Compounds > proximicin b
Page last updated: 2024-11-13

proximicin b

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Description

proximicin B: antineoplastic agent isolated from Verrucosispora; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID24829331
CHEMBL ID562052
SCHEMBL ID16072063
MeSH IDM0522357

Synonyms (4)

Synonym
CHEMBL562052
proximicin b
SCHEMBL16072063
methyl n-[5-[[5-[2-(4-hydroxyphenyl)ethylcarbamoyl]furan-3-yl]carbamoyl]furan-3-yl]carbamate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID1657464Antibacterial activity against methicillin-resistant Staphylococcus aureus shhsA1 by CLSI based susceptibility test method2020Journal of natural products, 04-24, Volume: 83, Issue:4
Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived
AID425453Cytotoxicity against human AGS cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry letters, Jul-15, Volume: 19, Issue:14
Synthesis and evaluation of a netropsin-proximicin-hybrid library for DNA binding and cytotoxicity.
AID649519Antimicrobial activity against Escherichia coli NCTC 10418 after 24 hrs by MTT assay2012Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6
Efficient synthesis and biological evaluation of proximicins A, B and C.
AID649509Induction of apoptosis in human Jurkat 16 cells assessed as DNA fragments release from apoptotic nuclei after 48 hrs by propidium iodide based flow cytometry analysis2012Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6
Efficient synthesis and biological evaluation of proximicins A, B and C.
AID1657466Antibacterial activity against Micrococcus luteus SCSIO ML01 by CLSI based susceptibility test method2020Journal of natural products, 04-24, Volume: 83, Issue:4
Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived
AID425455Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry letters, Jul-15, Volume: 19, Issue:14
Synthesis and evaluation of a netropsin-proximicin-hybrid library for DNA binding and cytotoxicity.
AID1657468Inhibition of tyrosinase (unknown origin) at 20 uM using L-DOPA as substrate2020Journal of natural products, 04-24, Volume: 83, Issue:4
Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived
AID1657465Antibacterial activity against Bacillus subtilis 1064 by CLSI based susceptibility test method2020Journal of natural products, 04-24, Volume: 83, Issue:4
Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived
AID649517Antimicrobial activity against epidemic methicillin-resistant Staphylococcus aureus 15 after 24 hrs by MTT assay2012Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6
Efficient synthesis and biological evaluation of proximicins A, B and C.
AID1657469Inhibition of electric eel AChE at 20 uM using acetylthiocholine iodide as substrate incubated for 6 mins by Ellman's method2020Journal of natural products, 04-24, Volume: 83, Issue:4
Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived
AID1657473Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay2020Journal of natural products, 04-24, Volume: 83, Issue:4
Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived
AID1601822Antimycobacterial activity against Mycobacterium bovis BCG2019European journal of medicinal chemistry, Mar-01, Volume: 165Marine natural products as potential anti-tubercular agents.
AID1657471Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay2020Journal of natural products, 04-24, Volume: 83, Issue:4
Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived
AID1657463Antibacterial activity against Staphylococcus aureus ATCC 29213 by CLSI based susceptibility test method2020Journal of natural products, 04-24, Volume: 83, Issue:4
Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived
AID649515Antimicrobial activity against epidemic methicillin-resistant Staphylococcus aureus 16 after 24 hrs by MTT assay2012Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6
Efficient synthesis and biological evaluation of proximicins A, B and C.
AID649507Induction of apoptosis in human Jurkat 16 cells assessed as DNA fragments release from apoptotic nuclei at 20 ug/ml after 24 hrs by propidium iodide based flow cytometry analysis2012Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6
Efficient synthesis and biological evaluation of proximicins A, B and C.
AID649518Antimicrobial activity against Enterococcus faecalis NCTC 12697 after 24 hrs by MTT assay2012Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6
Efficient synthesis and biological evaluation of proximicins A, B and C.
AID649516Antimicrobial activity against Staphylococcus aureus SA 1199B over-expressing NorA MDR efflux pump after 24 hrs by MTT assay2012Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6
Efficient synthesis and biological evaluation of proximicins A, B and C.
AID649508Induction of apoptosis in human L1236 cells assessed as DNA fragments release from apoptotic nuclei at 20 ug/ml after 24 hrs by propidium iodide based flow cytometry analysis2012Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6
Efficient synthesis and biological evaluation of proximicins A, B and C.
AID1657472Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by SRB assay2020Journal of natural products, 04-24, Volume: 83, Issue:4
Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived
AID1657467Inhibition of alpha-glucosidase (unknown origin) at 20 uM using pNPG as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins2020Journal of natural products, 04-24, Volume: 83, Issue:4
Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived
AID649514Antimicrobial activity against Staphylococcus aureus ATCC 29523 after 24 hrs by MTT assay2012Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6
Efficient synthesis and biological evaluation of proximicins A, B and C.
AID1657470Cytotoxicity against human SF268 cells assessed as reduction in cell viability after 48 hrs by SRB assay2020Journal of natural products, 04-24, Volume: 83, Issue:4
Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived
AID425454Cytotoxicity against human HepG2 cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry letters, Jul-15, Volume: 19, Issue:14
Synthesis and evaluation of a netropsin-proximicin-hybrid library for DNA binding and cytotoxicity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.27 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (11.11%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		2.2510sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
stallimycin
[no description available]		2.4520
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		3.3110carbohydrazideantitubercular agent;
drug allergen
netropsin
Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.		3.5780
trimethoprim
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.. trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.		2.2510aminopyrimidine;
methoxybenzenes		antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic
gliotoxin
Gliotoxin: A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.. gliotoxin : A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.		3.3110dipeptide;
organic disulfide;
organic heterotetracyclic compound;
pyrazinoindole		antifungal agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
immunosuppressive agent;
mycotoxin;
proteasome inhibitor
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.2510beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
furan
furan : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.		2.4520furans;
mancude organic heteromonocyclic parent;
monocyclic heteroarene		carcinogenic agent;
hepatotoxic agent;
Maillard reaction product
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.2510glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
puupehenone
[no description available]		3.3110
24-methylenecholesterol
24-methylenecholesterol: RN given refers to (3beta)-isomer; structure. 24-methylenecholesterol : A 3beta-sterol having the structure of cholesterol with a methylene group at C-24.		3.31103beta-hydroxy-Delta(5)-steroid;
3beta-sterol		mouse metabolite
brevianamide f
brevianamide F: isolated from the endophyte from Aspergillus fumigatus associated with Melia azedarach L that could be used to develop a natural eco-friendly herbicide.structure in first source. brevianamide F : A pyrrolopyrazine that is hexahydropyrrolo[1,2-a]pyrazine-1,4-dione bearing an indol-3-ylmethyl substituent at position 3 (the 3S,8aS-diastereomer, obtained by formal cyclocondensation of L-tryptophan and L-proline).		3.6620dipeptide;
indoles;
pyrrolopyrazine		metabolite
epinephrine
ircinal A: from an Indonesian Acanthostrongylophora sponge with activity against infectious, tropical parasitic, and Alzheimer's diseases; structure in first source		3.3110
caulerpin
caulerpin: pigment from green algae, Caulerpa lamourouxii; structure		3.3110
sclerotiorin
sclerotiorin: isolated from monoverticillate Penicillia; RN given for (R-(R*,S*-(E,E)))-isomer; structure in first source		3.3110azaphilone
pseudopteroxazole
pseudopteroxazole: structure in first source		3.3110tetralinsmetabolite
manzamine a
manzamine A: RN given refers to (1R-(1R*,9Z,13S*,13aR*,20aR*,21aR*)-isomer; RN for cpd without isomeric designation not avail 12/92. manzamine A : An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).		3.3110alkaloid;
beta-carbolines;
isoquinolines		animal metabolite;
anti-HSV-1 agent;
antimalarial;
antineoplastic agent;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
marine metabolite
halicyclamine a
halicyclamine A: structure in first source		3.3110
1,4-dihydroxy-2-methoxy-7-methylanthraquinone
[no description available]		3.3110
proximicin a
proximicin A: antineoplastic agent isolated from Verrucosispora; structure in first source		3.3160
proximicin c
proximicin C: antineoplastic agent isolated from Verrucosispora; structure in first source		3.4570
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		2.0710
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		2.1310monohydroxybenzoateplant metabolite
sch 419560
Sch 419560: isolated from Pseudomonas fluorescens; structure in first source		3.3110
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		3.3110cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
4-deoxybostrycin
4-deoxybostrycin: crystalline red pigment from culture filtrate of Alternaria eichhorniae with antibacterial & phytotoxic activity; structure given in first source		3.3110
ConditionIndicatedRelationship StrengthStudiesTrials
Bacterial Disease
[description not available]		02.0710
Benign Neoplasms
[description not available]		02.0710
Bacterial Infections
Infections by bacteria, general or unspecified.		02.0710
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0710
Koch's Disease
[description not available]		03.1210
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		03.1210