sordarin has been researched along with Leukemia-P388* in 1 studies
1 other study(ies) available for sordarin and Leukemia-P388
Article | Year |
---|---|
BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties.
A new antifungal antibiotic, BE-31405, was isolated from the culture broth of a fungal strain, Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent growth inhibitory activity against pathogenic fungal strains such as Candida albicans, Candida glabrata and Cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as P388 mouse leukemia. The mechanism studies indicated that BE-31405 inhibited the protein synthesis of C. albicans but not of mammalian cells. Topics: Animals; Antibiotics, Antineoplastic; Antifungal Agents; Bridged-Ring Compounds; Candida; Candida albicans; Chemical Phenomena; Chemistry, Physical; Cryptococcus neoformans; Drug Screening Assays, Antitumor; Fermentation; In Vitro Techniques; Indenes; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Microbial Sensitivity Tests; Molecular Structure; Penicillium; Protein Synthesis Inhibitors; Rabbits; Reticulocytes; Tumor Cells, Cultured | 1998 |