Page last updated: 2024-09-27

Anetoderma

Benign DERMATOSIS caused by a loss of dermal ELASTIC TISSUE resulting in localized sac-like areas of flaccid skin. It can be either primary (idiopathic) or secondary to other skin conditions, PENICILLAMINE use, or premature birth.

Synonyms(3)

Synonym
Anetoderma, Secondary
Anetoderma, Primary
Anetoderma

Research Excerpts

Overview

ExcerptReference
"Anetoderma is an uncommon disease characterized by multiple circumscribed atrophic, herniated skin lesions on trunk, thighs and upper arms caused by loss of elastic fibers."( Hetzer, S; Homey, B; Reifenberger, J; Strunk, T, 2011)
"Anetoderma is a skin disorder characterized by a focal loss of dermal elastic tissue whereby patients present with soft, depressible lesions."( Ross, NA; Saedi, N; Wang, K, 2016)

Treatment

ExcerptReference
"Our patient with biopsy proven anetoderma received 3 treatments with a combination of 595-nm PDL and 1550-nm NAFL spaced 3 weeks apart."( Ross, NA; Saedi, N; Wang, K, 2016)

Research

Studies (13)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (15.38)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's9 (69.23)28.8240
2020's2 (15.38)9.53
DrugIndicatedRelationship StrengthStudiesTrials
dalteparin0low10
dapsone0low10
fenofibrate0low10
prednisolone0low10
potassium hydroxide0low10
simvastatin0low10
itraconazole0low10
elastin0low20
isotretinoin0low10
vitamin k 10low10
deamino arginine vasopressin0low10
gadolinium dtpa0low10
warfarin0low10

