Page last updated: 2024-09-27

Angioleiomyoma

A benign tumor consisting of vascular and smooth muscle elements.

Synonyms(3)

Synonym
Angiomyoma
Leiomyoma, Vascular
Angioleiomyoma

Research Excerpts

Overview

ExcerptReference
"Angioleiomyomas are smooth muscle tumors that occur most often in the extremities and are usually less than 2 cm in diameter."( Fukahori, S; Hayabuchi, N; Nagata, S; Nishimura, H; Uchida, M; Zenmyou, M, 2006)
"Epithelioid angioleiomyoma is rare in the skin and subcutis."( Liao, SL; Liu, JY; Zheng, J, 2007)
"Angioleiomyoma is a solitary form of leiomyoma that usually occurs as a painful subcutaneous lesion, with a predilection for the lower extremities of middle-aged women."( Huang, KC; Lee, KF, 2008)
"Angioleiomyoma is a rare, benign smooth muscle tumour arising from the tunica media of small veins and arteries and can occur anywhere in the body."( Butt, SH; Gupte, C; Saifuddin, A; Tirabosco, R, 2008)
"Angioleiomyoma is a rare lesion of the internal auditory canal that has many similar clinical and radiographic features of a vestibular schwannoma."( Arts, HA; Gebarski, S; McKeever, P; Pepper, JP; Spector, M; Thompson, BG, 2010)
"Angioleiomyomas are benign solitary soft-tissue tumors that originate from the vascular smooth muscle of vessels and rarely occur in the hand."( Fukasawa, K; Kobayashi, K; Otsuka, H, 2013)
"Angioleiomyoma is a benign smooth muscle tumor."( Akatsu, Y; Fukawa, T; Sasho, T, 2014)
"Angioleiomyoma is a benign tumour composed of smooth muscle and vascular tissue."( Kulkarni, MS; Naik, M; Rao, SK; Vijayan, S, 2017)
"Angioleiomyomas are benign tumors originating in the vascular smooth muscles."( Abdulkareem, IH; Hamed, RA; Younis, AA, 2019)
"Orbital angioleiomyoma is a rare benign tumour and the lesion can cause visual morbidity, particularly when intraconal."( Cook, A; Irion, L; Laybourne, J; Wong, SW, 2021)
"Angioleiomyoma is a benign soft tissue tumor which usually occurs in superficial or deep soft tissues."( Magro, G; Salvatorelli, L; Vecchio, GM, 2020)
"Angioleiomyomas are benign neoplasms, which usually present as solitary, slow-growing nodules on the skin of lower extremities, but acral location on the hands or feet is unusual."( Fernández-Figueras, MT; Pérez-Muñoz, N; Pita da Veiga, G; Suárez-Peñaranda, JM, 2021)
"Angioleiomyoma is a rare benign soft tissue tumour arising from smooth muscle, representing <1% of upper limb soft tissue tumours."( Amrutiya, PA; Brown, OS; Mallina, R; Papanikos, E, 2023)

Treatment

ExcerptReference
"We review the literature on angioleiomyoma and report careful resection of the tumour with digital artery transection and repair as a treatment option for angioleiomyoma of the digital artery."( Amrutiya, PA; Brown, OS; Mallina, R; Papanikos, E, 2023)

Research

Studies (47)

TimeframeStudies, This Condition (%)All Conditions %
pre-19908 (17.02)23.3326
1990's7 (14.89)12.5806
2000's17 (36.17)18.1394
2010's9 (19.15)28.8240
2020's6 (12.77)9.53
DrugIndicatedRelationship StrengthStudiesTrials
bupivacaine0low10
lidocaine0low10
khellin0low10
prednisone0low10
valine0low10
reticulin0low10
medroxyprogesterone0low10
technetium0low30
gadolinium0low10
triamcinolone0low10
propiconazole0low40
leuprolide0low10
toremifene0low10
phenylephrine hydrochloride0low10
gadolinium dtpa0low20
acyclovir0low10
valacyclovir0low10

