manool and sclareol

manool has been researched along with sclareol* in 3 studies

*sclareol: structure given in first source [MeSH]

*sclareol: structure given in first source [MeSH]

Other Studies

3 other study(ies) available for manool and sclareol

ArticleYear
Activity difference of three labdane diterpenoids on human constitutive androstane receptor.
    Bioscience, biotechnology, and biochemistry, 2023, Oct-25, Volume: 87, Issue:11

    The constitutive androstane receptor (CAR) regulates enzyme transcription related to drug metabolism; therefore, natural compound clarification in food that interacts with CAR is significant for drug development. We revealed that 13-epimanool, which is a compound found in the common sage, is bound to hCAR based on differential scanning fluorometry (DSF) measurements using recombinant hCAR protein. Similar labdane diterpenoids were examined, which revealed that manool and sclareol, which were both natural compounds contained in herbs, are bound to hCAR. They exhibited different effects for CAR activity in the luciferase assay despite the structural similarity. Manool was a partial agonist, 13-epimanool was a weak partial agonist, and sclareol was an antagonist. The activity of hCAR may be regulated by slight differences in the bound compound.

    Topics: Constitutive Androstane Receptor; Diterpenes; Humans; Receptors, Cytoplasmic and Nuclear

2023
Antibacterial and ATP Synthesis Modulating Compounds from
    Journal of natural products, 2020, 04-24, Volume: 83, Issue:4

    A surface extract of the aerial parts of

    Topics: Abietanes; Adenosine Triphosphate; Anti-Bacterial Agents; Diterpenes; Enterococcus faecalis; Flavonoids; Humans; Lactones; Molecular Structure; Plant Components, Aerial; Salvia

2020
Antimicrobial evaluation of diterpenes from Copaifera langsdorffii oleoresin against periodontal anaerobic bacteria.
    Molecules (Basel, Switzerland), 2011, Nov-18, Volume: 16, Issue:11

    The antimicrobial activity of four labdane-type diterpenes isolated from the oleoresin of Copaifera langsdorffii as well as of two commercially available diterpenes (sclareol and manool) was investigated against a representative panel of microorganisms responsible for periodontitis. Among all the evaluated compounds, (-)-copalic acid (CA) was the most active, displaying a very promising MIC value (3.1 µg mL-1; 10.2 µM) against the key pathogen (Porphyromonas gingivalis) involved in this infectious disease. Moreover, CA did not exhibit cytotoxicity when tested in human fibroblasts. Time-kill curve assays performed with CA against P. gingivalis revealed that this compound only inhibited the growth of the inoculums in the first 12 h (bacteriostatic effect). However, its bactericidal effect was clearly noted thereafter (between 12 and 24 h). It was also possible to verify an additive effect when CA and chlorhexidine dihydrochloride (CHD, positive control) were associated at their MBC values. The time curve profile resulting from this combination showed that this association needed only six hours for the bactericidal effect to be noted. In summary, CA has shown to be an important metabolite for the control of periodontal diseases. Moreover, the use of standardized extracts based on copaiba oleoresin with high CA contents can be an important strategy in the development of novel oral care products.

    Topics: Anti-Infective Agents; Diterpenes; Fabaceae; Humans; Microbial Sensitivity Tests; Molecular Structure; Periodontitis; Plant Extracts; Porphyromonas gingivalis

2011