Page last updated: 2024-09-27

Anetoderma

Benign DERMATOSIS caused by a loss of dermal ELASTIC TISSUE resulting in localized sac-like areas of flaccid skin. It can be either primary (idiopathic) or secondary to other skin conditions, PENICILLAMINE use, or premature birth.

Synonyms(3)

Synonym
Anetoderma, Secondary
Anetoderma, Primary
Anetoderma

Research Excerpts

Overview

Excerpt	Reference
"Anetoderma is an uncommon disease characterized by multiple circumscribed atrophic, herniated skin lesions on trunk, thighs and upper arms caused by loss of elastic fibers."	( Hetzer, S; Homey, B; Reifenberger, J; Strunk, T, 2011)
"Anetoderma is a skin disorder characterized by a focal loss of dermal elastic tissue whereby patients present with soft, depressible lesions."	( Ross, NA; Saedi, N; Wang, K, 2016)

Treatment

Excerpt	Reference
"Our patient with biopsy proven anetoderma received 3 treatments with a combination of 595-nm PDL and 1550-nm NAFL spaced 3 weeks apart."	( Ross, NA; Saedi, N; Wang, K, 2016)

Research

Studies (13)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (15.38)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	9 (69.23)	28.8240
2020's	2 (15.38)	9.53

Drug	Relationship Strength	Studies
dalteparin	low	1
dapsone	low	1
fenofibrate	low	1
prednisolone	low	1
potassium hydroxide	low	1
simvastatin	low	1
itraconazole	low	1
elastin	low	2
isotretinoin	low	1
vitamin k 1	low	1
deamino arginine vasopressin	low	1
gadolinium dtpa	low	1
warfarin	low	1

Protein Targets (287)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, Beta-lactamase	3	0	0	3
Chain A, Ferritin light chain	4	0	0	4
Luciferase	3	0	0	3
interleukin 8	2	0	0	2
endonuclease IV	2	0	0	2
PAX8	0	0	0	1
thioredoxin reductase	2	0	0	2
pregnane X receptor	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
RAR-related orphan receptor gamma	9	0	0	9
ATAD5 protein, partial	3	0	0	3
Fumarate hydratase	3	0	0	3
USP1 protein, partial	2	0	0	2
PPM1D protein	2	0	0	2
TDP1 protein	8	0	0	8
GLI family zinc finger 3	8	0	0	8
Thrombopoietin	1	0	0	1
AR protein	9	0	0	9
Smad3	4	0	0	4
thyroid stimulating hormone receptor	3	0	0	3
estrogen receptor 2 (ER beta)	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
glucocorticoid receptor [Homo sapiens]	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
retinoid X nuclear receptor alpha	7	0	0	7
estrogen-related nuclear receptor alpha	9	0	0	9
farnesoid X nuclear receptor	6	0	0	6
pregnane X nuclear receptor	7	0	0	7
estrogen nuclear receptor alpha	10	0	0	10
polyprotein	3	0	0	3
67.9K protein	3	0	0	3
glucocerebrosidase	1	0	0	1
peroxisome proliferator-activated receptor delta	6	0	0	6
peroxisome proliferator activated receptor gamma	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
IDH1	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
activating transcription factor 6	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	3	0	0	3
chromobox protein homolog 1	2	0	0	2
thyroid hormone receptor beta isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
thyroid hormone receptor beta isoform 2	9	0	0	9
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
flap endonuclease 1	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
steroidogenic factor 1	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
geminin	6	0	0	6
peripheral myelin protein 22	1	0	0	1
cytochrome P450 3A4 isoform 1	3	0	0	3
muscleblind-like protein 1 isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	1	0	0	1
lamin isoform A-delta10	3	0	0	3
neuropeptide S receptor isoform A	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	7
Solute carrier family 22 member 3	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Bile salt export pump	0	8	0	8
Interferon beta	9	0	0	9
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
Cellular tumor antigen p53	8	0	0	8
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	2	0	3
Cytochrome P450 3A4	0	1	0	1
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
Glutamate receptor 2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
ATP-dependent translocase ABCB1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Histamine H2 receptor	3	0	0	3
Nuclear receptor ROR-gamma	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
GABA theta subunit	3	0	0	3
CREB-binding protein	1	0	0	1
Canalicular multispecific organic anion transporter 1	0	7	0	7
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
Tubulin beta-1 chain	0	2	2	5
ATP-dependent phosphofructokinase	2	0	0	2
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
G	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
Bile salt export pump	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Myeloperoxidase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Inositol hexakisphosphate kinase 1	5	0	0	5
cytochrome P450 2C9, partial	5	0	0	5
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
glp-1 receptor, partial	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
progesterone receptor	4	0	0	4
cytochrome P450 2D6	2	0	0	2
caspase-3	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
heat shock protein beta-1	5	0	0	5
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Alpha-synuclein	1	1	0	2
Spike glycoprotein	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
phosphopantetheinyl transferase	1	0	0	1
Microtubule-associated protein tau	2	0	0	2
EWS/FLI fusion protein	4	0	0	4
nonstructural protein 1	1	0	0	1
arylsulfatase A	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
5-hydroxytryptamine receptor 4	0	2	1	3
Fatty acid-binding protein, liver	0	2	1	3
Fatty acid-binding protein, liver	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Adenosine receptor A3	0	4	0	4
Muscarinic acetylcholine receptor M2	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	4	0	4
Acetylcholinesterase	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Cruzipain	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	1	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Alpha-1A adrenergic receptor	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Peroxisome proliferator-activated receptor alpha	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Chain A, Cruzipain	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
regulator of G-protein signaling 4	2	0	0	2
Parkin	2	0	0	2
Caspase-7	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
caspase-3	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	2	0	0	2
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Cellular retinoic acid-binding protein 1	0	0	1	1
Mitogen-activated protein kinase 14	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Olfactory receptor 51E2	0	1	0	1
GALC protein	1	0	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	1	8
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Cytochrome P450 2C9	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
Estrogen receptor beta	0	2	0	2
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
PINK1	1	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
Histone H2A.x	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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