Protein Targets (287)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Beta-lactamase3003
Chain A, Ferritin light chain4004
Luciferase3003
interleukin 82002
endonuclease IV2002
PAX80001
thioredoxin reductase2002
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit5005
RAR-related orphan receptor gamma9009
ATAD5 protein, partial3003
Fumarate hydratase3003
USP1 protein, partial2002
PPM1D protein2002
TDP1 protein8008
GLI family zinc finger 38008
Thrombopoietin1001
AR protein9009
Smad34004
thyroid stimulating hormone receptor3003
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 36006
cytochrome P450 family 3 subfamily A polypeptide 47007
glucocorticoid receptor [Homo sapiens]9009
retinoic acid nuclear receptor alpha variant 1100010
retinoid X nuclear receptor alpha7007
estrogen-related nuclear receptor alpha9009
farnesoid X nuclear receptor6006
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha100010
polyprotein3003
67.9K protein3003
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma6006
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
IDH13003
euchromatic histone-lysine N-methyltransferase 23003
aryl hydrocarbon receptor5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)4004
nuclear receptor subfamily 1, group I, member 23003
cytochrome P450 2D6 isoform 11001
nuclear receptor subfamily 0 group B member 10101
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor3003
chromobox protein homolog 12002
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 23003
thyroid hormone receptor beta isoform 29009
atrial natriuretic peptide receptor 2 precursor1001
flap endonuclease 11001
ras-related protein Rab-9A1001
steroidogenic factor 10101
nuclear factor erythroid 2-related factor 2 isoform 16006
geminin6006
peripheral myelin protein 221001
cytochrome P450 3A4 isoform 13003
muscleblind-like protein 1 isoform 12002
caspase-1 isoform alpha precursor1001
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)1001
lamin isoform A-delta103003
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi3003
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40707
Solute carrier family 22 member 30101
Voltage-dependent calcium channel gamma-2 subunit5005
Bile salt export pump0808
Interferon beta9009
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0001
Tubulin beta-4A chain0225
Cellular tumor antigen p538008
ATP-dependent translocase ABCB10101
Tubulin beta chain0225
ATP-dependent translocase ABCB10203
Cytochrome P450 3A40101
Tubulin alpha-3C chain0225
Serine/threonine-protein kinase pim-10101
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Glutamate receptor 25005
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
ATP-dependent translocase ABCB10101
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Histamine H2 receptor3003
Nuclear receptor ROR-gamma2002
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0202
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
GABA theta subunit3003
CREB-binding protein1001
Canalicular multispecific organic anion transporter 10707
ATPase family AAA domain-containing protein 54004
Ataxin-24004
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Gamma-aminobutyric acid receptor subunit epsilon3003
Tubulin beta-1 chain0225
ATP-dependent phosphofructokinase2002
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 0101
G5005
bromodomain adjacent to zinc finger domain 2B3003
Bile salt export pump0101
HLA class I histocompatibility antigen, B alpha chain 5005
Myeloperoxidase0101
Dihydrofolate reductase0101
5-hydroxytryptamine receptor 60101
Inositol hexakisphosphate kinase 15005
cytochrome P450 2C9, partial5005
Vasopressin V2 receptor0112
Oxytocin receptor0011
Vasopressin V1a receptor0112
Vasopressin V1b receptor0112
Translocator protein0101
Vasopressin V2 receptor 0112
glp-1 receptor, partial1001
caspase 7, apoptosis-related cysteine protease1001
progesterone receptor4004
cytochrome P450 2D62002
caspase-31001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
potassium voltage-gated channel subfamily H member 2 isoform d3003
heat shock protein beta-15005
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Alpha-synuclein1102
Spike glycoprotein3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, JmjC domain-containing histone demethylation protein 3A2002
phosphopantetheinyl transferase1001
Microtubule-associated protein tau2002
EWS/FLI fusion protein4004
nonstructural protein 11001
arylsulfatase A1001
thyroid stimulating hormone receptor2002
serine-protein kinase ATM isoform a1001
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 12002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
mitogen-activated protein kinase 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
serine/threonine-protein kinase mTOR isoform 12002
nuclear receptor ROR-gamma isoform 11001
survival motor neuron protein isoform d1001
M-phase phosphoprotein 81001
histone acetyltransferase KAT2A isoform 11001
5-hydroxytryptamine receptor 40213
Fatty acid-binding protein, liver0213
Fatty acid-binding protein, liver0101
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor M30011
Muscarinic acetylcholine receptor M40011
Muscarinic acetylcholine receptor M50011
Adenosine receptor A30404
Muscarinic acetylcholine receptor M20011
Fatty acid-binding protein, intestinal0112
Beta-3 adrenergic receptor0202
Alpha-1B adrenergic receptor0404
Acetylcholinesterase0101
Peroxisome proliferator-activated receptor alpha0011
Sodium-dependent noradrenaline transporter 0202
Cruzipain0101
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
D(3) dopamine receptor0202
Peroxisome proliferator-activated receptor alpha0011
Peroxisome proliferator-activated receptor gamma0112
Peroxisome proliferator-activated receptor gamma0011
Alpha-1A adrenergic receptor0404
Disintegrin and metalloproteinase domain-containing protein 171001
Sodium-dependent dopamine transporter 0202
Peroxisome proliferator-activated receptor alpha0112
Sigma non-opioid intracellular receptor 10011
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain A, Cruzipain1001
aldehyde dehydrogenase 1 family, member A12002
regulator of G-protein signaling 42002
Parkin2002
Caspase-71001
vitamin D3 receptor isoform VDRA2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
caspase-31001
serine/threonine-protein kinase PLK12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)2002
Ornithine decarboxylase0001
Retinoic acid receptor alpha0101
Alpha-2B adrenergic receptor0202
Retinoic acid receptor gamma0101
Retinoic acid receptor beta0101
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0101
Retinoic acid receptor RXR-beta0101
Retinoic acid receptor RXR-gamma0101
Cellular retinoic acid-binding protein 10101
5-hydroxytryptamine receptor 2B0202
Cellular retinoic acid-binding protein 10011
Mitogen-activated protein kinase 140101
Rap guanine nucleotide exchange factor 41001
Olfactory receptor 51E20101
GALC protein1001
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
luciferase0001
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Cytochrome P450 2C9 0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
SMAD family member 21001
SMAD family member 31001
PINK11001
photoreceptor-specific nuclear receptor0101
Histone H2A.x1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
Insulin receptor 0101
Nuclear receptor subfamily 4 group A member 20011
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
TAR DNA-binding protein 431001
Sigma non-opioid intracellular receptor 10101
Solute carrier organic anion transporter family member 1B10101
Rap guanine nucleotide exchange factor 31001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
Albumin0011
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]