Page last updated: 2024-11-12
tubocapsanolide a
Description
tubocapsanolide A: withanolide Tubocapsanolide A inhibits proliferation of human lung cancer cells structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
tubocapsanolide A : A withanolide that is 5beta,6beta:16alpha,17alpha-diepoxywitha-2,24-dienolide substituted by a hydroxy group at position 4 and an oxo group at position 1. Isolated from Tubocapsicum anomalum, it exhibits cytotoxic activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|
| Tubocapsicum | genus | [no description available] | Solanaceae | A plant family of the order SOLANALES, class MAGNOLIOPSIDA. Among the most noted are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.[MeSH] |
| Tubocapsicum anomalum | species | [no description available] | Solanaceae | A plant family of the order SOLANALES, class MAGNOLIOPSIDA. Among the most noted are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.[MeSH] |
Cross-References
Synonyms (7)
| Synonym |
|---|
| tubocapsanolide a |
| CHEMBL227900 |
| chebi:66325 , |
| 5beta,6beta:16alpha,17alpha-diepoxy-4beta-hydroxy-1-oxo-witha-2,24-dienolide |
| (4beta,5beta,6beta,16alpha,17alpha)-17-{(1r)-1-[(2r)-4,5-dimethyl-6-oxo-3,6-dihydro-2h-pyran-2-yl]ethyl}-4-hydroxy-5,6:16,17-diepoxyandrost-2-en-1-one |
| Q27134872 |
| (1s,2r,6s,7r,9r,11s,12s,14r,16s,17s)-16-[(1r)-1-[(2r)-4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-6-hydroxy-2,17-dimethyl-8,15-dioxahexacyclo[9.8.0.02,7.07,9.012,17.014,16]nonadec-4-en-3-one |
Roles (2)
| Role | Description |
|---|
| antineoplastic agent | A substance that inhibits or prevents the proliferation of neoplasms. |
| NF-kappaB inhibitor | An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (7)
| Class | Description |
|---|
| delta-lactone | A lactone having a six-membered lactone ring. |
| 4-hydroxy steroid | Any steroid bearing a 4-hydroxy substituent. |
| enone | An alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position. |
| ergostanoid | |
| secondary alcohol | A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it. |
| withanolide | Any steroid lactone that is a C28 steroid with a modified side chain forming a lactone ring and its substituted derivatives. |
| epoxy steroid | Any steroid whose structure includes an epoxy group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Bioassays (6)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID286448 | Cytotoxicity against human Hep3B cells by MTT method | 2007 | Journal of natural products, May, Volume: 70, Issue:5
| Cytotoxic withanolides from Tubocapsicum anomalum. |
| AID286447 | Cytotoxicity against human HepG2 cells by MTT method | 2007 | Journal of natural products, May, Volume: 70, Issue:5
| Cytotoxic withanolides from Tubocapsicum anomalum. |
| AID286451 | Cytotoxicity against human MDA-MB-231 cells by MTT method | 2007 | Journal of natural products, May, Volume: 70, Issue:5
| Cytotoxic withanolides from Tubocapsicum anomalum. |
| AID286449 | Cytotoxicity against human MCF7 cells by MTT method | 2007 | Journal of natural products, May, Volume: 70, Issue:5
| Cytotoxic withanolides from Tubocapsicum anomalum. |
| AID286450 | Cytotoxicity against human A549 cells by MTT method | 2007 | Journal of natural products, May, Volume: 70, Issue:5
| Cytotoxic withanolides from Tubocapsicum anomalum. |
| AID286452 | Cytotoxicity against human MRC5 cells by MTT method | 2007 | Journal of natural products, May, Volume: 70, Issue:5
| Cytotoxic withanolides from Tubocapsicum anomalum. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.70
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.70 (24.57) | | Research Supply Index | 1.95 (2.92) | | Research Growth Index | 4.65 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |