Compounds > propylenethiourea
Page last updated: 2024-11-09

propylenethiourea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID2723785
CHEMBL ID11938
SCHEMBL ID90036
MeSH IDM0107615

Synonyms (69)

Synonym
einecs 218-152-3
1,4,5,6-tetrahydro-2-pyrimidinethiol
propylenethiourea
ai3-61107
3,4,5,6-tetrahydropyrimidine-2-thiol
2-mercapto-3,4,5,6-tetrahydropyrimidine
thiourea, n,n'-1,3-propanediyl-
2-mercapto-1,4,5,6-tetrahydropyrimidine
3,4,5,6-tetrahydro-2-pyrimidinethiol
nsc 21316
3,5,6-tetrahydro-2-pyrimidinethiol
2(1h)-pyrimidinethione, tetrahydro-
thiourea,n'-1,3-propanediyl-
1,3-propylenethiourea
1,5,6-tetrahydro-2-pyrimidinethiol
tetrahydropyrimidine-2-thione
2055-46-1
hexahydropyrimidine-2-thione
2-mercapto-3,5,6-tetrahydropyrimidine
cyclic propylene thiourea
2-mercaptotetrahydropyrimidine
2-mercapto-1,5,6-tetrahydropyrimidine
nsc21316
wln: t6mymtj bus
tetrahydro-2(1h)-pyrimidinethione
n,n'-trimethylenethiourea
nsc-21316
3,4,5,6-tetrahydro-2-pyrimidinethiol, >=99%
tetrahydropyrimidine-2(1h)-thione
STK386301
1,4,5,6-tetrahydropyrimidine-2-thiol
AKOS000267507
CHEMBL11938
STK802300
1,3-diazinane-2-thione
AKOS000120992
unii-v3btd5l7bn
v3btd5l7bn ,
A814694
2-(1h)-tetrahydropyrimidinethione
FT-0676434
PS-4155
3,4,5,6-tetrahydro-1h-pyrimidine-2-thione
SCHEMBL90036
BBL027546
tetrahydro-2-pyrimidinethione
1,4,5,6-tetrahydro-2- pyrimidinethiol
3,4,5,6-tetrahydro-2-pyrimidine-thiol
1,4,5,6-tetrahydropyrimidin-2-thione
3,4,5,6-tetrahydro(1h)pyrimidine-2-thione
DTXSID3062156
1219802-05-7
1,3-propylene-d6 thiourea
perhydropyrimidine-2-thione
3,4,5,6-tetrahydro-2(1h)-pyrimidinethione
1,4,5,6-tetrahydro-pyrimidine-2-thiol
2(1h)-pyrimidinethione,tetrahydro-
F0001-0729
3,4,5,6-teterahydro-2-pyrimidinethiol
mfcd00060526
J-013419
93B ,
EN300-18688
AMY7063
D97545
trimethylenthioharnstoff
CS-0073474
3,4,5,6-tetrahydro-2-mercaptopyrimidine
SY062631