Protein Targets (244)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain2002
Thymidine kinase 0101
thioredoxin reductase5005
phosphopantetheinyl transferase2002
GLS protein2002
TDP1 protein8008
Smad32002
thyroid stimulating hormone receptor1001
EWS/FLI fusion protein2002
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 26006
activating transcription factor 61001
Histone H2A.x1001
Bloom syndrome protein isoform 13003
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lamin isoform A-delta106006
Solute carrier family 22 member 1 0001
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Solute carrier family 22 member 60102
Bile salt export pump0202
Bile salt export pump0303
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0303
Cytochrome P450 2J20202
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60102
Thymidine kinase 0101
Solute carrier family 22 member 80103
Canalicular multispecific organic anion transporter 10202
Thymidine kinase0101
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20112
Potassium channel subfamily K member 90101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
glp-1 receptor, partial4004
USP1 protein, partial2002
GALC protein3003
GLI family zinc finger 36006
aldehyde dehydrogenase 1 family, member A14004
nuclear receptor subfamily 1, group I, member 34004
cytochrome P450 family 3 subfamily A polypeptide 42002
G2002
cytochrome P450 2D61001
aryl hydrocarbon receptor2002
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C19 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
importin subunit beta-1 isoform 11001
mitogen-activated protein kinase 12002
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
peripheral myelin protein 223003
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
histone acetyltransferase KAT2A isoform 13003
Gamma-aminobutyric acid receptor subunit pi3003
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 2002
Cellular tumor antigen p534004
Cytochrome P450 1A10202
Cytochrome P450 1A20202
Cytochrome P450 3A40202
Cytochrome P450 2D60101
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Cytochrome P450 2C190202
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Cytochrome P450 1B10101
GABA theta subunit3003
Inositol hexakisphosphate kinase 12002
Gamma-aminobutyric acid receptor subunit epsilon3003
cytochrome P450 2C9, partial2002
Gonadotropin-releasing hormone receptor0101
Gonadotropin-releasing hormone receptor0202
Chain A, Beta-lactamase4004
RAR-related orphan receptor gamma5005
Microtubule-associated protein tau2002
AR protein6006
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
IDH12002
chromobox protein homolog 15005
flap endonuclease 11001
geminin5005
muscarinic acetylcholine receptor M11001
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0101
Potassium voltage-gated channel subfamily H member 20101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Multidrug and toxin extrusion protein 10101
Sodium channel protein type 3 subunit alpha0101
SMAD family member 23003
SMAD family member 33003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
PINK11001
progesterone receptor4004
glucocorticoid receptor [Homo sapiens]5005
estrogen-related nuclear receptor alpha5005
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha6006
Parkin1001
peroxisome proliferator activated receptor gamma3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
thyroid hormone receptor beta isoform 23003
nuclear factor erythroid 2-related factor 2 isoform 15005
Glucocorticoid receptor0617
Glycine receptor subunit alpha-10606
Androgen receptor0202
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Spike glycoprotein3014
Chain A, 2-oxoglutarate Oxygenase2002
thyroid stimulating hormone receptor1001
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
pregnane X receptor2002
thioredoxin glutathione reductase3003
estrogen receptor 2 (ER beta)2002
retinoic acid nuclear receptor alpha variant 12002
v-jun sarcoma virus 17 oncogene homolog (avian)1001
vitamin D3 receptor isoform VDRA2002
nuclear factor erythroid 2-related factor 2 isoform 22002
nuclear receptor ROR-gamma isoform 12002
Nuclear receptor ROR-gamma1001
nonstructural protein 11001
retinoid X nuclear receptor alpha2002
farnesoid X nuclear receptor1001
peroxisome proliferator-activated receptor delta1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid hormone receptor beta isoform a1001
heat shock protein HSP 90-alpha isoform 20001
DNA polymerase iota isoform a (long)1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent calcium channel gamma-2 subunit1001
Glutamate receptor 21001
Histamine H2 receptor1001
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 431001
ATPase family AAA domain-containing protein 52002
Ataxin-22002
heat shock protein 90, putative0001
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Albumin0101
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
PPM1D protein1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
5-hydroxytryptamine receptor 60101
Envelope glycoprotein0022
Angiotensin-converting enzyme 2 0011
ATAD5 protein, partial1001
NFKB1 protein, partial1001
peripheral myelin protein 22 isoform 11001
heat shock protein beta-11001
procathepsin L isoform 1 preproprotein0101
muscleblind-like protein 1 isoform 11001
Solute carrier family 15 member 10203
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
Valacyclovir hydrolase0001
Chain A, Arginase 10101
Large neutral amino acids transporter small subunit 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]