sordarin and Leukemia-P388

sordarin has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for sordarin and Leukemia-P388

Article	Year
BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties. The Journal of antibiotics, 1998, Volume: 51, Issue:12 A new antifungal antibiotic, BE-31405, was isolated from the culture broth of a fungal strain, Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent growth inhibitory activity against pathogenic fungal strains such as Candida albicans, Candida glabrata and Cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as P388 mouse leukemia. The mechanism studies indicated that BE-31405 inhibited the protein synthesis of C. albicans but not of mammalian cells. Topics: Animals; Antibiotics, Antineoplastic; Antifungal Agents; Bridged-Ring Compounds; Candida; Candida albicans; Chemical Phenomena; Chemistry, Physical; Cryptococcus neoformans; Drug Screening Assays, Antitumor; Fermentation; In Vitro Techniques; Indenes; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Microbial Sensitivity Tests; Molecular Structure; Penicillium; Protein Synthesis Inhibitors; Rabbits; Reticulocytes; Tumor Cells, Cultured	1998

Article

Year

BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties.

The Journal of antibiotics, 1998, Volume: 51, Issue:12

A new antifungal antibiotic, BE-31405, was isolated from the culture broth of a fungal strain, Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent growth inhibitory activity against pathogenic fungal strains such as Candida albicans, Candida glabrata and Cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as P388 mouse leukemia. The mechanism studies indicated that BE-31405 inhibited the protein synthesis of C. albicans but not of mammalian cells.

Topics: Animals; Antibiotics, Antineoplastic; Antifungal Agents; Bridged-Ring Compounds; Candida; Candida albicans; Chemical Phenomena; Chemistry, Physical; Cryptococcus neoformans; Drug Screening Assays, Antitumor; Fermentation; In Vitro Techniques; Indenes; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Microbial Sensitivity Tests; Molecular Structure; Penicillium; Protein Synthesis Inhibitors; Rabbits; Reticulocytes; Tumor Cells, Cultured

1998