Compounds > maculine
Page last updated: 2024-11-06

maculine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

maculine: isolated from Esenbeckia grandiflora; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Esenbeckiagenus[no description available]RutaceaeA plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH]

Cross-References

ID SourceID
PubMed CID68232
CHEMBL ID503675
CHEBI ID6629
MeSH IDM0492396

Synonyms (29)

Synonym
9-methoxy[1,3]dioxolo[4,5-g]furo[2,3-b]quinoline
9-methoxy-1,3-dioxolo(4,5-g)furo(2,3-b)quinoline
brn 0255599
ccris 3577
makulin
nsc-94658
maculin
1,5-g]furo[2,3-b]quinoline, 9-methoxy-
nsc94658
9-methoxy-2h-1,3-dioxolano[4,5-g]furano[2,3-b]quinoline
maculine
1,3-dioxolo(4,5-g)furo(2,3-b)quinoline, 9-methoxy-
524-89-0
chebi:6629 ,
CHEMBL503675
67w5vpj6ax ,
unii-67w5vpj6ax
nsc 94658
4-27-00-06795 (beilstein handbook reference)
1,3-dioxolo[4,5-g]furo[2,3-b]quinoline, 9-methoxy-
9-methoxy[1,3]dioxolo[4,5-g]furo[2,3-b]quinoline #
VPNYHHBCMOYPCJ-UHFFFAOYSA-N
DTXSID90200416
AKOS030617079
Q27107282
8-methoxy-4,12,14-trioxa-2-azatetracyclo[7.7.0.03,7.011,15]hexadeca-1(16),2,5,7,9,11(15)-hexaene
9-methoxy-[1,3]dioxolo[4,5-g]furo[2,3-b]quinoline
XM161788
9-methoxy-1,3-dioxolo[4,5-g]furo[2,3-b]quinoline
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
oxacycleAny organic heterocyclic compound containing at least one ring oxygen atom.
organonitrogen heterocyclic compoundAny organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
organic heterotricyclic compoundAn organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID436156Cytotoxicity against human A549 cells by SRB assay2008Journal of natural products, Nov, Volume: 71, Issue:11
Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens.
AID1755695Inhibition of GST-tagged recombinant RANKL/M-CSF-induced osteoclastogenesis in C57BL/6 mouse bone marrow derived macrophages assessed as TRAcP enzymatic activity incubated for 5 days with subsequent replenishment of media for 2 days and measured by leucoc2021European journal of medicinal chemistry, Jan-15, Volume: 210Deep learning enables discovery of highly potent anti-osteoporosis natural products.
AID355720Cytotoxicity against human A2780 cells2003Journal of natural products, Apr, Volume: 66, Issue:4
New cytotoxic alkaloids from the wood of Vepris punctata from the Madagascar rainforest.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's2 (28.57)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 101.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index101.86 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.49 (4.65)
Search Engine Demand Index178.91 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (101.86)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ibuprofen
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine		2.0410monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
skimmianine
skimmianine: furanoquinoline alkaloid from Teclea (RUTACEAE)		2.7530alkaloid antibiotic;
organic heterotricyclic compound;
organonitrogen heterocyclic compound;
oxacycle
kokusaginine
kokusaginine: antimalarial alkaloid from Teclea afzelii; structure in first source		3.1750organic heterotricyclic compound;
organonitrogen heterocyclic compound;
oxacycle
flindersiamine
flindersiamine: from Helietta parvifolia; structure		2.7530organic heterotricyclic compound;
organonitrogen heterocyclic compound;
oxacycle
limonin
[no description available]		2.0410epoxide;
furans;
hexacyclic triterpenoid;
lactone;
limonoid;
organic heterohexacyclic compound		inhibitor;
metabolite;
volatile oil component
dactinomycin
Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)		2.0110actinomycinmutagen
glycosides
[no description available]		2.2110
heliparvifoline
heliparvifoline: from Helietta parvifolia; structure		2.0410organic heterotricyclic compound;
organonitrogen heterocyclic compound;
oxacycle
andrographolide
[no description available]		2.3110carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol		anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite
tilianin
tilianin: from several medicinal plants including Agastache rugosa and Dracocephalum moldavia		2.2110
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.0210benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Ovary
[description not available]		02.0110
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.0110
Age-Related Osteoporosis
[description not available]		02.3110
Osteoporosis
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.		02.3110