aminolevulinic acid has been researched along with Squamous Intraepithelial Lesions in 11 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Squamous Intraepithelial Lesions: A cytological test finding that shows abnormal lesions of SQUAMOUS EPITHELIAL cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser pretreatment (Laser+ALA-PDT) on patients with cervical high-grade squamous intraepithelial lesions (HSILs)." | 8.31 | Effect of topical 5-aminolevulinic acid photodynamic therapy versus therapy combined with CO2 laser pretreatment for patients with cervical high-grade squamous intraepithelial lesions. ( Feng, C; Gu, L; Hong, Z; Qiu, L; Wang, L; Wei, Y; Wu, D, 2023) |
| "To evaluate the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of high-grade squamous intraepithelial lesions of the cervix (HSIL)." | 8.12 | Topical 5-aminolevulinic acid photodynamic therapy for cervical high-grade squamous intraepithelial lesions. ( Chen, J; Hu, Y; Li, Y; Ma, L; Teng, Y; Xu, Y, 2022) |
| "Patients with cervical LSIL and HPV infection were divided into 3 treatment groups based on their own choice." | 7.30 | The effect of aminolevulinic acid hydrochloride topical powder photodynamic therapy versus nocardia rubra cell wall skeleton and observers group in the treatment of cervical low-grade squamous intraepithelial lesions with human papillomavirus infection: A ( Gong, H; Jiang, S; Nan, X; Pan, X; Tang, L; Zhang, J, 2023) |
| "To evaluate the effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser pretreatment (Laser+ALA-PDT) on patients with cervical high-grade squamous intraepithelial lesions (HSILs)." | 5.91 | Effect of topical 5-aminolevulinic acid photodynamic therapy versus therapy combined with CO2 laser pretreatment for patients with cervical high-grade squamous intraepithelial lesions. ( Feng, C; Gu, L; Hong, Z; Qiu, L; Wang, L; Wei, Y; Wu, D, 2023) |
| "Cervical high-grade squamous intraepithelial lesions (HSIL), as pre-cancerous lesions, have a 5% chance of progressing to invasive cancer." | 5.72 | The effect of high-risk HPV E6/E7 mRNA on the efficacy of topical photodynamic therapy with 5-aminolevulinic acid for cervical high-grade squamous intraepithelial lesions. ( Cao, L; Qin, L; Shen, Y; Su, Y; Tang, Y; Wang, B; Wang, L; Zhang, L; Zhang, M; Zhang, T; Zhang, Y; Zhou, Y, 2022) |
| "High-risk HPV infection is the main cause of cervical cancer and pre-cancerous lesions." | 5.62 | The effect of local photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical low-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study. ( Cheng, M; Di, W; Gu, L; Hong, Z; Qiu, L, 2021) |
| "Progression to high-grade squamous intraepithelial lesion warrants intervention." | 5.62 | The effect of local photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical low-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study. ( Cheng, M; Di, W; Gu, L; Hong, Z; Qiu, L, 2021) |
| "To evaluate the effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser pretreatment (Laser+ALA-PDT) on patients with cervical high-grade squamous intraepithelial lesions (HSILs)." | 4.31 | Effect of topical 5-aminolevulinic acid photodynamic therapy versus therapy combined with CO2 laser pretreatment for patients with cervical high-grade squamous intraepithelial lesions. ( Feng, C; Gu, L; Hong, Z; Qiu, L; Wang, L; Wei, Y; Wu, D, 2023) |
| "To evaluate the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of high-grade squamous intraepithelial lesions of the cervix (HSIL)." | 4.12 | Topical 5-aminolevulinic acid photodynamic therapy for cervical high-grade squamous intraepithelial lesions. ( Chen, J; Hu, Y; Li, Y; Ma, L; Teng, Y; Xu, Y, 2022) |
| "Patients with cervical LSIL and HPV infection were divided into 3 treatment groups based on their own choice." | 3.30 | The effect of aminolevulinic acid hydrochloride topical powder photodynamic therapy versus nocardia rubra cell wall skeleton and observers group in the treatment of cervical low-grade squamous intraepithelial lesions with human papillomavirus infection: A ( Gong, H; Jiang, S; Nan, X; Pan, X; Tang, L; Zhang, J, 2023) |
