Page last updated: 2024-09-27

Squamous Intraepithelial Lesions

A cytological test finding that shows abnormal lesions of SQUAMOUS EPITHELIAL cells.

Synonyms(1)

Synonym
Squamous Intraepithelial Lesions

Research

Studies (33)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's7 (21.21)28.8240
2020's26 (78.79)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aminolevulinic acid0medium112
lactic acid0low10
iodine0low10
nitrous oxide0low10
mitomycin0low20
hematoxylin0low10
malondialdehyde0low10
eosine yellowish-(ys)0low10
fomesafen0low10
cidofovir anhydrous0low10
5-aminolevulinic acid hexyl ester0medium11
phosphatidylcholines0low10
kx-010low10
piperidines0low10

Protein Targets (514)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase1001
bromodomain adjacent to zinc finger domain 2B2002
geminin5005
Gamma-aminobutyric acid receptor subunit rho-10101
Glutamate receptor 10101
Glutamate receptor 20101
Glutamate receptor 30101
Glutamate receptor ionotropic, kainate 30101
Solute carrier family 15 member 10101
Glutamate receptor 40101
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
Thymidine kinase 0101
estrogen nuclear receptor alpha7007
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Solute carrier family 22 member 60001
Bile salt export pump0303
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Thymidine kinase0001
Solute carrier family 22 member 60102
Canalicular multispecific organic anion transporter 10303
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase4004
interleukin 81001
endonuclease IV1001
acetylcholinesterase3003
glp-1 receptor, partial1001
Skn7p0001
thioredoxin reductase2002
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma4004
ATAD5 protein, partial1001
TDP1 protein4004
GLI family zinc finger 33003
Microtubule-associated protein tau2002
Thrombopoietin1001
AR protein4004
aldehyde dehydrogenase 1 family, member A12002
thyroid stimulating hormone receptor1001
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor4004
EWS/FLI fusion protein4004
nonstructural protein 11001
glucocorticoid receptor [Homo sapiens]2002
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha5005
farnesoid X nuclear receptor2002
pregnane X nuclear receptor4004
67.9K protein3003
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma4004
arylsulfatase A1001
IDH11001
euchromatic histone-lysine N-methyltransferase 22002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x3003
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
chromobox protein homolog 12002
nuclear factor erythroid 2-related factor 2 isoform 23003
thyroid hormone receptor beta isoform 22002
huntingtin isoform 21001
flap endonuclease 12002
serine/threonine-protein kinase mTOR isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 14004
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Vpr1001
peripheral myelin protein 222002
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 11001
lamin isoform A-delta102002
Voltage-dependent calcium channel gamma-2 subunit3003
Solute carrier family 22 member 80001
Epidermal growth factor receptor0112
Cellular tumor antigen p533003
Amyloid-beta precursor protein1001
Thymidylate synthase0101
Aromatase0101
Glutamate receptor 23003
ATPase family AAA domain-containing protein 51001
Ataxin-21001
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
ATP-dependent phosphofructokinase2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain E, Fibrin beta chain0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, RNA-directed RNA polymerase NS50101
15-lipoxygenase, partial1001
WRN1001
Mcl-10101
phosphopantetheinyl transferase1001
MPI protein0101
USP1 protein, partial1001
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)0001
PPM1D protein2002
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase1001
apical membrane antigen 1, AMA11001
hypothetical protein, conserved1001
regulator of G-protein signaling 41001
cytochrome P450 family 3 subfamily A polypeptide 44004
G2002
glucocerebrosidase1001
luciferase1001
pyruvate kinase1001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
CDK50001
serine-protein kinase ATM isoform a1001
lysosomal alpha-glucosidase preproprotein1001
major prion protein preproprotein Prp precursor0101
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0011
cellular tumor antigen p53 isoform a2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
vitamin D3 receptor isoform VDRA1001
glucose-6-phosphate 1-dehydrogenase isoform b0101
intestinal alkaline phosphatase precursor0011
DNA polymerase beta2002
mitogen-activated protein kinase 11001
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)2002
nuclear receptor ROR-gamma isoform 11001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
DNA polymerase kappa isoform 11001
Vif0101
Tat0101
cytochrome P450 3A4 isoform 11001
histone acetyltransferase KAT2A isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
alkaline phosphatase, germ cell type preproprotein0011
endoribonuclease toxin MazF0011
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Gamma-aminobutyric acid receptor subunit pi1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Rap guanine nucleotide exchange factor 31001
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Integrin beta-32002
Integrin alpha-IIb2002
Pyruvate kinase PKM0101
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Endothelin receptor type B1001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Endothelin-1 receptor1001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Histamine H2 receptor1001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Inositol monophosphatase 11001
GABA theta subunit1001
Inositol hexakisphosphate kinase 12002
Gamma-aminobutyric acid receptor subunit epsilon1001
cytochrome P450 2C9, partial2002
phosphoglycerate kinase1001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
large T antigen0101
cytochrome P450 2D63003
aryl hydrocarbon receptor3003
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Adenosine receptor A2a0202
7,8-dihydro-8-oxoguanine triphosphatase0101
Toll-like receptor 80011
Toll-like receptor 70011
activating transcription factor 61001
histone deacetylase 9 isoform 31001
Fumarate hydratase2002
polyprotein2002
Bone morphogenetic protein receptor type-1B0011
Membrane-associated progesterone receptor component 10011
Serine/threonine-protein kinase PLK40011
ATP-dependent RNA helicase DDX3X0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase Chk10011
Aurora kinase A0011
Cyclin-G-associated kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Receptor-interacting serine/threonine-protein kinase 20011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
Dynamin-like 120 kDa protein, mitochondrial0011
Tyrosine-protein kinase JAK20011
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30011
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
Tyrosine-protein kinase ABL10213
Tyrosine-protein kinase ABL10101