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"For the last 30 years the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) has carried out toxicological evaluations and safety assessments of dithiocarbamate pesticides, continuously adjusting previous appraisals in the light of new data and advances in the understanding of the principles and mechanisms of toxic action of these compounds."( International safety assessment of pesticides: dithiocarbamate pesticides, ETU, and PTU--a review and update.
Almeida, WF; Burin, GJ; Jaeger, RB; Puga, FR; Rahde, AF; Reyes, FG; Schvartsman, S; Vettorazzi, G, )		0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID71664Cell growth of friend erythroleukemia cells measured as percentage of control on day 6 at a concentration of 2 mM1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Cyclic urea and thiourea derivatives as inducers of murine erythroleukemia differentiation.
AID71672Percent of untreated control cell growth evaluated in friend leukemia cells on day 3 at a concentration of 2 mM1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Cyclic urea and thiourea derivatives as inducers of murine erythroleukemia differentiation.
AID71653The degree of erythroid maturation was measured by assessing the proportion of benzidine-positive cells at a concentration of 2 mM1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Cyclic urea and thiourea derivatives as inducers of murine erythroleukemia differentiation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (33.33)18.7374
1990's0 (0.00)18.2507
2000's4 (33.33)29.6817
2010's4 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.38 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index20.59 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.14%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		2.0110halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
trimethylenediamine
trimethylenediamine: RN given refers to parent cpd; structure. trimethylenediamine : An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.		2.1710alkane-alpha,omega-diaminehuman metabolite;
mouse metabolite;
reagent
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		1.9610sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
acephate
acephate : A phosphoramide that is methamidophos in which one of the hydrogens is replaced by an acetyl group.		7.0310mixed diacylamine;
organic thiophosphate;
organothiophosphate insecticide;
phosphoramide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
dimethoate
Dimethoate: An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.. dimethoate : A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.		7.0310monocarboxylic acid amide;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
disulfiram
[no description available]		2.0110organic disulfide;
organosulfur acaricide		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 3.1.1.1 (carboxylesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
ferroptosis inducer;
fungicide;
NF-kappaB inhibitor
methamidophos
methamidophos: structure. methamidophos : An organic thiophosphate resulting from the N-deacylation of the proinsecticide acephate.		7.0310organic thiophosphate;
organothiophosphate insecticide;
phosphoramide		acaricide;
agrochemical;
avicide
methyl methanesulfonate
[no description available]		1.9610methanesulfonate esteralkylating agent;
apoptosis inducer;
carcinogenic agent;
genotoxin;
mutagen
zinc chloride
zinc chloride: RN given refers to parent cpd. zinc dichloride : A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.		2.0110inorganic chloride;
zinc molecular entity		astringent;
disinfectant;
EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor;
Lewis acid
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		1.9610mitomycinalkylating agent;
antineoplastic agent
carbon disulfide
Carbon Disulfide: A colorless, flammable, poisonous liquid, CS2. It is used as a solvent, and is a counterirritant and has local anesthetic properties but is not used as such. It is highly toxic with pronounced CNS, hematologic, and dermatologic effects.		2.0110one-carbon compound;
organosulfur compound
1,3-dimethyl-2-imidazolidinone
1,3-dimethyl-2-imidazolidinone: structure in first source		1.9610imidazolidinone
ethylene urea
ethylene urea: used in manufacture of polymers, finishing agents for textiles & leather, in formulation of plasticizers, lacquers & adhesives; structure. imidazolidinone : An imidazolidine containing one or more oxo groups.		1.9610imidazolidinone;
ureas
ditiocarb
Ditiocarb: A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.. diethyldithiocarbamic acid : A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.		2.0110dithiocarbamic acidschelator;
copper chelator
1,1,3,3-tetramethylurea
1,1,3,3-tetramethylurea: structure. 1,1,3,3-tetramethylurea : A member of the class of ureas that is urea substituted by methyl groups at positions 1, 1, 3 and 3 respectively. Metabolite observed in cancer metabolism.		1.9610ureashuman metabolite
dimethoxon
dimethoxon: pesticide		2.0310organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
tetramethylthiourea
[no description available]		1.9610thioureas
tetrahydropyrimidinone
tetrahydropyrimidinone: structure in first source		1.9610
n,n'-dimethylpropyleneurea
N,N'-dimethylpropyleneurea: structure in first source		1.9610
ethylenethiourea
Ethylenethiourea: A degradation product of ethylenebis(dithiocarbamate) fungicides. It has been found to be carcinogenic and to cause THYROID hyperplasia.		3.2760imidazolidines
thiourea
Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.		3.8110one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
zineb
Zineb: An agricultural fungicide of the dithiocarbamate class. It has relatively low toxicity and there is little evidence of human injury from exposure.. zineb : A polymeric complex of zinc with the ethylene bis(dithiocarbamate) anionic ligand. Formerly used as an agricultural fungicide for the control of downy mildews and rusts, its use is no longer permitted in the US or the EU.		3.150dithiocarbamate salt;
macromolecule;
zinc coordination entity		antifungal agrochemical
propineb
propineb: structure. propineb : A polymeric complex of zinc with the propylene 1,2-bis(dithiocarbamate) anionic ligand. A fungicide, it is used to control a wide range of fungal diseases, including downy mildew, brown rot, black rot, red fire, leaf spot, and blight in crops such as grapes, tomatoes, potatoes, berries, citrus, rice and tea.		3.150dithiocarbamate salt;
macromolecule;
zinc coordination entity		antifungal agrochemical
ConditionIndicatedRelationship StrengthStudiesTrials
Di Guglielmo Disease
[description not available]		01.9610
Experimental Leukemia
[description not available]		01.9610
Leukemia, Erythroblastic, Acute
A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.		01.9610
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.4720
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.6730
Complications, Pregnancy
[description not available]		01.9610