| "Current treatments of high-grade squamous intraepithelial lesion (HSIL) of the cervix are based on invasive surgical interventions, compromising cervical competence and functionality." | 3.11 | Multicentre, prospective, randomised controlled trial to evaluate hexaminolevulinate photodynamic therapy (Cevira) as a novel treatment in patients with high-grade squamous intraepithelial lesion: APRICITY phase 3 study protocol. ( Chen, F; Dannecker, C; Han, L; Hillemanns, P; Lang, J; Mokráš, C; Novák, Z; Sui, L; You, Z; Zhang, Y, 2022) |
| "To evaluate the effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser pretreatment (Laser+ALA-PDT) on patients with cervical high-grade squamous intraepithelial lesions (HSILs)." | 1.91 | Effect of topical 5-aminolevulinic acid photodynamic therapy versus therapy combined with CO2 laser pretreatment for patients with cervical high-grade squamous intraepithelial lesions. ( Feng, C; Gu, L; Hong, Z; Qiu, L; Wang, L; Wei, Y; Wu, D, 2023) |
| "Cervical high-grade squamous intraepithelial lesions (HSIL), as pre-cancerous lesions, have a 5% chance of progressing to invasive cancer." | 1.72 | The effect of high-risk HPV E6/E7 mRNA on the efficacy of topical photodynamic therapy with 5-aminolevulinic acid for cervical high-grade squamous intraepithelial lesions. ( Cao, L; Qin, L; Shen, Y; Su, Y; Tang, Y; Wang, B; Wang, L; Zhang, L; Zhang, M; Zhang, T; Zhang, Y; Zhou, Y, 2022) |
| "High-risk HPV infection is the main cause of cervical cancer and pre-cancerous lesions." | 1.62 | The effect of local photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical low-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study. ( Cheng, M; Di, W; Gu, L; Hong, Z; Qiu, L, 2021) |
| "Progression to high-grade squamous intraepithelial lesion warrants intervention." | 1.62 | The effect of local photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical low-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study. ( Cheng, M; Di, W; Gu, L; Hong, Z; Qiu, L, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 10 (90.91) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, X | 1 |
| You, L | 1 |
| Zhang, W | 1 |
| Ma, Y | 1 |
| Tang, Y | 3 |
| Xu, W | 1 |
| Su, Y | 2 |
| Xu, Y | 2 |
| Zhang, Y | 4 |
| Shen, Y | 2 |
| Qin, L | 2 |
| Zhang, L | 2 |
| Cao, L | 2 |
| Zhou, Y | 2 |
| Zhang, T | 2 |
| Zhang, M | 2 |
| Chen, F | 1 |
| Novák, Z | 1 |
| Dannecker, C | 1 |
| Mokráš, C | 1 |
| Sui, L | 1 |
| You, Z | 1 |
| Han, L | 1 |
| Lang, J | 1 |
| Hillemanns, P | 1 |
| Wang, B | 1 |
| Wang, L | 3 |
| Liu, X | 1 |
| Zhang, J | 2 |
| Jia, L | 1 |
| Hu, Y | 1 |
| Li, Y | 2 |
| Teng, Y | 1 |
| Chen, J | 1 |
| Ma, L | 1 |
| Qu, Z | 1 |
| Wang, Z | 1 |
| Qiu, S | 1 |
| Cui, G | 1 |
| Li, C | 1 |
| Jiang, S | 1 |
| Nan, X | 1 |
| Pan, X | 1 |
| Tang, L | 1 |
| Gong, H | 1 |
| Feng, C | 1 |
| Gu, L | 2 |
| Hong, Z | 2 |
| Wei, Y | 1 |
| Wu, D | 1 |
| Qiu, L | 2 |
| Cheng, M | 1 |
| Di, W | 1 |
| Meng, X | 1 |
| Shi, X | 1 |
| Luan, H | 1 |
| Liu, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of 5-aminolaevulinic Acid Photodynamic Therapy Versus C02 Laser in the Treatment of Persistent Cervical Low-grade Squamous Intraepithelial Lesions With High-risk HPV Infection:A Non-randomized Controlled Trail Study[NCT06052033] | 40 participants (Anticipated) | Interventional | 2023-09-11 | Recruiting | |||
| A Double Blind, Prospective, Randomized, Placebo Controlled, Multi-center Phase 3 Study to Evaluate Efficacy and Safety of Cevira® in Patients With Cervical Histologic High-grade Squamous Intraepithelial Lesions (HSIL)[NCT04484415] | Phase 3 | 402 participants (Actual) | Interventional | 2020-11-10 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for aminolevulinic acid and Squamous Intraepithelial Lesions
| Article | Year |
|---|---|
Multicentre, prospective, randomised controlled trial to evaluate hexaminolevulinate photodynamic therapy (Cevira) as a novel treatment in patients with high-grade squamous intraepithelial lesion: APRICITY phase 3 study protocol.
Topics: Aminolevulinic Acid; Carcinoma in Situ; Clinical Trials, Phase III as Topic; Female; Humans; Multice | 2022 |
The effect of aminolevulinic acid hydrochloride topical powder photodynamic therapy versus nocardia rubra cell wall skeleton and observers group in the treatment of cervical low-grade squamous intraepithelial lesions with human papillomavirus infection: A
Topics: Aminolevulinic Acid; Cell Wall Skeleton; Female; Human Papillomavirus Viruses; Humans; Papillomaviru | 2023 |
9 other studies available for aminolevulinic acid and Squamous Intraepithelial Lesions
| Article | Year |
|---|---|
Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy on cervical low-grade squamous intraepithelial lesions with high-risk HPV infection.
Topics: Aminolevulinic Acid; Cervix Uteri; Ectropion; Female; Humans; Papillomavirus Infections; Photochemot | 2022 |
Therapeutic effects of topical photodynamic therapy with 5-aminolevulinic acid on cervical high-grade squamous intraepithelial lesions.
Topics: Adolescent; Adult; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Humans; Middle Aged; Papil | 2022 |
The effect of high-risk HPV E6/E7 mRNA on the efficacy of topical photodynamic therapy with 5-aminolevulinic acid for cervical high-grade squamous intraepithelial lesions.
Topics: Aminolevulinic Acid; Female; Human papillomavirus 16; Human papillomavirus 18; Humans; Neoplasm Recu | 2022 |
Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy in postmenopausal women with persistent HPV infection with or without cervical and vaginal low-grade squamous intraepithelial lesions (CIN1/VaIN1).
Topics: Aminolevulinic Acid; Female; Humans; Papillomaviridae; Papillomavirus Infections; Photochemotherapy; | 2022 |
Topical 5-aminolevulinic acid photodynamic therapy for cervical high-grade squamous intraepithelial lesions.
Topics: Aminolevulinic Acid; Female; Humans; Papillomaviridae; Papillomavirus Infections; Photochemotherapy; | 2022 |
Efficacy of photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical high-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study.
Topics: Aminolevulinic Acid; Female; Humans; Papillomavirus Infections; Photochemotherapy; Retrospective Stu | 2022 |
Effect of topical 5-aminolevulinic acid photodynamic therapy versus therapy combined with CO2 laser pretreatment for patients with cervical high-grade squamous intraepithelial lesions.
Topics: Aminolevulinic Acid; Human papillomavirus 16; Human papillomavirus 18; Humans; Lasers, Gas; Papillom | 2023 |
The effect of local photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical low-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study.
Topics: Adult; Aged; Aminolevulinic Acid; Female; Human papillomavirus 16; Human papillomavirus 18; Humans; | 2021 |
LEEP/Cone combined with photodynamic therapy for successful treatment of high-grade squamous intraepithelial lesion.
Topics: Adult; Aminolevulinic Acid; Combined Modality Therapy; Conization; Electrosurgery; Female; Humans; P | 2019 |