Compounds > n,n'-dimethylpropyleneurea
Page last updated: 2024-12-07

n,n'-dimethylpropyleneurea

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Description

n,n'-dimethylpropyleneurea (DMPU) is a colorless, odorless, hygroscopic liquid that is used as a solvent and a reagent in organic synthesis. It is a highly polar aprotic solvent, which means that it does not have a hydrogen atom attached to an electronegative atom. This property makes DMPU a good solvent for many organic reactions, as it does not interfere with the reaction mechanism. DMPU is also a good reagent for the synthesis of many organic compounds, such as amides, esters, and ethers. DMPU is a relatively inexpensive and readily available solvent, which makes it a popular choice for organic chemists. Its importance lies in its ability to dissolve a wide range of organic compounds, including polar and non-polar compounds. It is also a good solvent for many inorganic compounds. DMPU is studied for its ability to improve the solubility of organic compounds and its ability to promote certain organic reactions. DMPU is also used in the synthesis of pharmaceuticals, pesticides, and other chemicals. It is also used as a solvent in the production of polymers and plastics.'

N,N'-dimethylpropyleneurea: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID81646
CHEMBL ID12284
SCHEMBL ID82580
MeSH IDM0380300

Synonyms (100)

Synonym
tetrahydro-1,3-dimethyl-2(1h)pyrimidine
brn 0110562
n,n'-dimethyltrimethyleneurea
einecs 230-625-6
ccris 4322
tetrahydro-1,3-dimethyl-1h-pyrimidin-2-one
dimethylpropyleneurea
ec 230-625-6
dmpu
7226-23-5
2(1h)-pyrimidinone, tetrahydro-1,3-dimethyl-
2-pyrimidone,tetrahydro,1,3-dimethyl
1,3-dimethyltetrahydropyrimidin-2(1h)-one
inchi=1/c6h12n2o/c1-7-4-3-5-8(2)6(7)9/h3-5h2,1-2h
1,3-dimethyl-3,4,5,6-tetrahydro-2(1h)-pyrimidinone, 98%
1,3-dimethyl-3,4,5,6-tetrahydro-2(1h)-pyrimidinone, absolute, over molecular sieve (h2o <=0.03%), >=99.0% (gc)
1,3-dimethyl-3,4,5,6-tetrahydro-2(1h)-pyrimidinone
CHEMBL12284
AKOS005145503
D2014
n,n'-dimethylpropyleneurea
1,3-dimethyl-1,3-diazinan-2-one
A837469
EN300-82368
1,3-dimethyl-3,4,5,6-tetrahydro-2[1h]-pyrimidinone
n,n'-dimethylpropylene urea
FT-0606689
SCHEMBL82580
J-503925
1,3-dimethyl-2-oxohexahydropyrimidine
n,n'-dimethylproyleneurea
1,3-dimethyl-3,4,5,6-tetrahydro-2 [1h]-pyrimidinone
1,3-dimethyl-3,4,5,6-tetrahydropyrimidinone
1,3-dimethyl-3,4,5,6tetrahydro-2(1h)-pyrimidinone
1,3-dimethyl-tetrahydro-pyrimidin-2-one
1,3-dimethyltetrahydro-2(1h)-pyrimidone
1,3-dimethyl-3,4,5,6-tetrahydro-2(1h)-pyrimidone
1,3-dimethyl-3,4,5,6-tetrahydro-2 (1h)pyrimidinone
1,3-dimethyl-3,4,5,6-tetrahydro-(1h)-pyrimidin-2-one
1,3-di-methyl-3,4,5,6-tetrahydro-2(1h)-pyrimidinone
1,3-dimethyltetrahydro-2(1h)pyrimidinon
1,3-dimethyl-3,4,5,6-tetrahydro-2(1h)-pyrirnidinone
1,3-dimethyl-2,4,5,6-tetrahydro-2(1h)-pyrimidinone
1,3-dimethyl-tetrahydro-2-1h-pyrimidinone
1,3-dimethyltetrahydro-2-(1h)-pyrimidinone
1,3-di- methyl-3,4,5,6-tetrahydro-2(1h)-pyrimidinone
n,n'-dimethyl -1,4,5,6-tetrahydro-2-pyrimidone
1,3-dimethyl-3,4,5,6-tetrahydro-2-(1h)-pyrimidinone
1,3-dimethyl-3,4,5,6-tetrahydro 2(1h) pyrimidone
1,3-dimethyl-3,4,5,6-tetrahydro-2(1h)-pyrimidinon
1,3-dimethyl-3,4,5,6-tetrahydro-2(1h)pyrimidinone
1,3-dimethyl -3,4,5,6-tetrahydro-2(1h)-pyrimidinone
1,3-dimethyl-3,4,5, 6-tetrahydro -2(1h)-pyrimidinone
dimethyl-3,4,5,6-tetrahydro-2(1h)-pyrimidinone
n,n'-dimethyl-1,4,5,6-tetrahydro-2-pyrimidone
1,3-dimethyl-3,4,5,6-tetrahydro-2 (1h)-pyrimidone
1,3-dimethyl-3,4,5,6-tetrahydro-2(1h)- pyrimidinone
1,3-dimethyl tetrahydropyrimidin-2(1h)-one
1,3-dimethyl-3,4,5,6-tetrahydro 2 (1h)-pyrimidinone
1,3-dimethyl-3,4,5,6-tetrahydro-2 (1 h)-pyrimidinone
1,3-dimethyl-3,4,5,6-tetrahydro-2(1 h)-pyrimidinone
1,3-dimethyl-3,4,5,6-tetrahydropyrimidin-2-one
dimethylpropyl-eneurea
1,3-dimethyl-3,4,5,6-tetrahydro-2-pyrimidinone
1,3-dimethyl-tetrahydropyrimidin-2-one
1,3-dimethyl-3,4,5,6-tetrahydro2(1h)-pyrimidinone
1,3-dimethyltetrahydro-2-pyrimidinone
1,3-dimethyltetrahydro-2(1h)-pyrimidinone
1,3-dimethyl-3,4,5,6-tetrahydro- -2-(1h)-pyrimidone
1,3-dim-ethyl-3,4,5,6-tetrahydro-2(1h)-pyrimidinone
1,3-dimethyl propylene urea
1,3-dimethyl-3,4,5,6-tetrahydro-2 (1h)-pyrimidinone
1,3-dimethyl-3,4,5,6-tetra-hydro-(1h)-pyrimidin-2-one
n, n'-dimethylpropyleneurea
1,3-dimethyl-tetrahydro -pyrimidin-2-one
1,3-dimethyl-3,4,5,6-tetrahydro-2-(1h)pyrimidone
1,3-dimethyl-3,4,5,6-tetrahydro-2(1h)pyrimdinone
1,3 dimethyl 3,4,5,6-tetrahydro-2-pyrimidone
STR03401
tetrahydro-1,3-dimethyl-2(1h)pyrimidin-2-onee
1,3-dimethyl-tetrahydro-2(1h)-pyrimidone
mfcd00006550
DTXSID3074575 ,
CS-W009128
P17490
F0001-1844
BCP25854
labotest-bb lt00848352 dmpu dimethylpropylene urea dimethyl(1,3-)-3,4,5,6-tetrahydro-2h-pyrimidone 1,3-dimet
Q416637
n,n-dimethyl-propylene-urea
AMY12538
1,3-dimethyl-3,4,5,6-tetrahydro-2(1h)-pyrimidinone (dmpu)
SY002520
1,3-dimethyltetrahydro-2-pyrimidone
n,n'-dimethylpropyleneurea (dmpu)
PB47348
1,3-dimethyl-2-oxohexahydropyrimidine, n,n'-dimethylpropylene urea, dmpu
1,3-dmethyl-3,4,5,6-tetrahydro-2(1h)-pyrimidinone
Z1237078782
HY-Y0100
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID1570847Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay2019ACS medicinal chemistry letters, Oct-10, Volume: 10, Issue:10
A Bioreductive Prodrug of Cucurbitacin B Significantly Inhibits Tumor Growth in the 4T1 Xenograft Mice Model.
AID1570846Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay2019ACS medicinal chemistry letters, Oct-10, Volume: 10, Issue:10
A Bioreductive Prodrug of Cucurbitacin B Significantly Inhibits Tumor Growth in the 4T1 Xenograft Mice Model.
AID71672Percent of untreated control cell growth evaluated in friend leukemia cells on day 3 at a concentration of 2 mM1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Cyclic urea and thiourea derivatives as inducers of murine erythroleukemia differentiation.
AID71653The degree of erythroid maturation was measured by assessing the proportion of benzidine-positive cells at a concentration of 2 mM1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Cyclic urea and thiourea derivatives as inducers of murine erythroleukemia differentiation.
AID71664Cell growth of friend erythroleukemia cells measured as percentage of control on day 6 at a concentration of 2 mM1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Cyclic urea and thiourea derivatives as inducers of murine erythroleukemia differentiation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's0 (0.00)18.2507
2000's4 (40.00)29.6817
2010's5 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.32

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.32 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.32)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		3.2560sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		3.5480isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.2110indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
dimethylformamide
Dimethylformamide: A formamide in which the amino hydrogens are replaced by methyl groups.. N,N-dimethylformamide : A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.		2.4420formamides;
volatile organic compound		geroprotector;
hepatotoxic agent;
polar aprotic solvent
1,3-dimethyl-2-imidazolidinone
1,3-dimethyl-2-imidazolidinone: structure in first source		1.9610imidazolidinone
ethylene urea
ethylene urea: used in manufacture of polymers, finishing agents for textiles & leather, in formulation of plasticizers, lacquers & adhesives; structure. imidazolidinone : An imidazolidine containing one or more oxo groups.		1.9610imidazolidinone;
ureas
1,1,3,3-tetramethylurea
1,1,3,3-tetramethylurea: structure. 1,1,3,3-tetramethylurea : A member of the class of ureas that is urea substituted by methyl groups at positions 1, 1, 3 and 3 respectively. Metabolite observed in cancer metabolism.		2.3920ureashuman metabolite
tetramethylthiourea
[no description available]		1.9610thioureas
lanthanum
[no description available]		710f-block element atom;
lanthanoid atom;
scandium group element atom
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		7.0210cadmium molecular entity;
zinc group element atom
deuterium oxide
Deuterium Oxide: The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.		2.0610deuterated compound;
water		NMR solvent
dimethylacetamide
hallucinogen : Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations and other alterations of mood and thinking.. N,N-dimethylacetamide : A member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism.		2.0610acetamides;
monocarboxylic acid amide		human metabolite
tetrahydropyrimidinone
tetrahydropyrimidinone: structure in first source		2.4120
ethylenethiourea
Ethylenethiourea: A degradation product of ethylenebis(dithiocarbamate) fungicides. It has been found to be carcinogenic and to cause THYROID hyperplasia.		1.9610imidazolidines
propylenethiourea
[no description available]		1.9610
tamoxifen
[no description available]		2.2110stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
cucurbitacin b
[no description available]		2.2110cucurbitacin;
secondary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
lead
Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.		2.0610carbon group element atom;
elemental lead;
metal atom		neurotoxin
bismuth
Bismuth: A metallic element that has the atomic symbol Bi, and atomic number 83. Its principal isotope is Bismuth 209.		710metal atom;
pnictogen
thallium
Thallium: A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.. thallium : A metallic element first identified and named from the brilliant green line in its flame spectrum (from Greek thetaalphalambdalambdaomicronsigma, a green shoot).		7.0110boron group element atom
phosphorus
Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.		2.1710monoatomic phosphorus;
nonmetal atom;
pnictogen		macronutrient
ConditionIndicatedRelationship StrengthStudiesTrials
Di Guglielmo Disease
[description not available]		01.9610
Experimental Leukemia
[description not available]		01.9610
Leukemia, Erythroblastic, Acute
A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.		01.9610