| Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
|---|
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | 3 | 0 | 0 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | 2 | 0 | 0 | 2 |
| Chain A, Ferritin light chain | 5 | 0 | 0 | 5 |
| interleukin 8 | 2 | 0 | 0 | 2 |
| acetylcholinesterase | 1 | 0 | 0 | 1 |
| thioredoxin reductase | 3 | 0 | 0 | 3 |
| phosphopantetheinyl transferase | 3 | 0 | 0 | 3 |
| RAR-related orphan receptor gamma | 7 | 0 | 0 | 7 |
| SMAD family member 2 | 4 | 0 | 0 | 4 |
| ATAD5 protein, partial | 3 | 0 | 0 | 3 |
| Fumarate hydratase | 1 | 0 | 0 | 1 |
| SMAD family member 3 | 4 | 0 | 0 | 4 |
| TDP1 protein | 6 | 0 | 0 | 6 |
| GLI family zinc finger 3 | 5 | 0 | 0 | 5 |
| Microtubule-associated protein tau | 4 | 0 | 0 | 4 |
| AR protein | 6 | 0 | 0 | 6 |
| thioredoxin glutathione reductase | 3 | 0 | 0 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | 5 | 0 | 0 | 5 |
| EWS/FLI fusion protein | 2 | 0 | 0 | 2 |
| glucocorticoid receptor [Homo sapiens] | 5 | 0 | 0 | 5 |
| retinoic acid nuclear receptor alpha variant 1 | 4 | 0 | 0 | 4 |
| retinoid X nuclear receptor alpha | 5 | 0 | 0 | 5 |
| estrogen-related nuclear receptor alpha | 6 | 0 | 0 | 6 |
| farnesoid X nuclear receptor | 4 | 0 | 0 | 4 |
| pregnane X nuclear receptor | 5 | 0 | 0 | 5 |
| estrogen nuclear receptor alpha | 6 | 0 | 0 | 6 |
| G | 3 | 0 | 0 | 3 |
| polyprotein | 1 | 0 | 0 | 1 |
| P53 | 1 | 0 | 0 | 1 |
| peroxisome proliferator-activated receptor delta | 4 | 0 | 0 | 4 |
| peroxisome proliferator activated receptor gamma | 5 | 0 | 0 | 5 |
| arylsulfatase A | 1 | 0 | 0 | 1 |
| IDH1 | 3 | 0 | 0 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | 5 | 0 | 0 | 5 |
| aryl hydrocarbon receptor | 3 | 0 | 0 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | 5 | 0 | 0 | 5 |
| thyroid stimulating hormone receptor | 2 | 0 | 0 | 2 |
| activating transcription factor 6 | 1 | 0 | 0 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | 3 | 0 | 0 | 3 |
| Histone H2A.x | 2 | 0 | 0 | 2 |
| Bloom syndrome protein isoform 1 | 2 | 0 | 0 | 2 |
| peripheral myelin protein 22 isoform 1 | 1 | 0 | 0 | 1 |
| hemoglobin subunit beta | 1 | 0 | 0 | 1 |
| cellular tumor antigen p53 isoform a | 3 | 0 | 0 | 3 |
| thyroid hormone receptor beta isoform 2 | 5 | 0 | 0 | 5 |
| heat shock protein beta-1 | 1 | 0 | 0 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | 5 | 0 | 0 | 5 |
| DNA polymerase iota isoform a (long) | 5 | 0 | 0 | 5 |
| geminin | 5 | 0 | 0 | 5 |
| peripheral myelin protein 22 | 3 | 0 | 0 | 3 |
| survival motor neuron protein isoform d | 2 | 0 | 0 | 2 |
| cytochrome P450 3A4 isoform 1 | 3 | 0 | 0 | 3 |
| M-phase phosphoprotein 8 | 2 | 0 | 0 | 2 |
| muscleblind-like protein 1 isoform 1 | 3 | 0 | 0 | 3 |
| muscarinic acetylcholine receptor M1 | 1 | 0 | 0 | 1 |
| lamin isoform A-delta10 | 5 | 0 | 0 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | 3 | 0 | 0 | 3 |
| ATP-binding cassette sub-family C member 3 | 0 | 4 | 0 | 4 |
| Multidrug resistance-associated protein 4 | 0 | 4 | 0 | 5 |
| Bile salt export pump | 0 | 2 | 0 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | 5 | 0 | 0 | 5 |
| Bile salt export pump | 0 | 5 | 0 | 5 |
| Interferon beta | 4 | 0 | 0 | 4 |
| HLA class I histocompatibility antigen, B alpha chain | 3 | 0 | 0 | 3 |
| Cellular tumor antigen p53 | 5 | 0 | 0 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | 3 | 0 | 0 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | 3 | 0 | 0 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | 3 | 0 | 0 | 3 |
| Glutamate receptor 2 | 5 | 0 | 0 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | 3 | 0 | 0 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | 3 | 0 | 0 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | 3 | 0 | 0 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | 3 | 0 | 0 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | 3 | 0 | 0 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | 3 | 0 | 0 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | 3 | 0 | 0 | 3 |
| Nuclear receptor ROR-gamma | 2 | 0 | 0 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | 3 | 0 | 0 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | 3 | 0 | 0 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | 3 | 0 | 0 | 3 |
| GABA theta subunit | 3 | 0 | 0 | 3 |
| Inositol hexakisphosphate kinase 1 | 3 | 0 | 0 | 3 |
| Canalicular multispecific organic anion transporter 1 | 0 | 4 | 0 | 4 |
| ATPase family AAA domain-containing protein 5 | 4 | 0 | 0 | 4 |
| Ataxin-2 | 4 | 0 | 0 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | 3 | 0 | 0 | 3 |
| Protein-arginine deiminase type-4 | 0 | 2 | 0 | 2 |
| cytochrome P450 2C9, partial | 3 | 0 | 0 | 3 |
| Chain A, Beta-lactamase | 4 | 0 | 0 | 4 |
| GALC protein | 1 | 0 | 0 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 1 | 0 | 0 | 1 |
| PINK1 | 2 | 0 | 0 | 2 |
| progesterone receptor | 5 | 0 | 0 | 5 |
| Parkin | 2 | 0 | 0 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | 4 | 0 | 0 | 4 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | 2 | 0 | 0 | 2 |
| chromobox protein homolog 1 | 4 | 0 | 0 | 4 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | 1 | 0 | 0 | 1 |
| Glucocorticoid receptor | 0 | 6 | 2 | 13 |
| Glycine receptor subunit alpha-1 | 0 | 6 | 0 | 6 |
| Androgen receptor | 0 | 5 | 0 | 5 |
| Glycine receptor subunit beta | 0 | 6 | 0 | 6 |
| Glycine receptor subunit alpha-2 | 0 | 6 | 0 | 6 |
| Glycine receptor subunit alpha-3 | 0 | 6 | 0 | 6 |
| Cytochrome P450 2C19 | 0 | 1 | 0 | 1 |
| Spike glycoprotein | 3 | 0 | 0 | 3 |
| Chain A, Cruzipain | 1 | 0 | 0 | 1 |
| pregnane X receptor | 2 | 0 | 0 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | 2 | 0 | 0 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | 2 | 0 | 0 | 2 |
| nonstructural protein 1 | 3 | 0 | 0 | 3 |
| nuclear receptor subfamily 1, group I, member 2 | 2 | 0 | 0 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | 3 | 0 | 0 | 3 |
| transcriptional regulator ERG isoform 3 | 2 | 0 | 0 | 2 |
| neuropeptide S receptor isoform A | 1 | 0 | 0 | 1 |
| Estrogen receptor | 0 | 3 | 1 | 4 |
| Sex hormone-binding globulin | 0 | 0 | 1 | 1 |
| Progesterone receptor | 0 | 4 | 1 | 6 |
| Mineralocorticoid receptor | 0 | 3 | 1 | 4 |
| Androgen receptor | 0 | 4 | 2 | 6 |
| Androgen receptor | 0 | 0 | 1 | 1 |
| Histamine H2 receptor | 0 | 2 | 0 | 2 |
| 5-hydroxytryptamine receptor 1B | 0 | 1 | 0 | 1 |
| Alpha-synuclein | 1 | 0 | 0 | 1 |
| Aldo-keto reductase family 1 member C3 | 0 | 1 | 0 | 1 |
| Aldo-keto reductase family 1 member C2 | 0 | 1 | 0 | 1 |
| Guanine nucleotide-binding protein G | 2 | 0 | 0 | 2 |
| Aldo-keto reductase family 1 member C1 | 0 | 1 | 0 | 1 |
| Estrogen receptor beta | 0 | 3 | 1 | 4 |
| Chain B, DIHYDROFOLATE REDUCTASE | 0 | 0 | 1 | 1 |
| Chain B, DIHYDROFOLATE REDUCTASE | 0 | 0 | 1 | 1 |
| Chain B, DIHYDROFOLATE REDUCTASE | 0 | 0 | 1 | 1 |
| Chain A, HADH2 protein | 1 | 0 | 0 | 1 |
| Chain B, HADH2 protein | 1 | 0 | 0 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | 1 | 0 | 0 | 1 |
| acid sphingomyelinase | 1 | 0 | 0 | 1 |
| dopamine D1 receptor | 1 | 0 | 0 | 1 |
| ClpP | 1 | 0 | 0 | 1 |
| 15-lipoxygenase, partial | 1 | 0 | 0 | 1 |
| USP1 protein, partial | 2 | 0 | 0 | 2 |
| estrogen receptor 2 (ER beta) | 2 | 0 | 0 | 2 |
| 67.9K protein | 1 | 0 | 0 | 1 |
| Thymidylate synthase | 0 | 1 | 0 | 1 |
| alpha-galactosidase | 1 | 0 | 0 | 1 |
| Thymidylate synthase | 0 | 1 | 0 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | 1 | 0 | 0 | 1 |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | 1 | 0 | 0 | 1 |
| vitamin D3 receptor isoform VDRA | 3 | 0 | 0 | 3 |
| importin subunit beta-1 isoform 1 | 1 | 0 | 0 | 1 |
| DNA polymerase beta | 1 | 0 | 0 | 1 |
| nuclear receptor coactivator 1 isoform 1 [Homo sapiens] | 0 | 1 | 0 | 1 |
| flap endonuclease 1 | 1 | 0 | 0 | 1 |
| snurportin-1 | 1 | 0 | 0 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 1 | 0 | 0 | 1 |
| DNA polymerase eta isoform 1 | 1 | 0 | 0 | 1 |
| transactivating tegument protein VP16 [Human herpesvirus 1] | 0 | 1 | 0 | 1 |
| DNA polymerase kappa isoform 1 | 1 | 0 | 0 | 1 |
| histone acetyltransferase KAT2A isoform 1 | 2 | 0 | 0 | 2 |
| caspase-1 isoform alpha precursor | 1 | 0 | 0 | 1 |
| nuclear receptor coactivator 3 isoform a | 0 | 1 | 0 | 1 |
| Toll-like receptor 4 | 0 | 1 | 0 | 1 |
| Fatty-acid amide hydrolase 1 | 0 | 1 | 0 | 1 |
| ATP-binding cassette sub-family C member 3 | 0 | 1 | 0 | 2 |
| Dihydrofolate reductase | 0 | 2 | 0 | 3 |
| Dihydrofolate reductase | 0 | 2 | 0 | 3 |
| Dihydrofolate reductase | 0 | 1 | 0 | 1 |
| Dihydrofolate reductase | 0 | 1 | 0 | 1 |
| Dihydrofolate reductase | 0 | 1 | 0 | 1 |
| Dihydrofolate reductase | 0 | 2 | 0 | 3 |
| Thymidylate synthase | 0 | 1 | 0 | 1 |
| Tyrosine-protein kinase ABL1 | 0 | 0 | 1 | 1 |
| Carbonic anhydrase 2 | 0 | 0 | 1 | 1 |
| Thymidylate synthase | 0 | 2 | 0 | 2 |
| Integrin beta-3 | 2 | 0 | 0 | 2 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | 0 | 1 | 0 | 1 |
| Thymidylate synthase | 0 | 2 | 0 | 2 |
| Integrin alpha-IIb | 2 | 0 | 0 | 2 |
| 5-hydroxytryptamine receptor 2C | 0 | 1 | 0 | 2 |
| High mobility group protein B1 | 0 | 0 | 1 | 1 |
| Dihydrofolate reductase | 0 | 1 | 0 | 1 |
| Thymidylate synthase | 0 | 1 | 0 | 1 |
| Dihydrofolate reductase | 0 | 2 | 2 | 4 |
| Glucose-6-phosphate 1-dehydrogenase | 0 | 1 | 0 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | 0 | 1 | 0 | 1 |
| Folate receptor beta | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 2A | 0 | 1 | 0 | 1 |
| Cytochrome P450 11B1, mitochondrial | 0 | 1 | 0 | 1 |
| Folate receptor alpha | 0 | 1 | 0 | 1 |
| Dihydrofolate reductase | 0 | 2 | 0 | 2 |
| Histidine decarboxylase | 0 | 1 | 0 | 1 |
| Trifunctional purine biosynthetic protein adenosine-3 | 0 | 1 | 0 | 1 |
| Cyclin-dependent kinase 2 | 0 | 0 | 1 | 1 |
| Bifunctional purine biosynthesis protein ATIC | 0 | 2 | 0 | 2 |
| Multidrug resistance-associated protein 1 | 0 | 0 | 0 | 1 |
| Delta-type opioid receptor | 0 | 1 | 0 | 1 |
| Mu-type opioid receptor | 0 | 1 | 0 | 1 |
| Kappa-type opioid receptor | 0 | 1 | 0 | 1 |
| Reduced folate transporter | 0 | 2 | 0 | 2 |
| Folylpolyglutamate synthase, mitochondrial | 0 | 1 | 0 | 3 |
| 6-phosphogluconate dehydrogenase, decarboxylating | 0 | 1 | 0 | 1 |
| Caspase-7 | 1 | 0 | 0 | 1 |
| Solute carrier organic anion transporter family member 1A3 | 0 | 0 | 0 | 1 |
| Dihydrofolate reductase | 0 | 1 | 0 | 1 |
| Pteridine reductase 1 | 0 | 1 | 0 | 1 |
| Folylpolyglutamate synthase, mitochondrial | 0 | 1 | 0 | 3 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | 0 | 1 | 0 | 1 |
| TAR DNA-binding protein 43 | 2 | 0 | 0 | 2 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | 0 | 1 | 0 | 1 |
| Solute carrier family 22 member 6 | 0 | 0 | 0 | 1 |
| Canalicular multispecific organic anion transporter 1 | 0 | 1 | 0 | 2 |
| Trifunctional purine biosynthetic protein adenosine-3 | 0 | 1 | 0 | 1 |
| Solute carrier family 22 member 20 | 0 | 1 | 0 | 1 |
| Dihydrofolate reductase | 0 | 1 | 0 | 1 |
| Solute carrier family 22 member 8 | 0 | 0 | 0 | 1 |
| Solute carrier family 22 member 6 | 0 | 1 | 0 | 1 |
| Dihydrofolate reductase | 0 | 1 | 0 | 1 |
| ATP-binding cassette sub-family C member 11 | 0 | 0 | 0 | 1 |
| Proton-coupled folate transporter | 0 | 1 | 0 | 1 |
| Multidrug resistance associated protein | 0 | 1 | 0 | 2 |
| Solute carrier organic anion transporter family member 1B3 | 0 | 0 | 0 | 1 |
| Solute carrier family 22 member 11 | 0 | 0 | 0 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | 0 | 0 | 0 | 1 |
| ATP-dependent phosphofructokinase | 1 | 0 | 0 | 1 |
| Luciferase | 1 | 0 | 0 | 1 |
| bromodomain adjacent to zinc finger domain 2B | 1 | 0 | 0 | 1 |
| mitogen-activated protein kinase 1 | 1 | 0 | 0 | 1 |
| luciferase | 0 | 0 | 0 | 1 |
| hypoxia-inducible factor 1 alpha subunit | 1 | 0 | 0 | 1 |
| Fatty acid-binding protein, liver | 0 | 1 | 0 | 1 |
| Glucocorticoid receptor | 0 | 1 | 1 | 2 |
| Glucocorticoid receptor | 0 | 0 | 1 | 1 |
| Corticosteroid-binding globulin | 0 | 1 | 0 | 1 |
| Cytochrome P450 2C9 | 0 | 1 | 0 | 1 |
| Glutamine synthetase | 0 | 0 | 1 | 1 |
| Histamine H1 receptor | 0 | 0 | 1 | 1 |
| Prostaglandin G/H synthase 2 | 0 | 1 | 0 | 1 |
| Nociceptin receptor | 0 | 0 | 1 | 1 |
| Cytochrome P450 2J2 | 0 | 1 | 0 | 1 |
| glp-1 receptor, partial | 1 | 0 | 0 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 1 | 0 | 0 | 1 |
| thyroid hormone receptor beta isoform a | 1 | 0 | 0 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | 0 | 0 | 0 | 1 |
| nuclear receptor ROR-gamma isoform 1 | 1 | 0 | 0 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | 1 | 0 | 0 | 1 |
| Cytochrome P450 3A4 | 0 | 1 | 0 | 1 |
| Histamine H2 receptor | 1 | 0 | 0 | 1 |
| heat shock protein 90, putative | 0 | 0 | 0 | 1 |
| Rap guanine nucleotide exchange factor 3 | 1 | 0 | 0 | 1 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |