glycyrin and Diabetes-Mellitus--Type-2

glycyrin has been researched along with Diabetes-Mellitus--Type-2* in 1 studies

Other Studies

1 other study(ies) available for glycyrin and Diabetes-Mellitus--Type-2

Article	Year
Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice. Bioorganic & medicinal chemistry letters, 2003, Dec-15, Volume: 13, Issue:24 The EtOAc extract of licorice (Glycyrrhiza uralensis roots) exhibited considerable PPAR-gamma ligand-binding activity. Bioassay-guided fractionation of the extract using a GAL-4-PPAR-gamma chimera assay method resulted in the isolation of two isoflavenes, one of which is a new compound named dehydroglyasperin D, an isoflavan, two 3-arylcoumarins, and an isoflavanone as the PPAR-gamma ligand-binding active ingredients of licorice. The isoprenyl group at C-6 and the C-2' hydroxyl group in the aromatic ring-C part in the isoflavan, isoflavene, or arylcoumarin skeleton were found to be the structural requirements for PPAR-gamma ligand-binding activity. Glycyrin, one of the main PPAR-gamma ligands of licorice, significantly decreased the blood glucose levels of genetically diabetic KK-A(y) mice. Topics: Animals; Binding Sites; Cell Line; Chlorocebus aethiops; Coumarins; Diabetes Mellitus, Type 2; Glycyrrhiza; Hypoglycemic Agents; Ligands; Mice; Mice, Mutant Strains; Phenols; Phytotherapy; Pioglitazone; Plant Extracts; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Structure-Activity Relationship; Thiazolidinediones; Transcription Factors	2003

Article

Year

Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice.

Bioorganic & medicinal chemistry letters, 2003, Dec-15, Volume: 13, Issue:24

The EtOAc extract of licorice (Glycyrrhiza uralensis roots) exhibited considerable PPAR-gamma ligand-binding activity. Bioassay-guided fractionation of the extract using a GAL-4-PPAR-gamma chimera assay method resulted in the isolation of two isoflavenes, one of which is a new compound named dehydroglyasperin D, an isoflavan, two 3-arylcoumarins, and an isoflavanone as the PPAR-gamma ligand-binding active ingredients of licorice. The isoprenyl group at C-6 and the C-2' hydroxyl group in the aromatic ring-C part in the isoflavan, isoflavene, or arylcoumarin skeleton were found to be the structural requirements for PPAR-gamma ligand-binding activity. Glycyrin, one of the main PPAR-gamma ligands of licorice, significantly decreased the blood glucose levels of genetically diabetic KK-A(y) mice.

Topics: Animals; Binding Sites; Cell Line; Chlorocebus aethiops; Coumarins; Diabetes Mellitus, Type 2; Glycyrrhiza; Hypoglycemic Agents; Ligands; Mice; Mice, Mutant Strains; Phenols; Phytotherapy; Pioglitazone; Plant Extracts; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Structure-Activity Relationship; Thiazolidinediones; Transcription Factors

2003