Page last updated: 2024-11-12
ustiloxin b
Description
ustiloxin B: an antimitotic cyclic peptide; from false smut balls on rice panicles caused by Ustilaginoidea virens; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ustiloxin B : A heterodetic cyclic peptide with formula C26H39N5O12S produced by Ustilaginoidea virens fungi. It is an inhibitor of microtubule assembly. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 9917502 |
| MeSH ID | M0235570 |
Synonyms (6)
| Synonym |
|---|
| glycine, 2-((4-amino-4-carboxy-2-hydroxybutyl)sulfinyl)-threo-beta,5-dihydroxy-n-methyl-l-tyrosyl-l-alanyl-3-hydroxy-l-isoleucyl-, cyclic (15-3)-ether, (2s-(1(s*),2r*,4r*))- |
| ustiloxin b |
| glycine, (betar)-2-((r)-((2s,4s)-4-amino-4-carboxy-2-hydroxybutyl)sulfinyl)-beta,5-dihydroxy-n-methyl-l-tyrosyl-l-alanyl-3-hydroxy-l-isoleucyl-, cyclic (15-3)-ether |
| 151841-41-7 |
| (2s,4s)-2-amino-5-[[(3r,4s,7s,10s,11r)-4-(carboxymethylcarbamoyl)-3-ethyl-11,15-dihydroxy-3,7-dimethyl-10-(methylamino)-6,9-dioxo-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(15),12(16),13-trien-13-yl]sulfinyl]-4-hydroxypentanoic acid |
| DTXSID401017606 |
Research Excerpts
Overview
Ustiloxin B is a secondary metabolite known to be produced by Ustilaginoidea virens. It is an antimitotic cyclopeptide mycotoxin isolated from rice false smut balls that formed in the pathogen-infected rice spikelets.
| Excerpt | Reference | Relevance |
|---|
| "Ustiloxin B is a ribosomally synthesized and post-translationally modified peptide (RiPP) first reported in Ascomycetes. " | ( Tandem repeats in precursor protein stabilize transcript levels and production levels of the fungal ribosomally synthesized and post-translationally modified peptide ustiloxin B.
Kuriiwa, K; Umemura, M; Viet Dao, L, 2022) | 2.36 |
| "Ustiloxin B is a secondary metabolite known to be produced by Ustilaginoidea virens. " | ( Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic peptide ustiloxin B in Aspergillus flavus.
Ishii, T; Kawano, J; Kikuchi, M; Koike, H; Machida, M; Miyamura, Y; Nagano, N; Shin-ya, K; Tamano, K; Umemura, M; Yu, J, 2014) | 2.06 |
| "Ustiloxin B is an antimitotic cyclopeptide mycotoxin isolated from the rice false smut balls that formed in the pathogen-infected rice spikelets." | ( Development of a Monoclonal Antibody-Based icELISA for the Detection of Ustiloxin B in Rice False Smut Balls and Rice Grains.
Fu, X; He, L; Lai, D; Li, QX; Lin, F; Liu, Y; Wang, A; Wang, B; Wang, X; Zhou, L, 2015) | 1.37 |
Roles (3)
| Role | Description |
|---|
| microtubule-destabilising agent | Any substance that interacts with tubulin to inhibit polymerisation of microtubules. |
| mycotoxin | Poisonous substance produced by fungi. |
| Aspergillus metabolite | Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (7)
| Class | Description |
|---|
| heterodetic cyclic peptide | A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond. |
| sulfoxide | An organosulfur compound having the structure R2S=O or R2C=S=O (R =/= H). |
| macrocycle | A cyclic compound containing nine or more atoms as part of the cyclic system. |
| secondary carboxamide | A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1). |
| phenols | Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring. |
| aromatic ether | Any ether in which the oxygen is attached to at least one aryl substituent. |
| secondary alcohol | A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (18)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 12 (66.67) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.94
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.94 (24.57) | | Research Supply Index | 2.94 (2.92) | | Research Growth Index | 5.89 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 18 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |