sordarin and Cryptococcosis

sordarin has been researched along with Cryptococcosis* in 1 studies

Other Studies

1 other study(ies) available for sordarin and Cryptococcosis

ArticleYear
In vitro susceptibility of Cryptococcus neoformans serotypes to GM 237354 derivative of the sordarin class.
    Mycoses, 2002, Volume: 45, Issue:8

    In vitro susceptibility to the sordarin derivative GM 237354 and amphotericin B were tested in a total of 190 Cryptococcus neoformans clinical isolates from different geographical areas of Spain and South American countries. Minimal inhibitory concentrations (MICs) were obtained using the NCCLS reference microbroth dilution method and analysed according the serotypes of Cr. neoformans. The MICs for amphotericin B were lower than 1.0 microg ml(-1) (MIC90% 0.5 microg ml(-1) , MIC50% 0.125 microg ml(-1)) but five isolates showed MICs of 2.0 microg ml(-1) to GM 237354 (MIC90% 1.0 microg ml(-1), MIC50% 0.5 microg ml(-1)). Cryptococcus neoformans var. gattii serotype B, was significantly less susceptible than A and AD serotypes (P = 0.047 and P = 0.022, respectively).

    Topics: Amphotericin B; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Humans; Indenes; Microbial Sensitivity Tests; Serotyping

2002