Compounds > manool
Page last updated: 2024-12-10

manool

Description

manool: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

manool : A labdane diterpenoid in which the labdane skeleton has double bonds at positions 8(17) and 14 and carries an R-hydroxy group at position 13. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID3034394
CHEMBL ID4162501
CHEBI ID76945
SCHEMBL ID12658773
MeSH IDM0462748

Synonyms (30)

Synonym
nsc165961
manool
nsc-165961
(3r)-5-[(1s,4as,8as)-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]-3-methylpent-1-en-3-ol
at5pj0pv00 ,
(+)-manool
(3r)-5-[(1s,4as,8as)-5,5,8a-trimethyl-2-methylene-decalin-1-yl]-3-methyl-pent-1-en-3-ol
labda-8 (20),14-dien-13-ol, (13r)-
1-naphthalenepropanol, .alpha.-ethenyldecahydro-.alpha.,5,5,8a-tetramethyl-2-methylene-, (4as)-
labda-8(17),14-dien-13(r)-ol
(5s,9s,10s,13r)-labda-8(17),14-dien-13-ol
CHEBI:76945
(13r)-manool
(13r)-labda-8(27),14-dien-13-ol
(13r)-labda-8(20),14-dien-13-ol
(3r)-3-methyl-5-[(1s,4as,8as)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl]pent-1-en-3-ol
CCG-208417
(3r)-3-methyl-5-[(1r,4ar,8ar)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]pent-1-en-3-ol
SCHEMBL12658773
1-naphthalenepropanol, .alpha.-ethenyldecahydro-.alpha.,5,5,8a-tetramethyl-2-methylene-, (.alpha.r,1s,4as,8as)-
SR-05000002258-2
sr-05000002258
(r)-3-methyl-5-((1s,4as,8as)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl)pent-1-en-3-ol
Q15726184
(.alpha.r,1s,4as,8as)-.alpha.-ethenyldecahydro-.alpha.,5,5,8a-tetramethyl-2-methylene-1-naphthalenepropanol
MS-24149
CHEMBL4162501
CS-0132370
HY-N1039A
(3r)-5-[(1s,4as,8as)-5,5,8a-trimethyl-2-methylidene-decahydronaphthalen-1-yl]-3-methylpent-1-en-3-ol

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" A gradual increase in manool doses did not cause a proportional reduction of preneoplastic lesions, thus demonstrating the absence of a dose-response relationship."( Manool, a diterpene from Salvia officinalis, exerts preventive effects on chromosomal damage and preneoplastic lesions.
Esperandim, TR; Fernandes, G; Furtado, RA; Nicolella, HD; Ozelin, SD; Ribeiro, AB; Rinaldi-Neto, F; Senedese, JM; Tavares, DC; Veneziani, RCS, 2021)		2.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
labdane diterpenoidAny diterpenoid with a labdane skeleton.
tertiary alcoholA tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (46)

Assay IDTitleYearJournalArticle
AID1889591Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as reduction in spleen weight at 20 mg/kg, sc administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889566Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in body weight at 20 to 40 mg/kg, po administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889564Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in number of mitotic figures at 20 mg/kg, po administered once daily for consecutive 5 days in presence of cisplatin by H and E staining microscopic analysis2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889574Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 20 mg/kg, po for consecutive 5 days (Rvb = 6.00 +/-1.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889562Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in mitotic figures at 40 mg/kg, ip administered once daily for consecutive 5 days by H and E staining microscopic analysis2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889590Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as reduction in spleen weight at 20 mg/kg, po administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889575Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 40 mg/kg, po for consecutive 5 days (Rvb = 6.00 +/-1.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889559Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 40 mg/kg, sc administered once daily for consecutive 5 days relative to control (Rvb = 50.7%)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889588Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in kidney weight at 20 to 40 mg/kg, po administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889580Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 20 mg/kg, po for consecutive 5 days (Rvb = 0.90 +/-0.04)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889558Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, sc administered once daily for consecutive 5 days relative to control (Rvb = 50.7%)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889578Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 20 mg/kg, ip for consecutive 5 days (Rvb = 8.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889573Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as body weight loss at 20 mg/kg, po administered once daily for consecutive 5 days in presence of cisplatin relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889593Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in heart weight at 20 to 40 mg/kg, sc administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889595Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in kidney weight at 20 to 40 mg/kg, sc administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889568Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in body weight at 20 to 40 mg/kg, sc administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1503775Antichlamydial activity against Chlamydia pneumoniae K7 infected in HL cells assessed as chlamydial inhibition at 50 uM after 70 hrs by fluorescent microscopic analysis2017Journal of natural products, 10-27, Volume: 80, Issue:10
Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy.
AID1889565Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse bearing assessed as change in cleaved caspase-3 level in tumor at 20 mg/kg, po administered once daily for consecutive 5 days by immunostaining analysis2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889577Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 40 mg/kg, sc for consecutive 5 days (Rvb = 10.00 +/-2.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889563Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, po administered once daily for consecutive 5 days in presence of cisplatin relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889597Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in lung weight at 20 to 40 mg/kg, ip administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1503776Antichlamydial activity against Chlamydia pneumoniae K7 infected in HL cells after 70 hrs by fluorescent microscopic analysis2017Journal of natural products, 10-27, Volume: 80, Issue:10
Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy.
AID1889560Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, ip administered once daily for consecutive 5 days relative to control (Rvb = 71.1%)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889576Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 20 mg/kg, sc for consecutive 5 days (Rvb = 10.00 +/-2.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889587Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in lung weight at 20 to 40 mg/kg, po administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889586Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in heart weight at 20 to 40 mg/kg, po administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889585Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 40 mg/kg, ip for consecutive 5 days (Rvb = 0.91+/-0.01)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889572Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as splenomegaly at 20 mg/kg, ip administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889581Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 40 mg/kg, po for consecutive 5 days (Rvb = 0.90 +/-0.04)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1503774Cytotoxicity against human HL cells assessed as cell viability at 50 uM after 72 hrs by resazurin dye based fluorescence assay relative to control2017Journal of natural products, 10-27, Volume: 80, Issue:10
Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy.
AID1889567Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in body weight at 20 to 40 mg/kg, ip administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889584Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 20 mg/kg, ip for consecutive 5 days (Rvb = 0.91+/-0.01)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889570Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as splenomegaly at 40 mg/kg, ip administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889598Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in kidney weight at 20 to 40 mg/kg, ip administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889583Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 40 mg/kg, sc for consecutive 5 days (Rvb = 0.60 +/-0.01)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889571Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as splenomegaly at 40 mg/kg, sc administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889594Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in lung weight at 20 to 40 mg/kg, sc administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889557Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 40 mg/kg, po administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889569Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as splenomegaly at 40 mg/kg, po administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889561Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 40 mg/kg, ip administered once daily for consecutive 5 days relative to control (Rvb = 71.1%)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889596Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in heart weight at 20 to 40 mg/kg, ip administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889589Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse bearing assessed as change in cleaved caspase-3 level in tumor at 20 mg/kg, po administered once daily for consecutive 5 days in presence of cisplatin by immunostaining analysis2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889592Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as reduction in spleen weight at 20 mg/kg, ip administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889579Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 40 mg/kg, ip for consecutive 5 days (Rvb = 8.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889582Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 20 mg/kg, sc for consecutive 5 days (Rvb = 0.60 +/-0.01)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889556Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, po administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (9.09)18.7374
1990's0 (0.00)18.2507
2000's5 (22.73)29.6817
2010's7 (31.82)24.3611
2020's8 (36.36)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.24 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index4.64 (4.65)
Search Engine Demand Index53.49 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gossypol
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.		2.1510
methyl methanesulfonate
[no description available]		7.110methanesulfonate esteralkylating agent;
apoptosis inducer;
carcinogenic agent;
genotoxin;
mutagen
nalidixic acid
[no description available]		2.15101,8-naphthyridine derivative;
monocarboxylic acid;
quinolone antibiotic		antibacterial drug;
antimicrobial agent;
DNA synthesis inhibitor
ofloxacin
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.. 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.. ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.		2.15103-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		2.1510antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
2-naphthol
2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.		1.9210naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
jervine
jervine: teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structure		2.1510piperidines
indirubin
[no description available]		2.1510
osthol
osthol: from Cnidium monnieri and Angelica pubescens (both Apiaceae); structure given in first source		2.1510botanical anti-fungal agent;
coumarins		metabolite
oleanolic acid
[no description available]		2.1510hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
hesperidin
Hesperidin: A flavanone glycoside found in CITRUS fruit peels.. hesperidin : A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.		2.15103'-hydroxyflavanones;
4'-methoxyflavanones;
dihydroxyflavanone;
disaccharide derivative;
flavanone glycoside;
monomethoxyflavanone;
rutinoside		mutagen
etoposide
[no description available]		2.3110beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
baccatin iii
[no description available]		2.1510acetate ester;
benzoate ester;
tetracyclic diterpenoid		plant metabolite
epicatechin
(-)-epicatechin : A catechin with (2R,3R)-configuration.		2.1510catechin;
polyphenol		antioxidant
honokiol
[no description available]		2.1510biphenyls
eriocitrin
eriocitrin: structure in first source. eriocitrin : A disaccharide derivative that consists of eriodictyol substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.		2.15103'-hydroxyflavanones;
4'-hydroxyflavanones;
disaccharide derivative;
flavanone glycoside;
rutinoside;
trihydroxyflavanone		antioxidant
lupinine
lupinine: RN given refers to parent cpd(1R-trans)-isomer; structure		2.1510quinolizidine alkaloid
podocarpic acid
podocarpic acid: structure. podocarpic acid : An abietane diterpenoid lacking the isopropyl substituent with an aromatic C-ring and a hydroxy group at the 12-position.		2.1510abietane diterpenoid
episesamin
1-asarinine: structure; might this actually be asarinin?(sb)		2.1510
tryptoline
tryptoline: neurotoxic factor that may be involved in development of Parkinson's disease; enzymatic prep from human brain converts tryptamine to tryptoline; RN given refers to parent cpd; structure		2.1510beta-carbolines
deguelin
deguelin: a natural product from Mundulea sericea; RN refers to (7aS-cis)-isomer; structure given in first source. deguelin : A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.		2.1510aromatic ether;
diether;
organic heteropentacyclic compound;
rotenones		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
mitochondrial NADH:ubiquinone reductase inhibitor;
plant metabolite
t-cadinol
T-cadinol: extract of scented myrrh; RN given refers to (1S-(1alpha,4alpha,4aalpha,8abeta)-isomer; RN for cpd without isomeric designation not avail 3/92; structure given in first source. tau-cadinol : A cadinane sesquiterpenoid that is cadin-4-ene carrying a hydroxy substituent at position 10.		2.110cadinane sesquiterpenoid;
carbobicyclic compound;
octahydronaphthalenes;
tertiary alcohol		plant metabolite;
volatile oil component
sclareol
sclareol: structure given in first source. sclareol : A labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea.		2.8730labdane diterpenoidantifungal agent;
antimicrobial agent;
apoptosis inducer;
fragrance;
plant metabolite
leucodin
leucodin: structure in first source		2.1510sesquiterpene lactone
graveoline
graveoline: structure in first source		2.1510quinolines
taxifolin
(+)-taxifolin : A taxifolin that has (2R,3R)-configuration.		2.1510taxifolinmetabolite
digitoxin
Digitoxin: A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). digitoxin : A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.		2.1510cardenolide glycosideEC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.110
dihydroergocristine monomesylate
dihydroergocristine mesylate : The methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia.		2.1510methanesulfonate saltalpha-adrenergic antagonist;
geroprotector;
vasodilator agent
mycophenolic acid
Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.		2.15102-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic
aphidicolin
Aphidicolin: An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.. aphidicolin : A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.		2.1510tetracyclic diterpenoidantimicrobial agent;
antimitotic;
antineoplastic agent;
antiviral drug;
apoptosis inducer;
Aspergillus metabolite;
DNA synthesis inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
fungal metabolite
sesquiterpenes
[no description available]		2.110
vasicine
vasicine: RN given refers to (R)-isomer		2.1510
caryophyllene oxide
caryophyllene oxide: has butyrylcholinesterase inhibitory activity; structure in first source. epoxide : Any cyclic ether in which the oxygen atom forms part of a 3-membered ring.		2.1510epoxidemetabolite
5,6-dehydrokawain
5,6-dehydrokawain: from Alpinia speciosa rhizoma; RN given for cpd without isomeric designation; structure given in first source		2.15102-pyranones;
aromatic ether
prostaglandin b1
prostaglandin Bx: phospholipase A2 inhibitor; polymeric derivative of diketo-PGB1; mean MW 2,200. prostaglandin B1 : A member of the class of prostaglandins B that is prosta-8(12),13-dien-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 13E,15S-stereoisomer).		2.1510prostaglandins Bhuman metabolite
apigetrin
apigetrin: structure given in first source. apigenin 7-O-beta-D-glucoside : A glycosyloxyflavone that is apigenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.		2.1510beta-D-glucoside;
dihydroxyflavone;
glycosyloxyflavone;
monosaccharide derivative		antibacterial agent;
metabolite;
non-steroidal anti-inflammatory drug
quercetin 3-o-glucopyranoside
quercetin 3-O-glucopyranoside: structure in first source. quercetin 3-O-beta-D-glucopyranoside : A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells		2.1510beta-D-glucoside;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone		antineoplastic agent;
antioxidant;
antipruritic drug;
bone density conservation agent;
geroprotector;
histamine antagonist;
osteogenesis regulator;
plant metabolite
chartreusin
chartreusin: structure		2.1510benzochromenone;
glycoside
chrysin
chrysin : A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.		2.15107-hydroxyflavonol;
dihydroxyflavone		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite
coumestrol
Coumestrol: A daidzein derivative occurring naturally in forage crops which has some estrogenic activity.. coumestrol : A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.		2.1510coumestans;
delta-lactone;
polyphenol		anti-inflammatory agent;
antioxidant;
plant metabolite
caffeic acid phenethyl ester
phenethyl caffeate : An alkyl caffeate ester in which 2-phenylethyl is the alkyl component.		2.1510alkyl caffeate esteranti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
antioxidant;
antiviral agent;
immunomodulator;
metabolite;
neuroprotective agent
7-hydroxyflavone
7-hydroxyflavone : A hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group.		2.1510hydroxyflavonoid
natamycin
[no description available]		2.1510antibiotic antifungal drug;
dicarboxylic acid monoester;
epoxide;
macrolide antibiotic;
monosaccharide derivative;
polyene antibiotic		antifungal agrochemical;
antimicrobial food preservative;
apoptosis inducer;
bacterial metabolite;
ophthalmology drug
veratrine
Veratrine: A voltage-gated sodium channel activator.		2.1510alkaloid
monorden
monorden: inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II		2.1510cyclic ketone;
enone;
epoxide;
macrolide antibiotic;
monochlorobenzenes;
phenols		antifungal agent;
metabolite;
tyrosine kinase inhibitor
labdane
labdane: from Croton joufra; structure in first source		2.2510diterpene;
terpenoid fundamental parent
coronarin e
coronarin E: structure in first source		7.0110
copalic acid
copalic acid: a trypanocidal agent isolated from Aristolochia cymbifera; structure in first source		2.0610diterpenoid
cinobufagin
cinobufagin: isolated from Chinese medicinal preparation ch'an su; derived from toad venom		2.1510steroid lactone
ambrein
ambrein: a degraded triterpene; ambrein, cholesterol and benzoic acid are major components of ambergris; from intestinal secretion of sperm blue whale (Pyseter carodon). ambrein : A triterpenoid alcohol that is a constituent of ambergris, an intestinal secretion of the sperm whale Physeter catodon.		6.9210tertiary alcohol;
triterpenoid		hypoglycemic agent;
mammalian metabolite
agelasine d
agelasine D: compound with antibacterial and cytotoxic activities from a marine sponge (Agelas sp.); structure in first source		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Malignant Melanoma
[description not available]		02.4110
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		07.4110
Aggressive Periodontitis
Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.		02.2510
Blood Pressure, High
[description not available]		02.6620
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.		02.6620
Cancer of Colon
[description not available]		02.5220
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.3110
Condition, Preneoplastic
[description not available]		02.3110
Chromosome-Defective Micronuclei
[description not available]		02.3110
Colonic Neoplasms
Tumors or cancer of the COLON.		02.5220
Precancerous Conditions
Pathological conditions that tend eventually to become malignant.		02.3110
Adenocarcinoma, Basal Cell
[description not available]		02.0510
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		02.0510
Pericementitis
[description not available]		02.0610
Periodontitis
Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)		02.0610
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