glycyrin has been researched along with licoricidin* in 2 studies
2 other study(ies) available for glycyrin and licoricidin
| Article | Year |
|---|---|
Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification.
Phytochemical investigation of a supercritical fluid extract of Glycyrrhiza uralensis has led to the isolation of 20 known isoflavonoids and coumarins, and glycycarpan (7), a new pterocarpan. The presence of two isoflavan-quinones, licoriquinone A (8) and licoriquinone B (9), in a fraction subjected to gel filtration on Sephadex LH-20 is due to suspected metal-catalyzed oxidative degradation of licoricidin (1) and licorisoflavan A (2). The major compounds in the extract, as well as 8, were evaluated for their ability to inhibit the growth of several major oral pathogens. Compounds 1 and 2 showed the most potent antibacterial activities, causing a marked growth inhibition of the cariogenic species Streptococcus mutans and Streptococcus sobrinus at 10 μg/mL and the periodontopathogenic species Porphyromonas gingivalis (at 5 μg/mL) and Prevotella intermedia (at 5 μg/mL for 1 and 2.5 μg/mL for 2). Only 1 moderately inhibited growth of Fusobacterium nucleatum at the highest concentration tested (10 μg/mL). Topics: Anti-Bacterial Agents; Benzopyrans; Coumarins; Dose-Response Relationship, Drug; Fusobacterium nucleatum; Germany; Glycyrrhiza uralensis; Humans; Isoflavones; Microbial Sensitivity Tests; Porphyromonas gingivalis; Pterocarpans; Quinones; Streptococcus mutans; Streptococcus sobrinus | 2011 |
Antibacterial compounds of licorice against upper airway respiratory tract pathogens.
The antibacterial activity of compounds obtained from licorice was measured against upper airway respiratory tract bacteria such as Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis. Among the tested compounds, licoricidin exhibited the highest activity against all tested microorganisms with an MIC of 12.5 microg/mL. Three coumarin derivatives, glycyrol, glycyrin and glycycoumarin also showed antibacterial activity. Topics: Anti-Bacterial Agents; Bacteria; Benzopyrans; Cells, Cultured; Coumarins; Enzyme Inhibitors; Glycyrrhetinic Acid; Glycyrrhiza; Glycyrrhizic Acid; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Moraxella catarrhalis; Plant Extracts; Plant Roots; Respiratory Tract Infections; Streptococcus pyogenes | 2001 |