Page last updated: 2024-09-27

Vein Of Galen Malformation

Congenital arteriovenous malformation involving the VEIN OF GALEN, a large deep vein at the base of the brain. The rush of arterial blood directly into the vein of Galen, without passing through the CAPILLARIES, can overwhelm the heart and lead to CONGESTIVE HEART FAILURE.

Synonyms(2)

Synonym
Vein of Galen Malformations
Vein Of Galen Malformation

Research Excerpts

Overview

ExcerptReference
"Vein of Galen malformations are congenital high-flow vascular malformations that often present with heart failure, hydrocephalus, developmental delay, and intracranial hemorrhage."( Scoville, JP; Taussky, P; Yoon, NK, 2018)

Research

Studies (12)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's1 (8.33)18.1394
2010's9 (75.00)28.8240
2020's2 (16.67)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
dimethyl sulfoxide0medium21
milrinone0low10
levodopa0low10
enbucrilate0medium21
dobutamine0low10
adenosine0low20
nsc-1727550low10
rocuronium0low10
alprostadil0low10
cardiovascular agents0low10

Protein Targets (292)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
AR protein5005
signal transducer and activator of transcription 6, interleukin-4 induced1001
regulator of G-protein signaling 42002
glucocorticoid receptor [Homo sapiens]4004
retinoid X nuclear receptor alpha4004
estrogen nuclear receptor alpha6006
NPYLR7B0011
arylsulfatase A3003
IDH11001
Histone H2A.x2002
glycogen synthase kinase-3 beta isoform 10011
mitogen-activated protein kinase 11001
flap endonuclease 12002
nuclear receptor ROR-gamma isoform 11001
peripheral myelin protein 224004
survival motor neuron protein isoform d2002
high affinity choline transporter 1 isoform a0101
Sodium/nucleoside cotransporter 10202
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 70011
Sodium/nucleoside cotransporter 20202
Voltage-dependent calcium channel gamma-2 subunit1001
Rap guanine nucleotide exchange factor 31001
Purine nucleoside phosphorylase0101
Epidermal growth factor receptor0303
Phosphoglycerate kinase 1 0101
Adenosine deaminase0001
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0202
Receptor tyrosine-protein kinase erbB-20101
Insulin receptor0001
Phosphoglycerate kinase 20101
Heat shock protein HSP 90-alpha0112
Platelet-derived growth factor receptor beta0001
Adenosine receptor A30225
Heat shock 70 kDa protein 1A 0101
Heat shock cognate 71 kDa protein0011
Fibroblast growth factor receptor 10001
Inosine-5'-monophosphate dehydrogenase 20101
Endoplasmin0112
Glutamate receptor 21001
Inosine-5'-monophosphate dehydrogenase 1 0101
Fibroblast growth factor receptor 20001
Fibroblast growth factor receptor 40001
Fibroblast growth factor receptor 30001
Streptavidin0011
Adenosylhomocysteinase0001
Adenosine receptor A10113
Adenosine receptor A30101
Adenosine receptor A2a0124
Adenosine receptor A2b0012
Adenosine receptor A2b0112
Adenylate kinase 2, mitochondrial0101
Adenosine receptor A10225
Adenosine receptor A2a0113
Adenylate kinase isoenzyme 1 0101
Phosphatidylinositol 4-kinase alpha0203
Adenosine receptor A10011
Adenosine kinase0001
Adenosine deaminase 0001
Equilibrative nucleoside transporter 20202
Phosphatidylinositol 4-kinase type 2-beta0203
Histone-lysine N-methyltransferase, H3 lysine-79 specific0101
Equilibrative nucleoside transporter 10202
Phosphatidylinositol 4-kinase type 2-alpha0203
Solute carrier family 28 member 30202
Adenosine kinase0102
Phosphatidylinositol 4-kinase beta0203
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Adenosine transporter 10001
TDP1 protein3003
peroxisome proliferator activated receptor gamma3003
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40203
Bile salt export pump0404
Cellular tumor antigen p533003
Thromboxane-A synthase 0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP1 subtype0101
Prostacyclin receptor0112
Nuclear receptor subfamily 4 group A member 20011
Solute carrier organic anion transporter family member 2A10001
Nuclear receptor subfamily 4 group A member 20011
Nuclear receptor subfamily 4 group A member 20011
Prostaglandin E2 receptor EP2 subtype0112
Canalicular multispecific organic anion transporter 10202
Solute carrier organic anion transporter family member 2A10001
Solute carrier organic anion transporter family member 2B10101
