Asherman Syndrome

Absence of a normal opening in the lumen of the female genital tract, from the FALLOPIAN TUBES to the VAGINA. This anomaly may be congenital or acquired due to injuries, diseases, or TISSUE ADHESIONS.

Synonyms(5)

Synonym
Intrauterine Synechiae
Asherman's Syndrome
Uterine Synechiae
Asherman Syndrome
Gynatresia

Research Excerpts

Overview

Excerpt	Reference
"Asherman's syndrome is being diagnosed with increasing frequency."	( March, CM, 2011)

Research

Studies (19)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	3 (15.79)	18.1394
2010's	9 (47.37)	28.8240
2020's	7 (36.84)	9.53

Drug	Relationship Strength	Studies
metformin	low	1
zaleplon	low	1
medroxyprogesterone acetate	low	1
megestrol acetate	low	1
levonorgestrel	low	1
ozone	low	1
tamoxifen	low	1
transforming growth factor beta	low	1
sildenafil citrate	low	1

Protein Targets (279)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	4	0	0	4
SMAD family member 2	4	0	0	4
ATAD5 protein, partial	2	0	0	2
USP1 protein, partial	2	0	0	2
SMAD family member 3	4	0	0	4
TDP1 protein	4	0	0	4
GLI family zinc finger 3	6	0	0	6
AR protein	5	0	0	5
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
progesterone receptor	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
glucocorticoid receptor [Homo sapiens]	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	5	0	0	5
retinoid X nuclear receptor alpha	4	0	0	4
estrogen-related nuclear receptor alpha	5	0	0	5
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	5	0	0	5
estrogen nuclear receptor alpha	7	0	0	7
G	5	0	0	5
peroxisome proliferator-activated receptor delta	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
thyroid stimulating hormone receptor	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Histone H2A.x	2	0	0	2
chromobox protein homolog 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
thyroid hormone receptor beta isoform 2	4	0	0	4
DNA polymerase beta	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	2	0	0	2
geminin	5	0	0	5
peripheral myelin protein 22	1	0	0	1
lamin isoform A-delta10	4	0	0	4
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	7
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	7	0	7
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Cellular tumor antigen p53	4	0	0	4
Progesterone receptor	0	3	2	5
Glutamate receptor 2	3	0	0	3
Inositol hexakisphosphate kinase 1	5	0	0	5
Canalicular multispecific organic anion transporter 1	0	7	0	7
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
cytochrome P450 2C9, partial	5	0	0	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Cruzipain	2	0	0	2
interleukin 8	1	0	0	1
pregnane X receptor	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	1	0	0	1
PINK1	1	0	0	1
nonstructural protein 1	1	0	0	1
Parkin	1	0	0	1
peroxisome proliferator activated receptor gamma	3	0	0	3
IDH1	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
cytochrome P450 3A4 isoform 1	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Estrogen receptor	0	3	2	6
Glucocorticoid receptor	0	4	1	5
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Mineralocorticoid receptor	0	1	0	1
Androgen receptor	0	2	2	4
Androgen receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Androgen receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Glycine receptor subunit alpha-3	0	4	0	4
Histamine H2 receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
5-hydroxytryptamine receptor 1B	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Alpha-synuclein	2	0	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Spike glycoprotein	1	0	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Guanine nucleotide-binding protein G	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Aldo-keto reductase family 1 member C1	0	1	0	1
GABA theta subunit	2	0	0	2
Estrogen receptor beta	0	3	2	5
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
bioA	0	0	0	1
survival motor neuron protein isoform d	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Cytochrome P450 2C9	0	1	0	1
Chain A, Ferritin light chain	3	0	0	3
EWS/FLI fusion protein	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Solute carrier family 22 member 1	0	0	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
Carbonic anhydrase 12	0	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Carbonic anhydrase 1	0	0	0	1
Carbonic anhydrase 2	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Chain A, CES1 protein	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
acetylcholinesterase	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
Fumarate hydratase	1	0	0	1
PPM1D protein	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
DNA polymerase III, partial	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
polyprotein	1	0	0	1
67.9K protein	1	0	0	1
glucocerebrosidase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
arylsulfatase A	1	0	0	1
caspase-3	1	0	0	1
activating transcription factor 6	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
interferon gamma precursor	0	0	0	1
D(1A) dopamine receptor	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
caspase-3	1	0	0	1
heat shock protein beta-1	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
streptokinase A precursor	0	0	1	1
lethal factor (plasmid)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transmembrane protease serine 2	0	0	1	1
5-hydroxytryptamine receptor 4	0	2	0	2
Serine/threonine-protein kinase D3	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Integrin beta-3	1	0	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	2	1	3
Integrin alpha-IIb	1	0	0	1
Beta-1 adrenergic receptor	0	2	0	2
Cytochrome P450 3A4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	0	1	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Adenosine receptor A2a	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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