Bacteremia, Hemorrhagic

Any of several bacterial diseases, usually caused by PASTEURELLA MULTOCIDA, marked by the presence of hemorrhagic areas in the subcutaneous tissues, serous membranes, muscles, lymph glands, and throughout the internal organs. The diseases primarily affect animals and rarely humans.

Synonym
Hemorrhagic Bacteremia
Haemorrhagic Bacteremia
Haemorrhagic Septicaemia
Haemorrhagic Septicemia
Septicemia, Hemorrhagic
Hemorrhagic Septicemia
Hemorrhagic Septicaemia
Bacteremia, Hemorrhagic

Excerpt	Reference
"Hemorrhagic septicemia is a fatal disease of cattle and buffaloes caused by P."	( Abba, Y; Chung, EL; Haron, AW; Ibrahim, HH; Jesse, FF; Lila, MA; Marza, AD; Mazlan, M; Omar, AR; Saharee, AA; Zakaria, MZ; Zamri-Saad, M, 2017)
"Hemorrhagic septicemia is a highly infectious and contagious disease caused by Pasteurella multocida serogroup B:2 in tropical Asian and African countries."	( Pandit, RS; Singh, M; Tarfain, NU; Verma, R, 2017)
"Hemorrhagic septicemia is a fatal disease of cattle and buffalo all over the world including Pakistan and it causes heavy economic losses every year."	( Afroz, H; Farooq, MZ; Rasool, A; Sattar, S, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	10 (22.22)	23.3326
1990's	9 (20.00)	12.5806
2000's	9 (20.00)	18.1394
2010's	14 (31.11)	28.8240
2020's	3 (6.67)	9.53

Drug	Relationship Strength	Studies	Trials
busulfan	low	1	0
sulfamerazine	low	1	0
sulfamethazine	low	1	0
sulfamethoxazole	low	1	0
sulfapyridine	low	1	0
trimethoprim	low	1	0
chloramphenicol	low	1	0
sucrose	low	1	0
trehalose	low	1	0
thiazoles	low	1	0
azacitidine	low	1	0
streptomycin	low	2	0
aluminum sulfate	medium	2	1
levamisole	low	1	0
transferrin	low	2	0
amikacin	low	1	0
thiazolyl blue	low	1	0
enrofloxacin	low	1	0
glucuronic acid	low	1	0
interleukin-1beta (163-171)	low	1	0
clindamycin	low	1	0
squalene	low	1	0
aluminum	low	1	0
chitosan	low	1	0
oxytetracycline, anhydrous	low	1	0
bassianolide	low	1	0
hyaluronoglucosaminidase	low	4	0
lactoferrin	low	1	0
thromboplastin	low	1	0
chondroitin sulfates	low	1	0
exudates	low	1	0

Protein Targets (306)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
estrogen nuclear receptor alpha	10	0	0	10
peripheral myelin protein 22	3	0	0	3
histone acetyltransferase KAT2A isoform 1	3	0	0	3
lamin isoform A-delta10	4	0	0	4
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	5
Bile salt export pump	0	10	0	10
Canalicular multispecific organic anion transporter 1	0	4	0	4
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, Beta-lactamase	4	0	0	4
interleukin 8	5	0	0	5
glp-1 receptor, partial	1	0	0	1
pregnane X receptor	1	0	0	1
RAR-related orphan receptor gamma	5	0	0	5
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	2	0	0	2
NFKB1 protein, partial	2	0	0	2
PPM1D protein	1	0	0	1
TDP1 protein	4	0	0	4
GLI family zinc finger 3	4	0	0	4
Thrombopoietin	1	0	0	1
AR protein	6	0	0	6
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
progesterone receptor	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
glucocorticoid receptor [Homo sapiens]	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
retinoid X nuclear receptor alpha	4	0	0	4
estrogen-related nuclear receptor alpha	4	0	0	4
farnesoid X nuclear receptor	3	0	0	3
pregnane X nuclear receptor	7	0	0	7
polyprotein	2	0	0	2
67.9K protein	2	0	0	2
Parkin	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
arylsulfatase A	1	0	0	1
IDH1	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	8	0	0	8
aryl hydrocarbon receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
activating transcription factor 6	3	0	0	3
Bloom syndrome protein isoform 1	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
chromobox protein homolog 1	4	0	0	4
thyroid hormone receptor beta isoform 2	5	0	0	5
huntingtin isoform 2	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
geminin	9	0	0	9
muscarinic acetylcholine receptor M1	2	0	0	2
Interferon beta	4	0	0	4
Cellular tumor antigen p53	4	0	0	4
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Adenosine receptor A3	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Spike glycoprotein	3	0	0	3
Multidrug and toxin extrusion protein 1	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
15-lipoxygenase, partial	1	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
EWS/FLI fusion protein	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
lethal factor (plasmid)	3	0	0	3
Matrix metalloproteinase-9	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
G	3	0	0	3
cytochrome P450 2D6	3	0	0	3
heat shock protein beta-1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
streptokinase A precursor	0	0	2	2
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Cytochrome P450 3A4	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	3	0	0	3
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	3	0	0	3
Protein-arginine deiminase type-4	0	6	0	6
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
SMAD family member 2	1	0	0	1
USP1 protein, partial	2	0	0	2
SMAD family member 3	1	0	0	1
Microtubule-associated protein tau	4	0	0	4
nonstructural protein 1	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
TAR DNA-binding protein 43	1	0	0	1
dopamine D1 receptor	2	0	0	2
thioredoxin reductase	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
flap endonuclease 1	2	0	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
WRN	1	0	0	1
phosphopantetheinyl transferase	2	0	0	2
GLS protein	1	0	0	1
Valosin-containing protein	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
Histone H2A.x	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
thyroid hormone receptor beta isoform a	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA polymerase kappa isoform 1	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Squalene monooxygenase	0	0	0	1
Bile salt export pump	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Carbonic anhydrase 2	0	3	1	4
Carbonic anhydrase 9	0	1	1	2
cytochrome P450 2C9 precursor	1	0	0	1
Histamine H2 receptor	1	0	0	1
acetylcholinesterase	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
GABA theta subunit	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Dihydrofolate reductase	0	3	0	4
Endothelin-1 receptor	0	1	0	1
Protease	0	1	1	2
Chain A, Ferritin light chain	1	0	0	1
Chain A, Cruzipain	1	0	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 6	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Cystine/glutamate transporter	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with trehalose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with cellobiose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with maltose	0	1	0	1
Trehalose-phosphatase	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
endonuclease IV	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Cytochrome P450 2C9	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(8)

Research Excerpts

Overview

Research

Studies (45)

Protein Targets (306)

Bacteremia, Hemorrhagic

Synonyms(8)

Research Excerpts

Overview

Research

Studies (45)

Drugs Studied (43)

Protein Targets (306)