aspirochlorine: inhibitor of fungal protein synthesis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 44559211 |
| CHEMBL ID | 470243 |
| CHEBI ID | 68861 |
| MeSH ID | M0305709 |
| Synonym |
|---|
| CHEMBL470243 |
| chebi:68861 , |
| aspirochlorine |
| Q27137217 |
Aspirochlorine is an antifungal cyclopeptide produced by Aspergillus oryzae. The mold has been used in the oriental cuisine for over two millennia.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Aspirochlorine is an unusual antifungal cyclopeptide produced by Aspergillus oryzae, an important mold used for food fermentation. " | ( Enzymatic Amide Tailoring Promotes Retro-Aldol Amino Acid Conversion To Form the Antifungal Agent Aspirochlorine. Chankhamjon, P; Hertweck, C; Maeda, N; Scherlach, K; Tsunematsu, Y; Watanabe, K; Yokoyama, M, 2018) | 2.14 |
| "Aspirochlorine (1) is an epidithiodiketopiperazine (ETP) toxin produced from koji mold (Aspergillus oryzae), which has been used in the oriental cuisine for over two millennia. " | ( Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion. Boettger-Schmidt, D; Chankhamjon, P; Dahse, HM; Hertweck, C; Hoffmeister, D; Kalb, D; Lackner, G; Scherlach, K; Urbansky, B, 2014) | 2.11 |
| Role | Description |
|---|---|
| Aspergillus metabolite | Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| organic heterotetracyclic compound | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID403740 | Antifungal activity against azole-resistant Candida albicans 99-788 | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8 | Aspirochlorine class compounds from Aspergillus flavus inhibit azole-resistant Candida albicans. |
| AID403741 | Cytotoxicity against human CEM cells after 96 hrs | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8 | Aspirochlorine class compounds from Aspergillus flavus inhibit azole-resistant Candida albicans. |
| AID403742 | Therapeutic index, IC50 for human CEM cells to IC 50 for azole-resistant Candida albicans 99-788 | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8 | Aspirochlorine class compounds from Aspergillus flavus inhibit azole-resistant Candida albicans. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (22.37) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||