Solute carrier organic anion transporter family member 3A10001
Cereblon isoform 40202
GLI family zinc finger 33003
retinoic acid nuclear receptor alpha variant 12002
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
nuclear factor erythroid 2-related factor 2 isoform 11001
Insulin-like growth factor-binding protein 50011
Choline O-acetyltransferase 0101
Protein cereblon0202
dopamine D1 receptor2002
glp-1 receptor, partial2002
thioredoxin reductase4004
phosphopantetheinyl transferase2002
Fumarate hydratase1001
GALC protein1001
GLS protein2002
estrogen receptor 2 (ER beta)1001
cytochrome P450 family 3 subfamily A polypeptide 42002
EWS/FLI fusion protein2002
cytochrome P450 2D62002
polyprotein1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
activating transcription factor 62002
D(1A) dopamine receptor1001
mu-type opioid receptor isoform MOR-10011
chromobox protein homolog 12002
huntingtin isoform 21001
geminin4004
lamin isoform A-delta102002
5-hydroxytryptamine receptor 2A0011
Solute carrier family 22 member 1 0101
Carbonic anhydrase 120203
Carbonic anhydrase 10304
Carbonic anhydrase 20304
Tyrosine-protein kinase Lck0202
Tyrosine-protein kinase Fyn0202
Carbonic anhydrase 30203
Beta-2 adrenergic receptor0202
Aldo-keto reductase family 1 member B10202
Beta-1 adrenergic receptor0202
Polyunsaturated fatty acid lipoxygenase ALOX150202
POU domain, class 2, transcription factor 10001
Alpha-2B adrenergic receptor0202
Carbonic anhydrase 40203
Carbonic anhydrase 60203
Sodium-dependent noradrenaline transporter 0202
Alpha-1D adrenergic receptor0202
Sodium-dependent serotonin transporter0202
Carbonic anhydrase 5A, mitochondrial0203
D(3) dopamine receptor0202
Carbonic anhydrase 70203
Spike glycoprotein1001
Sodium-dependent dopamine transporter 0202
Carbonic anhydrase 90203
Carbonic anhydrase 130101
Ataxin-22002
Sigma non-opioid intracellular receptor 10202
Carbonic anhydrase 150203
Carbonic anhydrase 140203
Carbonic anhydrase 5B, mitochondrial0203
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Luciferase1001
15-lipoxygenase, partial1001
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
apical membrane antigen 1, AMA11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
pyruvate kinase1001
euchromatic histone-lysine N-methyltransferase 21001
Bloom syndrome protein isoform 12002
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
importin subunit beta-1 isoform 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
muscarinic acetylcholine receptor M12002
Polyphenol oxidase 20103
Plasma kallikrein0001
Tyrosinase0101
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Solute carrier family 15 member 10101
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Carbonic anhydrase 130102
Glutamate receptor ionotropic, NMDA 3A0001
phosphoglycerate kinase1001
ATP-dependent phosphofructokinase2002
Chain A, Beta-lactamase1001
acetylcholinesterase1001
RAR-related orphan receptor gamma1001
SMAD family member 21001
SMAD family member 31001
thyroid stimulating hormone receptor1001
progesterone receptor1001
estrogen-related nuclear receptor alpha1001
pregnane X nuclear receptor1001
G1001
peroxisome proliferator-activated receptor delta1001
Phosphodiesterase 0101
thyroid stimulating hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
cytochrome P450 2C19 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
thyroid hormone receptor beta isoform 21001
Vpr1001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Aurora kinase A0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Prostaglandin G/H synthase 10202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Dual specificity protein kinase TTK0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0202
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Inositol hexakisphosphate kinase 11001
Aurora kinase B0101
ATPase family AAA domain-containing protein 51001
Inner centromere protein0101
Phosphodiesterase 0101
cytochrome P450 2C9, partial1001
chaperonin-containing TCP-1 beta subunit homolog1001
aldehyde dehydrogenase 1 family, member A11001
histone acetyltransferase KAT2A isoform 11001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Albumin0101
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Cystathionine gamma-lyase0101
Prostaglandin G/H synthase 20101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]