 |
Sodium-dependent serotonin transporter | 0 | 2 | 0 | 2 |
Carbonic anhydrase 5A, mitochondrial | 0 | 2 | 0 | 3 |
D(3) dopamine receptor | 0 | 2 | 0 | 2 |
Carbonic anhydrase 7 | 0 | 2 | 0 | 3 |
Spike glycoprotein | 1 | 0 | 0 | 1 |
Sodium-dependent dopamine transporter | 0 | 2 | 0 | 2 |
Carbonic anhydrase 9 | 0 | 2 | 0 | 3 |
Carbonic anhydrase 13 | 0 | 1 | 0 | 1 |
Ataxin-2 | 2 | 0 | 0 | 2 |
Sigma non-opioid intracellular receptor 1 | 0 | 2 | 0 | 2 |
Carbonic anhydrase 15 | 0 | 2 | 0 | 3 |
Carbonic anhydrase 14 | 0 | 2 | 0 | 3 |
Carbonic anhydrase 5B, mitochondrial | 0 | 2 | 0 | 3 |
Chain A, TYROSYL-DNA PHOSPHODIESTERASE | 1 | 0 | 0 | 1 |
Chain A, HADH2 protein | 1 | 0 | 0 | 1 |
Chain B, HADH2 protein | 1 | 0 | 0 | 1 |
Chain A, JmjC domain-containing histone demethylation protein 3A | 1 | 0 | 0 | 1 |
Chain A, 2-oxoglutarate Oxygenase | 3 | 0 | 0 | 3 |
Chain A, ATP-DEPENDENT DNA HELICASE Q1 | 1 | 0 | 0 | 1 |
Luciferase | 1 | 0 | 0 | 1 |
15-lipoxygenase, partial | 1 | 0 | 0 | 1 |
WRN | 1 | 0 | 0 | 1 |
integrase, partial | 0 | 1 | 0 | 1 |
lens epithelium-derived growth factor p75 | 0 | 1 | 0 | 1 |
apical membrane antigen 1, AMA1 | 1 | 0 | 0 | 1 |
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 1 | 0 | 0 | 1 |
pyruvate kinase | 1 | 0 | 0 | 1 |
euchromatic histone-lysine N-methyltransferase 2 | 1 | 0 | 0 | 1 |
Bloom syndrome protein isoform 1 | 2 | 0 | 0 | 2 |
hexokinase-4 isoform 1 | 1 | 0 | 0 | 1 |
atrial natriuretic peptide receptor 1 precursor | 1 | 0 | 0 | 1 |
glucokinase regulatory protein | 1 | 0 | 0 | 1 |
importin subunit beta-1 isoform 1 | 1 | 0 | 0 | 1 |
ubiquitin carboxyl-terminal hydrolase 2 isoform a | 1 | 0 | 0 | 1 |
snurportin-1 | 1 | 0 | 0 | 1 |
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 2 | 0 | 0 | 2 |
DNA polymerase eta isoform 1 | 1 | 0 | 0 | 1 |
DNA polymerase iota isoform a (long) | 1 | 0 | 0 | 1 |
DNA polymerase kappa isoform 1 | 1 | 0 | 0 | 1 |
M-phase phosphoprotein 8 | 1 | 0 | 0 | 1 |
muscarinic acetylcholine receptor M1 | 2 | 0 | 0 | 2 |
Polyphenol oxidase 2 | 0 | 1 | 0 | 3 |
Plasma kallikrein | 0 | 0 | 0 | 1 |
Tyrosinase | 0 | 1 | 0 | 1 |
Glutamate receptor ionotropic, NMDA 1 | 0 | 0 | 0 | 1 |
Carbonic anhydrase | 0 | 0 | 0 | 1 |
Solute carrier family 15 member 1 | 0 | 1 | 0 | 1 |
Carbonic anhydrase | 0 | 0 | 0 | 1 |
Glutamate receptor ionotropic, NMDA 2A | 0 | 0 | 0 | 1 |
Glutamate receptor ionotropic, NMDA 2B | 0 | 0 | 0 | 1 |
Glutamate receptor ionotropic, NMDA 2C | 0 | 0 | 0 | 1 |
Large neutral amino acids transporter small subunit 1 | 0 | 1 | 0 | 1 |
SLC16A10 protein | 0 | 0 | 0 | 1 |
Carbonic anhydrase | 0 | 0 | 0 | 1 |
Carbonic anhydrase-like protein, putative | 0 | 0 | 0 | 1 |
Carbonic anhydrase | 0 | 0 | 0 | 1 |
Carbonic anhydrase | 0 | 0 | 0 | 1 |
Glutamate receptor ionotropic, NMDA 2D | 0 | 0 | 0 | 1 |
Carbonic anhydrase | 0 | 0 | 0 | 1 |
Glutamate receptor ionotropic, NMDA 3B | 0 | 0 | 0 | 1 |
Monocarboxylate transporter 10 | 0 | 0 | 0 | 1 |
Carbonic anhydrase 13 | 0 | 1 | 0 | 2 |
Glutamate receptor ionotropic, NMDA 3A | 0 | 0 | 0 | 1 |
phosphoglycerate kinase | 1 | 0 | 0 | 1 |
ATP-dependent phosphofructokinase | 2 | 0 | 0 | 2 |
Chain A, Beta-lactamase | 1 | 0 | 0 | 1 |
acetylcholinesterase | 1 | 0 | 0 | 1 |
RAR-related orphan receptor gamma | 1 | 0 | 0 | 1 |
SMAD family member 2 | 1 | 0 | 0 | 1 |
SMAD family member 3 | 1 | 0 | 0 | 1 |
thyroid stimulating hormone receptor | 1 | 0 | 0 | 1 |
progesterone receptor | 1 | 0 | 0 | 1 |
estrogen-related nuclear receptor alpha | 1 | 0 | 0 | 1 |
pregnane X nuclear receptor | 1 | 0 | 0 | 1 |
G | 1 | 0 | 0 | 1 |
peroxisome proliferator-activated receptor delta | 1 | 0 | 0 | 1 |
Phosphodiesterase | 0 | 1 | 0 | 1 |