Tubulin beta-4A chain0011
High affinity nerve growth factor receptor0011
ADP/ATP translocase 20011
Protein kinase C beta type0011
Insulin receptor0011
Tyrosine-protein kinase Lck0011
Tyrosine-protein kinase Fyn0011
Cyclin-dependent kinase 10011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Tubulin beta chain0011
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0011
Tyrosine-protein kinase Lyn0112
Proto-oncogene tyrosine-protein kinase receptor Ret0011
Insulin-like growth factor 1 receptor0011
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0011
Tyrosine-protein kinase HCK0011
Platelet-derived growth factor receptor beta0011
Tyrosine-protein kinase Fgr0011
Tubulin alpha-3C chain0011
Serine/threonine-protein kinase A-Raf0011
Glycogen phosphorylase, brain form0011
Breakpoint cluster region protein0213
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10011
DNA topoisomerase 2-alpha0011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
Proto-oncogene tyrosine-protein kinase Src0213
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Ribosyldihydronicotinamide dehydrogenase [quinone]0011
Tyrosine-protein kinase Fer0011
Protein kinase C alpha type0011
cAMP-dependent protein kinase catalytic subunit alpha0011
General transcription and DNA repair factor IIH helicase subunit XPD0011
Casein kinase II subunit alpha'0011
Ras-related protein Rab-6A0011
Ephrin type-A receptor 10011
Multifunctional protein ADE20011
cAMP-dependent protein kinase catalytic subunit beta0011
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Cyclin-dependent kinase 20011
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Mitogen-activated protein kinase 3 0011
MAP/microtubule affinity-regulating kinase 30011
Deoxycytidine kinase0011
Mitogen-activated protein kinase 10011
Ephrin type-A receptor 20011
Ephrin type-B receptor 20011
Non-receptor tyrosine-protein kinase TYK20011
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0011
RAC-beta serine/threonine-protein kinase0011
DNA replication licensing factor MCM40011
Myosin-100011
Dual specificity mitogen-activated protein kinase kinase 20011
Receptor-type tyrosine-protein kinase FLT30011
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0011
Glycine--tRNA ligase0011
Protein kinase C iota type0011
Exosome RNA helicase MTR40011
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0011
26S proteasome regulatory subunit 6B0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 40011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0011
Casein kinase I isoform delta0011
MAP kinase-activated protein kinase 20011
Elongation factor Tu, mitochondrial0011
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Interleukin-1 receptor-associated kinase 10011
Ribosomal protein S6 kinase alpha-30011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10011
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
5'-AMP-activated protein kinase subunit gamma-10011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Adenosine kinase0011
Ras-related protein Rab-100011
Actin-related protein 30011
Actin-related protein 20011
GTP-binding nuclear protein Ran0011
Tubulin alpha-1B chain0011
Tubulin alpha-4A chain0011
Tubulin beta-4B chain0011
Casein kinase I isoform gamma-20011
Cyclin-dependent kinase 30011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
ATP-dependent 6-phosphofructokinase, platelet type0011
Dual specificity mitogen-activated protein kinase kinase 10011
DNA topoisomerase 2-beta0011
Protein kinase C theta type0011
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10011
Protein kinase C zeta type0011
Protein kinase C delta type0011
Tyrosine-protein kinase BTK0011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Mitogen-activated protein kinase kinase kinase kinase 20011
Serine/threonine-protein kinase 40011
5'-AMP-activated protein kinase catalytic subunit alpha-10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
Integrin-linked protein kinase0011
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Tubulin beta-3 chain0011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
Tubulin beta-2A chain0011
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Serine/threonine-protein kinase 380011
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10011
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Mitogen-activated protein kinase 140011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
Discoidin domain-containing receptor 20011
AP2-associated protein kinase 10011
Myosin light chain kinase 30011
Uncharacterized aarF domain-containing protein kinase 50011
Tubulin beta-8 chain0011
Putative heat shock protein HSP 90-beta 20011
Rab-like protein 30011
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Breakpoint cluster region protein0101
Tubulin alpha-3E chain0011
Serine/threonine-protein kinase ULK30011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Tubulin alpha-1A chain0011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
ATP-dependent RNA helicase DDX420011
Mitogen-activated protein kinase kinase kinase kinase 30011
MAP kinase-activated protein kinase 50011
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0011
Misshapen-like kinase 10011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
Serine/threonine-protein kinase Nek70011
ATP-dependent RNA helicase DDX10011
Mitogen-activated protein kinase kinase kinase kinase 10011
Aurora kinase B0011
MAP/microtubule affinity-regulating kinase 40011
Serine/threonine-protein kinase Nek10011
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
Dual specificity testis-specific protein kinase 20011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0011
Mitogen-activated protein kinase kinase kinase 50011
Mitogen-activated protein kinase kinase kinase 30011
Tubulin alpha-1C chain0011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Tubulin beta-6 chain0011
Tubulin beta-2B chain0011
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
Tubulin beta-1 chain0011
dCTP pyrophosphatase 10011
Dual specificity protein kinase CLK40011
Casein kinase I isoform gamma-10011
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Obg-like ATPase 10011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase pim-20011
Serine/threonine-protein kinase 260011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
5'-AMP-activated protein kinase subunit gamma-20011
Serine/threonine-protein kinase TBK10011
Septin-90011
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase TAO20011
Long-chain-fatty-acid--CoA ligase 50011
Serine/threonine-protein kinase ICK0011
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase 38-like0011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
thyroid stimulating hormone receptor1001
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
nuclear receptor subfamily 1, group I, member 21001
Indoleamine 2,3-dioxygenase 10101
Spike glycoprotein1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]