Page last updated: 2024-09-27

Donohue Syndrome

Rare autosomal recessive syndrome, characterized by a milder set of clinical features with prolonged survival, compared to Donohue syndrome. Mutations in the same INSULIN RECEPTOR, mostly in the non-binding domain, result in Rabson-Mendenhall syndrome (allelic heterogeneity). Clinical features include insulin-resistant DIABETES MELLITUS, often with ACANTHOSIS NIGRICANS; DIABETIC KETOACIDOSIS; HYPERTRICHOSIS; and dysmorphisms.

Synonyms(5)

Synonym
Donohue Syndrome
Mendenhall Syndrome
Leprechaunism
Rabson-Mendenhall Syndrome
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities

Research Excerpts

Research

Studies (10)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's7 (70.00)28.8240
2020's3 (30.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
pioglitazone0low20
propranolol0low20
glutamine0low10
histidine0low10
adamantane0low10
glucose, (beta-d)-isomer0low10
vildagliptin0low10
empagliflozin0low10
c-peptide0low10
leptin0medium32

Protein Targets (195)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Sodium/glucose cotransporter 10011
Sodium/glucose cotransporter 20112
Glycogen phosphorylase, muscle form0101
Asialoglycoprotein receptor 10112
Chain A, Glutamine Binding Protein0011
thioredoxin reductase2002
15-lipoxygenase, partial1001
GLS protein1001
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 23003
Bloom syndrome protein isoform 11001
peripheral myelin protein 22 isoform 11001
flap endonuclease 12002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Carbonic anhydrase 10003
Carbonic anhydrase 20104
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Carbonic anhydrase-like protein, putative0002
Amino acid transporter0101
ATP-dependent phosphofructokinase1001
Chain A, HISTIDINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
ATAD5 protein, partial1001
cytochrome P450 3A4 isoform 11001
histone acetyltransferase KAT2A isoform 11001
Gamma-aminobutyric acid receptor subunit pi1113
Carbonic anhydrase 120001
Plasma kallikrein0001
Carbonic anhydrase 30001
Histidine-binding periplasmic protein0011
Gamma-aminobutyric acid receptor subunit beta-11113
Gamma-aminobutyric acid receptor subunit delta1113
Gamma-aminobutyric acid receptor subunit gamma-21113
Gamma-aminobutyric acid receptor subunit alpha-51113
Gamma-aminobutyric acid receptor subunit alpha-31113
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Gamma-aminobutyric acid receptor subunit gamma-11113
Gamma-aminobutyric acid receptor subunit alpha-21113
Adenosine receptor A10001
5-hydroxytryptamine receptor 1D0001
Gamma-aminobutyric acid receptor subunit alpha-41113
Gamma-aminobutyric acid receptor subunit gamma-31113
Gamma-aminobutyric acid receptor subunit alpha-61113
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Carbonic anhydrase0001
Gamma-aminobutyric acid receptor subunit alpha-11113
Gamma-aminobutyric acid receptor subunit beta-31113
Gamma-aminobutyric acid receptor subunit beta-21113
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0001
GABA theta subunit1113
Carbonic anhydrase 40001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Gamma-aminobutyric acid receptor subunit epsilon1113
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
TDP1 protein2002
aldehyde dehydrogenase 1 family, member A11001
EWS/FLI fusion protein1001
CDGSH iron-sulfur domain-containing protein 10101
tyrosine-protein kinase Yes1001
Free fatty acid receptor 10011
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Bile salt export pump0202
Peroxisome proliferator-activated receptor gamma0101
Bile salt export pump0303
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor M30011
Muscarinic acetylcholine receptor M40011
Steryl-sulfatase0101
Muscarinic acetylcholine receptor M50011
Muscarinic acetylcholine receptor M20011
Tyrosine-protein phosphatase non-receptor type 10101
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0101
Peroxisome proliferator-activated receptor alpha0101
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Amine oxidase [flavin-containing] B0202
Peroxisome proliferator-activated receptor gamma0225
Peroxisome proliferator-activated receptor gamma0112
Carnitine O-palmitoyltransferase 1, liver isoform0101
Peroxisome proliferator-activated receptor alpha0112
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
CDGSH iron-sulfur domain-containing protein 20101
CDGSH iron-sulfur domain-containing protein 10202
Beta-1 adrenergic receptor 0113
D(1A) dopamine receptor1001
Solute carrier family 22 member 1 0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
5-hydroxytryptamine receptor 40202
Albumin0011
Cytochrome P450 1A20101
Beta-2 adrenergic receptor0213
Muscarinic acetylcholine receptor M20112
ATP-dependent translocase ABCB10202
Beta-1 adrenergic receptor0213
Cytochrome P450 3A40101
5-hydroxytryptamine receptor 1A0101
Alpha-2A adrenergic receptor0124
Adenosine receptor A30112
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
Cytochrome P450 2D60101
Muscarinic acetylcholine receptor M10112
Cytochrome P450 2C9 0101
Beta-3 adrenergic receptor0213
D(2) dopamine receptor0112
Alpha-1B adrenergic receptor0112
Alpha-2B adrenergic receptor0012
Beta-1 adrenergic receptor0214
Alpha-2C adrenergic receptor0124
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0214
Alpha-2B adrenergic receptor0011
Muscarinic acetylcholine receptor M30112
D(1A) dopamine receptor0112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Alpha-1D adrenergic receptor0112
Alpha-1D adrenergic receptor0012
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 2A0213
5-hydroxytryptamine receptor 2C0213
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Sodium-dependent serotonin transporter0202
Cholecystokinin receptor type A0112
Cytochrome P450 2C190101
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Mu-type opioid receptor0112
Vasopressin V1a receptor0112
Delta-type opioid receptor0112
Kappa-type opioid receptor0112
5-hydroxytryptamine receptor 2B0213
Alpha-1A adrenergic receptor0112
5-hydroxytryptamine receptor 60213
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
Beta-2 adrenergic receptor0101
Potassium voltage-gated channel subfamily H member 20101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
Canalicular multispecific organic anion transporter 10202
Ataxin-21001
Sigma non-opioid intracellular receptor 10202
Nuclear receptor subfamily 2 group E member 10022
Dipeptidyl peptidase 90101
Dipeptidyl peptidase IV0202
Kynurenine 3-monooxygenase0101
Heat shock protein HSP 90-beta0101
Dipeptidyl peptidase 40101
Dipeptidyl peptidase 40213
Dipeptidyl peptidase 40101
Prolyl endopeptidase0101
Prolyl endopeptidase FAP0101
Prolyl endopeptidase FAP0101
Dipeptidyl peptidase 80202
Dipeptidyl peptidase 90202
Dipeptidyl peptidase 20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]