Page last updated: 2024-09-27

Arcus Corneae

A corneal disease in which there is a deposition of phospholipid and cholesterol in the corneal stroma and anterior sclera.

Synonyms(3)

Synonym
Arcus Senilis
Arcus Corneae
Corneal Arcus

Research Excerpts

Overview

ExcerptReference
"Corneal arcus is a lipid-rich deposit at the corneoscleral limbus that shares some similarities with the lipid deposition of atherosclerosis."( D'Agostino, R; Fernandez, AB; Keyes, MJ; O'Donnell, CJ; Pencina, M; Thompson, PD, 2009)
"Corneal arcus is associated with CVD, independent of risk factors in ethnic Indian adults, even in those at low risk for vascular disease."( Ang, M; Cajucom-Uy, H; Lavanya, R; Park, J; Tai, ES; Wong, TY; Wong, W; Wu, R; Zheng, Y, 2011)

Research

Studies (77)

TimeframeStudies, This Condition (%)All Conditions %
pre-199049 (63.64)23.3326
1990's9 (11.69)12.5806
2000's11 (14.29)18.1394
2010's7 (9.09)28.8240
2020's1 (1.30)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
uric acid0low10
1-anilino-8-naphthalenesulfonate0low10
bendroflumethiazide0low10
erythrosine0low10
2-propanol0low50
pyridinolcarbamate0low10
thyroxine0low10
pyrroles0low10
simvastatin0low10
atorvastatin0low20
fibrinogen0low20
cysteine0low10
glycolipids0low10
exudates0low10
eye0low30

Protein Targets (243)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase1001
thioredoxin reductase3003
USP1 protein, partial2002
TDP1 protein4004
vitamin D3 receptor isoform VDRA4004
importin subunit beta-1 isoform 11001
flap endonuclease 11001
serine/threonine-protein kinase PLK13003
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin4004
DNA polymerase kappa isoform 14004
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0101
Transthyretin0113
Fatty acid-binding protein, intestinal0112
Fatty acid-binding protein, adipocyte0112
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20112
Choline O-acetyltransferase0101
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G1001
Fatty acid-binding protein 50011
Fatty acid-binding protein 50011
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140101
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma6006
GLI family zinc finger 34004
AR protein4004
aldehyde dehydrogenase 1 family, member A13003
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha5005
estrogen nuclear receptor alpha6006
peroxisome proliferator-activated receptor delta5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
activating transcription factor 62002
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x3003
thyroid hormone receptor beta isoform a4004
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 14004
lamin isoform A-delta103003
Voltage-dependent calcium channel gamma-2 subunit3003
Glutamate receptor 23003
Chain A, Cruzipain1001
SMAD family member 23003
SMAD family member 33003
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 33003
glucocorticoid receptor [Homo sapiens]2002
estrogen-related nuclear receptor alpha4004
pregnane X nuclear receptor2002
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
caspase-31001
Caspase-71001
caspase-31001
thyroid hormone receptor beta isoform 24004
Solute carrier organic anion transporter family member 2B1 0001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0404
Cellular tumor antigen p534004
ATP-dependent translocase ABCB10202
Insulin receptor 0202
Dipeptidyl peptidase 40101
Prostaglandin G/H synthase 20303
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
Histone deacetylase 10101
Histone deacetylase 20101
Solute carrier organic anion transporter family member 1B30001
Histone deacetylase 60101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Solute carrier organic anion transporter family member 1B10204
Chain A, 2-oxoglutarate Oxygenase2002
acetylcholinesterase2002
glp-1 receptor, partial1001
chromobox protein homolog 11001
potassium voltage-gated channel subfamily H member 2 isoform d1001
cytochrome P450 3A4 isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Bile salt export pump0303
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
TAR DNA-binding protein 432002
GABA theta subunit1001
Gamma-aminobutyric acid receptor subunit epsilon1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Beta-lactamase2002
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Genome polyprotein 0112
Luciferase1001
chaperonin-containing TCP-1 beta subunit homolog2002
phosphopantetheinyl transferase1001
ATAD5 protein, partial1001
Fumarate hydratase1001
GLS protein1001
thioredoxin glutathione reductase1001
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 43003
farnesoid X nuclear receptor2002
G3003
cytochrome P450 2D62002
polyprotein1001
bromodomain adjacent to zinc finger domain 2B2002
euchromatic histone-lysine N-methyltransferase 22002
aryl hydrocarbon receptor2002
thyroid stimulating hormone receptor1001
thyrotropin-releasing hormone receptor1001
Bloom syndrome protein isoform 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eyes absent homolog 2 isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
histone acetyltransferase KAT2A isoform 12002
relaxin receptor 1 isoform 11001
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Flavin reductase (NADPH)0011
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
ATP-dependent phosphofructokinase1001
large T antigen0101
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
survival motor neuron protein isoform d1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Albumin0101
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60102
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80202
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Chain A, Ferritin light chain1001
Smad31001
PINK11001
regulator of G-protein signaling 41001
EWS/FLI fusion protein2002
Parkin1001
photoreceptor-specific nuclear receptor0101
IDH11001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 21001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Nuclear receptor subfamily 4 group A member 20011
Spike glycoprotein1001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Sigma non-opioid intracellular receptor 10101
Canalicular multispecific organic anion transporter 10101
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
Solute carrier organic anion transporter family member 1A40001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]