thyroid stimulating hormone receptor | 1 | 0 | 0 | 1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | 1 | 0 | 0 | 1 |
cytochrome P450 2C19 precursor | 1 | 0 | 0 | 1 |
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | 2 | 0 | 0 | 2 |
thyroid hormone receptor beta isoform 2 | 1 | 0 | 0 | 1 |
Vpr | 1 | 0 | 0 | 1 |
cGMP-dependent 3',5'-cyclic phosphodiesterase | 0 | 1 | 0 | 1 |
Aurora kinase A | 0 | 1 | 0 | 1 |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | 0 | 1 | 0 | 1 |
cGMP-specific 3',5'-cyclic phosphodiesterase | 0 | 1 | 0 | 1 |
3',5'-cyclic-AMP phosphodiesterase | 0 | 1 | 0 | 1 |
Interferon beta | 1 | 0 | 0 | 1 |
HLA class I histocompatibility antigen, B alpha chain | 1 | 0 | 0 | 1 |
Prostaglandin G/H synthase 1 | 0 | 2 | 0 | 2 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 0 | 1 | 0 | 1 |
Dual specificity protein kinase TTK | 0 | 1 | 0 | 1 |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | 0 | 1 | 0 | 1 |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | 0 | 1 | 0 | 1 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 0 | 1 | 0 | 1 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C | 0 | 1 | 0 | 1 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 0 | 1 | 0 | 1 |
cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 0 | 2 | 0 | 2 |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | 0 | 1 | 0 | 1 |
cGMP-inhibited 3',5'-cyclic phosphodiesterase A | 0 | 2 | 0 | 2 |
cGMP-specific 3',5'-cyclic phosphodiesterase | 0 | 1 | 0 | 1 |
Inositol hexakisphosphate kinase 1 | 1 | 0 | 0 | 1 |
Aurora kinase B | 0 | 1 | 0 | 1 |
ATPase family AAA domain-containing protein 5 | 1 | 0 | 0 | 1 |
Inner centromere protein | 0 | 1 | 0 | 1 |
Phosphodiesterase | 0 | 1 | 0 | 1 |
cytochrome P450 2C9, partial | 1 | 0 | 0 | 1 |
chaperonin-containing TCP-1 beta subunit homolog | 1 | 0 | 0 | 1 |
aldehyde dehydrogenase 1 family, member A1 | 1 | 0 | 0 | 1 |
histone acetyltransferase KAT2A isoform 1 | 1 | 0 | 0 | 1 |
Estrogen receptor beta | 0 | 0 | 0 | 1 |
Inhibitor of nuclear factor kappa-B kinase subunit beta | 0 | 0 | 0 | 1 |
Solute carrier family 22 member 6 | 0 | 1 | 0 | 1 |
5'-AMP-activated protein kinase subunit beta-2 | 0 | 0 | 0 | 1 |
Bile salt export pump | 0 | 1 | 0 | 1 |
Albumin | 0 | 1 | 0 | 1 |
Polymerase acidic protein | 0 | 0 | 1 | 1 |
Stromelysin-1 | 0 | 0 | 1 | 1 |
Tyrosine-protein phosphatase YopH | 0 | 1 | 0 | 1 |
High mobility group protein B1 | 0 | 0 | 1 | 1 |
Aldo-keto reductase family 1 member B1 | 0 | 1 | 0 | 1 |
Prolyl 4-hydroxylase subunit alpha-1 | 0 | 1 | 0 | 1 |
Tyrosine-protein phosphatase non-receptor type 1 | 0 | 1 | 0 | 3 |
Estrogen receptor | 0 | 0 | 0 | 1 |
Acetylcholinesterase | 0 | 1 | 0 | 1 |
Cystathionine gamma-lyase | 0 | 1 | 0 | 1 |
Prostaglandin G/H synthase 2 | 0 | 1 | 0 | 1 |
5'-AMP-activated protein kinase subunit gamma-1 | 0 | 0 | 0 | 1 |
5'-AMP-activated protein kinase catalytic subunit alpha-2 | 0 | 0 | 0 | 1 |
Xanthine dehydrogenase/oxidase | 0 | 1 | 0 | 1 |
5'-AMP-activated protein kinase catalytic subunit alpha-1 | 0 | 0 | 0 | 1 |
Carbonic anhydrase | 0 | 1 | 0 | 1 |
Solute carrier family 22 member 6 | 0 | 1 | 0 | 1 |
Solute carrier family 22 member 7 | 0 | 0 | 0 | 1 |
Nicotinate phosphoribosyltransferase | 0 | 1 | 0 | 1 |
Solute carrier family 22 member 20 | 0 | 1 | 0 | 1 |
Solute carrier family 22 member 8 | 0 | 1 | 0 | 1 |
Solute carrier family 22 member 6 | 0 | 1 | 0 | 1 |
Ubiquitin-like domain-containing CTD phosphatase 1 | 0 | 1 | 0 | 1 |
5'-AMP-activated protein kinase subunit gamma-3 | 0 | 0 | 0 | 1 |
5'-AMP-activated protein kinase subunit gamma-2 | 0 | 0 | 0 | 1 |
5'-AMP-activated protein kinase subunit beta-1 | 0 | 0 | 0 | 1 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |