Page last updated: 2024-12-10

manool

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

manool: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

manool : A labdane diterpenoid in which the labdane skeleton has double bonds at positions 8(17) and 14 and carries an R-hydroxy group at position 13. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID3034394
CHEMBL ID4162501
CHEBI ID76945
SCHEMBL ID12658773
MeSH IDM0462748

Synonyms (30)

Synonym
nsc165961
manool
nsc-165961
(3r)-5-[(1s,4as,8as)-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]-3-methylpent-1-en-3-ol
at5pj0pv00 ,
(+)-manool
(3r)-5-[(1s,4as,8as)-5,5,8a-trimethyl-2-methylene-decalin-1-yl]-3-methyl-pent-1-en-3-ol
labda-8 (20),14-dien-13-ol, (13r)-
1-naphthalenepropanol, .alpha.-ethenyldecahydro-.alpha.,5,5,8a-tetramethyl-2-methylene-, (4as)-
labda-8(17),14-dien-13(r)-ol
(5s,9s,10s,13r)-labda-8(17),14-dien-13-ol
CHEBI:76945
(13r)-manool
(13r)-labda-8(27),14-dien-13-ol
(13r)-labda-8(20),14-dien-13-ol
(3r)-3-methyl-5-[(1s,4as,8as)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl]pent-1-en-3-ol
CCG-208417
(3r)-3-methyl-5-[(1r,4ar,8ar)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]pent-1-en-3-ol
SCHEMBL12658773
1-naphthalenepropanol, .alpha.-ethenyldecahydro-.alpha.,5,5,8a-tetramethyl-2-methylene-, (.alpha.r,1s,4as,8as)-
SR-05000002258-2
sr-05000002258
(r)-3-methyl-5-((1s,4as,8as)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl)pent-1-en-3-ol
Q15726184
(.alpha.r,1s,4as,8as)-.alpha.-ethenyldecahydro-.alpha.,5,5,8a-tetramethyl-2-methylene-1-naphthalenepropanol
MS-24149
CHEMBL4162501
CS-0132370
HY-N1039A
(3r)-5-[(1s,4as,8as)-5,5,8a-trimethyl-2-methylidene-decahydronaphthalen-1-yl]-3-methylpent-1-en-3-ol

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" A gradual increase in manool doses did not cause a proportional reduction of preneoplastic lesions, thus demonstrating the absence of a dose-response relationship."( Manool, a diterpene from Salvia officinalis, exerts preventive effects on chromosomal damage and preneoplastic lesions.
Esperandim, TR; Fernandes, G; Furtado, RA; Nicolella, HD; Ozelin, SD; Ribeiro, AB; Rinaldi-Neto, F; Senedese, JM; Tavares, DC; Veneziani, RCS, 2021
)
2.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
labdane diterpenoidAny diterpenoid with a labdane skeleton.
tertiary alcoholA tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (46)

Assay IDTitleYearJournalArticle
AID1889591Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as reduction in spleen weight at 20 mg/kg, sc administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889566Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in body weight at 20 to 40 mg/kg, po administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889564Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in number of mitotic figures at 20 mg/kg, po administered once daily for consecutive 5 days in presence of cisplatin by H and E staining microscopic analysis2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889574Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 20 mg/kg, po for consecutive 5 days (Rvb = 6.00 +/-1.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889562Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in mitotic figures at 40 mg/kg, ip administered once daily for consecutive 5 days by H and E staining microscopic analysis2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889590Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as reduction in spleen weight at 20 mg/kg, po administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889575Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 40 mg/kg, po for consecutive 5 days (Rvb = 6.00 +/-1.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889559Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 40 mg/kg, sc administered once daily for consecutive 5 days relative to control (Rvb = 50.7%)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889588Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in kidney weight at 20 to 40 mg/kg, po administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889580Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 20 mg/kg, po for consecutive 5 days (Rvb = 0.90 +/-0.04)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889558Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, sc administered once daily for consecutive 5 days relative to control (Rvb = 50.7%)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889578Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 20 mg/kg, ip for consecutive 5 days (Rvb = 8.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889573Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as body weight loss at 20 mg/kg, po administered once daily for consecutive 5 days in presence of cisplatin relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889593Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in heart weight at 20 to 40 mg/kg, sc administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889595Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in kidney weight at 20 to 40 mg/kg, sc administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889568Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in body weight at 20 to 40 mg/kg, sc administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1503775Antichlamydial activity against Chlamydia pneumoniae K7 infected in HL cells assessed as chlamydial inhibition at 50 uM after 70 hrs by fluorescent microscopic analysis2017Journal of natural products, 10-27, Volume: 80, Issue:10
Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy.
AID1889565Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse bearing assessed as change in cleaved caspase-3 level in tumor at 20 mg/kg, po administered once daily for consecutive 5 days by immunostaining analysis2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889577Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 40 mg/kg, sc for consecutive 5 days (Rvb = 10.00 +/-2.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889563Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, po administered once daily for consecutive 5 days in presence of cisplatin relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889597Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in lung weight at 20 to 40 mg/kg, ip administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1503776Antichlamydial activity against Chlamydia pneumoniae K7 infected in HL cells after 70 hrs by fluorescent microscopic analysis2017Journal of natural products, 10-27, Volume: 80, Issue:10
Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy.
AID1889560Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, ip administered once daily for consecutive 5 days relative to control (Rvb = 71.1%)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889576Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 20 mg/kg, sc for consecutive 5 days (Rvb = 10.00 +/-2.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889587Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in lung weight at 20 to 40 mg/kg, po administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889586Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in heart weight at 20 to 40 mg/kg, po administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889585Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 40 mg/kg, ip for consecutive 5 days (Rvb = 0.91+/-0.01)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889572Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as splenomegaly at 20 mg/kg, ip administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889581Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 40 mg/kg, po for consecutive 5 days (Rvb = 0.90 +/-0.04)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1503774Cytotoxicity against human HL cells assessed as cell viability at 50 uM after 72 hrs by resazurin dye based fluorescence assay relative to control2017Journal of natural products, 10-27, Volume: 80, Issue:10
Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy.
AID1889567Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in body weight at 20 to 40 mg/kg, ip administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889584Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 20 mg/kg, ip for consecutive 5 days (Rvb = 0.91+/-0.01)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889570Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as splenomegaly at 40 mg/kg, ip administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889598Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in kidney weight at 20 to 40 mg/kg, ip administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889583Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 40 mg/kg, sc for consecutive 5 days (Rvb = 0.60 +/-0.01)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889571Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as splenomegaly at 40 mg/kg, sc administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889594Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in lung weight at 20 to 40 mg/kg, sc administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889557Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 40 mg/kg, po administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889569Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as splenomegaly at 40 mg/kg, po administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889561Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 40 mg/kg, ip administered once daily for consecutive 5 days relative to control (Rvb = 71.1%)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889596Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in heart weight at 20 to 40 mg/kg, ip administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889589Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse bearing assessed as change in cleaved caspase-3 level in tumor at 20 mg/kg, po administered once daily for consecutive 5 days in presence of cisplatin by immunostaining analysis2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889592Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as reduction in spleen weight at 20 mg/kg, ip administered once daily for consecutive 5 days2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889579Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as micronucleated polychromatic erythrocytes frequency in bone marrow cells at 40 mg/kg, ip for consecutive 5 days (Rvb = 8.00)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889582Genotoxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as ratio of polychromatic erythrocytes to total erythrocytes in bone marrow cells at 20 mg/kg, sc for consecutive 5 days (Rvb = 0.60 +/-0.01)2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
AID1889556Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, po administered once daily for consecutive 5 days relative to control2022Journal of natural products, 02-25, Volume: 85, Issue:2
Antitumor Effect of Manool in a Murine Melanoma Model.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (9.09)18.7374
1990's0 (0.00)18.2507
2000's5 (22.73)29.6817
2010's7 (31.82)24.3611
2020's8 (36.36)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.24 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index4.64 (4.65)
Search Engine Demand Index53.49 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]